1. Specifics of self-organization and properties of highly dilute aqueous solutions of polyoxidonium
- Author
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L. I. Murtazina, S. Yu. Sergeeva, Irina S. Ryzhkina, Alla V. Chernova, A. B. Margulis, S. A. Ryzhkin, R. A. Safiullin, M. K. Kadirov, A. P. Timosheva, and A. I. Konovalov
- Subjects
Aqueous solution ,Conductometry ,010405 organic chemistry ,Chemistry ,Analytical chemistry ,Nanoparticle tracking analysis ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Ultraviolet visible spectroscopy ,Transmission electron microscopy ,Phase (matter) ,Nanometre ,Electrophoretic light scattering - Abstract
Using a combination of physicochemical methods (dynamic and electrophoretic light scattering (DLS and ELS, respectively), nanoparticle tracking analysis, atomic force and transmission electron microscopy (AFM and TEM, respectively), UV spectroscopy, conductometry, pH-metry, dielcometry), it was found that dilute solutions of a multicomponent drug immunomodulator polyoxidonium (PO) are nanoheterogeneous disperse systems, with their disperse phase undergoing considerable restructurings when diluting the solution in the range of calculated concentrations from 1∙10–1 to 1∙10–16 mg mL–1, which is reflected in the non-monotonous concentration dependencies of specific electroconductivity, dielectric permittivity, and pH of the solutions. Using ELS, AFM, TEM, and UV spectroscopy methods, it was found that the disperse phase with a size of hundreds of nanometers which forms at concentrations of ≤1∙10–5 mg mL–1, contains organized water structures substantiating the negative values of ζ-potential, which vary non-monotonously from–5 to–16 mV. Radioprotective properties of dilute solutions of PO (1∙10–1 and 1∙10–9 mg mL–1) were demonstrated for the first time when exposing the test mutant bacterial strain Salmonella typhimurium TA 100 (Ames test) to X-ray radiation in a dose of 7.50 mGy used for medical diagnostics.
- Published
- 2016