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2. Trimethylamine-N-oxide and cerebral stroke risk: A review

Author

Dolkar, Phurbu, Deyang, Tenzin, Anand, Nikhilesh, Rathipriya, Annan Gopinath, Hediyal, Tousif Ahmed, Chandrasekaran, Vichitra, Krishnamoorthy, Naveen Kumar, Gorantla, Vasavi Rakesh, Bishir, Muhammed, Rashan, Luay, Chang, Sulie L., Sakharkar, Meena Kishore, Yang, Jian, and Chidambaram, Saravana Babu

Published
2024
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6. Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update

Author

Hediyal, Tousif Ahmed, primary, Vichitra, C., additional, Anand, Nikhilesh, additional, Bhaskaran, Mahendran, additional, Essa, Saeefh M., additional, Kumar, Pravir, additional, Qoronfleh, M. Walid, additional, Akbar, Mohammed, additional, Kaul-Ghanekar, Ruchika, additional, Mahalakshmi, Arehally M., additional, Yang, Jian, additional, Song, Byoung-Joon, additional, Monaghan, Tanya M., additional, Sakharkar, Meena Kishore, additional, and Chidambaram, Saravana Babu, additional

Published
2024
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7. Role of the Gut Bacteria-Derived Metabolite Phenylacetylglutamine in Health and Diseases

Author

Krishnamoorthy, Naveen Kumar, primary, Kalyan, Manjunath, additional, Hediyal, Tousif Ahmed, additional, Anand, Nikhilesh, additional, Kendaganna, Pavan Heggadadevanakote, additional, Pendyala, Gurudutt, additional, Yelamanchili, Sowmya V., additional, Yang, Jian, additional, Chidambaram, Saravana Babu, additional, Sakharkar, Meena Kishore, additional, and Mahalakshmi, Arehally M., additional

Published
2024
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9. Polyphenols, Autophagy and Neurodegenerative Diseases: A Review

Author

Chandrasekaran, Vichitra, primary, Hediyal, Tousif Ahmed, additional, Anand, Nikhilesh, additional, Kendaganna, Pavan Heggadadevanakote, additional, Gorantla, Vasavi Rakesh, additional, Mahalakshmi, Arehally M., additional, Ghanekar, Ruchika Kaul, additional, Yang, Jian, additional, Sakharkar, Meena Kishore, additional, and Chidambaram, Saravana Babu, additional

Published
2023
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13. The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders.

Author

Anand, Nikhilesh, Gorantla, Vasavi Rakesh, and Chidambaram, Saravana Babu

Subjects
*CENTRAL nervous system physiology, *NEUROBEHAVIORAL disorders, *BLOOD-brain barrier, *PATHOLOGICAL physiology, *DYSBIOSIS, *FECAL microbiota transplantation
Abstract

Mounting evidence shows that the complex gut microbial ecosystem in the human gastrointestinal (GI) tract regulates the physiology of the central nervous system (CNS) via microbiota and the gut–brain (MGB) axis. The GI microbial ecosystem communicates with the brain through the neuroendocrine, immune, and autonomic nervous systems. Recent studies have bolstered the involvement of dysfunctional MGB axis signaling in the pathophysiology of several neurodegenerative, neurodevelopmental, and neuropsychiatric disorders (NPDs). Several investigations on the dynamic microbial system and genetic–environmental interactions with the gut microbiota (GM) have shown that changes in the composition, diversity and/or functions of gut microbes (termed "gut dysbiosis" (GD)) affect neuropsychiatric health by inducing alterations in the signaling pathways of the MGB axis. Interestingly, both preclinical and clinical evidence shows a positive correlation between GD and the pathogenesis and progression of NPDs. Long-term GD leads to overstimulation of hypothalamic–pituitary–adrenal (HPA) axis and the neuroimmune system, along with altered neurotransmitter levels, resulting in dysfunctional signal transduction, inflammation, increased oxidative stress (OS), mitochondrial dysfunction, and neuronal death. Further studies on the MGB axis have highlighted the significance of GM in the development of brain regions specific to stress-related behaviors, including depression and anxiety, and the immune system in the early life. GD-mediated deregulation of the MGB axis imbalances host homeostasis significantly by disrupting the integrity of the intestinal and blood–brain barrier (BBB), mucus secretion, and gut immune and brain immune functions. This review collates evidence on the potential interaction between GD and NPDs from preclinical and clinical data. Additionally, we summarize the use of non-therapeutic modulators such as pro-, pre-, syn- and post-biotics, and specific diets or fecal microbiota transplantation (FMT), which are promising targets for the management of NPDs. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Antimicrobial agents' utilization and cost pattern in an Intensive Care Unit of a Teaching Hospital in South India

Author

Anand, Nikhilesh, Nayak, I. Nagendra, Advaitha, M., Thaikattil, Noble, Kantanavar, Kiran, and Anand, Sanjit

Subjects
Health care costs -- Analysis, Antibiotics -- Dosage and administration -- Research, Health
Abstract

Byline: Nikhilesh. Anand, I. Nagendra Nayak, M. Advaitha, Noble. Thaikattil, Kiran. Kantanavar, Sanjit. Anand Background and Aims: High utilization and inappropriate usage of antimicrobial agents (AMAs) in an Intensive Care [...]

Published
2016

15. Oncoyeasti: a web-based application to translate data obtained from Saccharomyces cerevisiae high-throughput drug screens into cancer therapeutics

Author

Gupta, Ruby, primary, Cayenne, Samir, additional, Dyavaiah, Madhu, additional, Srinivas, Pragnya, additional, Otohinoyi, David, additional, Talukdar, Debjyoti, additional, Halari, Moheem, additional, Halari, Chidambra, additional, Ramani, Ashok, additional, Yusuf, Joshua, additional, Chahal, Khushdeep, additional, Kaur, Rupinder, additional, Patel, Ankit, additional, Patel, Avaniben, additional, Rajput, Ravindrasingh, additional, Siddaiah, Harish, additional, Patil, Shilpadevi, additional, Patil, Ashish, additional, and Anand, Nikhilesh, additional

Published
2018
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