1,034 results on '"Alex Adams"'
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2. A word with Alex Adams of the division of financial management
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Governors -- Forecasts and trends ,Financial management -- Forecasts and trends ,Company business management ,Company financing ,Market trend/market analysis ,Business ,News, opinion and commentary ,Business, regional - Abstract
Byline: Catie Clark The Idaho Business Review asked the State of Idaho how the economic position for the state may have been affected by the national election results. Alex Adams [...]
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- 2020
3. Patient and Public Involvement (PPI) and Responsible Research and Innovation (RRI) approaches in mental health projects involving young people: a scoping review protocol
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Josimar Antônio de Alcântara Mendes, Mathijs Lucassen, Alex Adams, Lucy Martin, Christine Aicardi, Rebecca Woodcock, Emma Nielsen, Ellen Townsend, and Marina Jirotka
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Mental health ,Patient and public involvement ,Responsible research and innovation ,Young people ,Youth participation ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Background Rather than being perceived as merely ‘part of the problem’, the perspectives and experiences of young people play a pivotal role in devising effective solutions for mental health challenges. Two distinct methodologies that aid in this endeavour are ‘patient and public involvement’ (PPI) and ‘responsible research and innovation’ (RRI). However, there is a tendency to conflate PPI and RRI practices, leading to ambiguity in their application. Moreover, the extent and nature of young people’s involvement in mental health-related projects (namely: research, intervention, product development) employing these methodologies, and the subsequent implications thereof, remain unclear. Consequently, the proposed scoping review aims to identify and analyse literature pertaining to PPI and RRI approaches in mental health projects that engage young people in collaboration. Methods The selected databases will be MEDLINE, PsycINFO, PsycArticles, Scopus, Web of Science, IBBS, CINAHL (EBSCO) and ASSIA. Comprehensive searches will span from the inception of each database. A pilot test will be conducted to assess the screening criteria and data extraction form, with two authors independently reviewing titles and abstracts. Full-text articles meeting the inclusion criteria will undergo narrative syntheses, with results presented in tabular format. Feedback on the findings from a youth perspective will be sought from young people within our broader research network, namely Sprouting Minds. The review will adhere to the guidelines outlined by the Joanna Briggs Institute (JBI) and follow the PRISMA-ScR procedures. Inclusion criteria will comprise English-language, primary research peer-reviewed articles focused on Patient and Public Involvement (PPI) or Responsible Research and Innovation (RRI), examining mental health-related research processes, interventions, and products developed in collaboration with young people. Studies employing quantitative, qualitative, and mixed-methods approaches will be considered, while non-journal publications will be excluded. Discussion The intended scoping review aims to map the literature concerning mental health-related projects that engage with young people through PPI or RRI approaches. The outcomes hold promise for enriching the participatory research domain, particularly in studies centred on young people and their mental well-being. Furthermore, by delineating potential overlaps and distinctions between PPI and RRI, the findings stand to aid mental health researchers and practitioners in making informed decisions about the most suitable approach for their projects when partnering with young individuals. Systematic review registration Open Science Framework (registration: DOI https://doi.org/10.17605/OSF.IO/N4EDB ).
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- 2024
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4. Real-world experience utilizing the nuvision 4D intracardiac echocardiography catheter for left atrial appendage closure
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Alex Adams, Riaz Mahmood, Nivedha Balaji, Priyadarshini Dixit, Shalabh Chandra, and David Weisman
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Atrial fibrillation ,Left atrial appendage occlusion ,Intracardiac echocardiography ,Stroke prevention ,Medicine ,Science - Abstract
Abstract Transesophageal echocardiography (TEE) has been the preferred imaging modality to help guide left atrial appendage closure. Newer technologies such as the Nuvision 4D Intracardiac echocardiography (ICE) catheter allow for real-time 3D imaging of cardiac anatomy. There are no direct comparison studies for procedural imaging between TEE and 4D ICE. To evaluate the performance and safety of left atrial appendage (LAA) closure procedures with the Watchman FLX and Amulet, guided by the Nuvision 4D ICE Catheter. This retrospective observational analysis was conducted on institutional LAAO National Cardiovascular Data Registry from January 2022 to March 2023. Patients had undergone LAA closure procedures with the Watchman FLX or Amulet device guided by TEE or a 4D ICE Catheter. The primary outcome evaluated was successful LAAO device placement. A total of 121 patients underwent LAAO device placement with 46 (38.0%) patients guided by 4D ICE during LAAO implantation. The 4D ICE group had a shorter procedural time compared with TEE guidance. Post procedural 45-day TEE post implant was also comparable for both groups with no patients in either group having incomplete closure of the left atrial appendage and peri-device leak > 5 mm. No device related complications (device related access, stroke, or pericardial effusion) occurred in either group at follow-up. There was no significant difference in device implant success or post procedural outcomes at 45 days in either the TEE or 4D ICE group. However, there was a noticeable improvement in procedural time with the 4D ICE catheter.
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- 2024
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5. Debuting author Alex Adams shares his reflections on moral and intellectual growth in a free society in new memoir
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Business, general - Abstract
EVESHAM TOWNSHIP, N.J. (PRWEB) May 17, 2022 Liberty and character play vital roles in the functioning of free societies, but are often overlooked. Alex Adams gives them the attention they [...]
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- 2022
6. A failing right heart in an eggshell: A case report of idiopathic constrictive pericarditis
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Nivedha Balaji, Sheriff N. Dodoo, Alex Adams, Priyadarshini Dixit, Giancarlo Acosta, and Jaime Burkle
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constrictive pericarditis ,fibrotic pericardium ,pericardial constriction ,pericardial disease ,Medicine ,Medicine (General) ,R5-920 - Abstract
key Clinical Message Constrictive Pericarditis is a rare fibrotic conversion of the pericardium that results in non‐specific clinical symptoms such as hepatomegaly, ascites, pleural effusions, and lower extremity edema. A multi‐modal diagnostic approach with cardiac imaging tools, cardiac hemodynamic measurements, and tissue biopsy can be used to diagnose Constrictive Pericarditis. Abstract Constrictive Pericarditis is a rare complication resulting in the fibrotic conversion of the pericardium secondary to idiopathic, infective, post‐surgical, or post‐radiation etiologies. The rigid and restrictive nature of the pericardium can result in non‐specific symptoms of volume overload that can mimic liver cirrhosis or congestive heart failure. We present the case of a 73‐year‐old female with constrictive pericarditis who presented with vague symptoms of abdominal pain, abdominal bloating, and bilateral lower extremity edema. This case report highlights the clinical manifestation, invasive, and non‐invasive diagnostic work‐up, and management of constrictive pericarditis.
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- 2024
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7. Developing a core outcome set for the health outcomes for children and adults with congenital oesophageal atresia and/or tracheo-oesophageal fistula: OCELOT task group study protocol
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Nigel J Hall, Anna-may Long, Nick Lansdale, Sebastian King, Lucy Bray, Tom Kovesi, Alex Adams, Jonathan Ducey, Paul Cullis, Shireen A Nah, Lin Yin Ong, Victoria Gray, Paul D Losty, Usha Krishnan, Corne De Vos, Warwick J Teague, Rebecca Thursfield, Sarah Gorst, Nadine Teunissen, Julia Faulkner, Lucia Gutierrez Gammino, Graham Slater, Laura Baird, Julia Brendel, Adam Donne, Eniola Folaranmi, Laura Hopwood, Dan Benscoter, Mike Rutter, and Aaron M Zorn
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Pediatrics ,RJ1-570 - Abstract
Introduction Heterogeneity in reported outcomes of infants with oesophageal atresia (OA) with or without tracheo-oesophageal fistula (TOF) prevents effective data pooling. Core outcome sets (COS) have been developed for many conditions to standardise outcome reporting, facilitate meta-analysis and improve the relevance of research for patients and families. Our aim is to develop an internationally-agreed, comprehensive COS for OA-TOF, relevant from birth through to transition and adulthood.Methods and analysis A long list of outcomes will be generated using (1) a systematic review of existing studies on OA-TOF and (2) qualitative research with children (patients), adults (patients) and families involving focus groups, semistructured interviews and self-reported outcome activity packs. A two-phase Delphi survey will then be completed by four key stakeholder groups: (1) patients (paediatric and adult); (2) families; (3) healthcare professionals; and (4) researchers. Phase I will include stakeholders individually rating the importance and relevance of each long-listed outcome using a 9-point Likert scale, with the option to suggest additional outcomes not already included. During phase II, stakeholders will review summarised results from phase I relative to their own initial score and then will be asked to rescore the outcome based on this information. Responses from phase II will be summarised using descriptive statistics and a predefined definition of consensus for inclusion or exclusion of outcomes. Following the Delphi process, stakeholder experts will be invited to review data at a consensus meeting and agree on a COS for OA-TOF.Ethics and dissemination Ethical approval was sought through the Health Research Authority via the Integrated Research Application System, registration no. 297026. However, approval was deemed not to be required, so study sponsorship and oversight were provided by Alder Hey Children’s NHS Foundation Trust. The study has been prospectively registered with the COMET Initiative. The study will be published in an open access forum.
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- 2024
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8. Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease
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Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou, Alex Adams, Alexandra Noble, Nicholas T. Ventham, Judith Wellens, Gwo-Tzer Ho, Malcolm G. Dunlop, Jan Krzysztof Nowak, Yuan Ding, Zhanju Liu, Jack Satsangi, Evropi Theodoratou, and Xue Li
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Science - Abstract
Abstract This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking behaviors, smoking-related DNA methylation and the risks of Crohn’s disease (CD) and ulcerative colitis (UC). We then perform both genome-wide methylation analysis and co-localization analysis to validate the observed associations. Compared to never smoking, current and previous smoking habits are associated with increased CD (P = 7.09 × 10−10) and UC (P
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- 2024
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9. Author Correction: Real-world experience utilizing the nuvision 4D intracardiac echocardiography catheter for left atrial appendage closure
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Alex Adams, Riaz Mahmood, Nivedha Balaji, Priyadarshini Dixit, Shalabh Chandra, and David Weisman
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Medicine ,Science - Published
- 2024
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10. Alex Adams, Political Torture in Popular Culture: The Role of Representations in the Post-9/11 Torture Debate (London: Routledge, 2016, £110.00). Pp. 218. isbn978 1 1381 8531 9.
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KEEBLE, ARIN, primary
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- 2019
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11. Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel DiseaseSummary
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Vincent Joustra, Andrew Y.F. Li Yim, Ishtu Hageman, Evgeni Levin, Alex Adams, Jack Satsangi, Wouter J. de Jonge, Peter Henneman, and Geert D’Haens
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Biomarkers ,Epigenetics ,Personalized Medicine ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: There is great current interest in the potential application of DNA methylation alterations in peripheral blood leukocytes (PBLs) as biomarkers of susceptibility, progression, and treatment response in inflammatory bowel disease (IBD). However, the intra-individual stability of PBL methylation in IBD has not been characterized. Here, we studied the long-term stability of all probes located on the Illumina HumanMethylation EPIC BeadChip array. Methods: We followed a cohort of 46 adult patients with IBD (36 Crohn’s disease [CD], 10 ulcerative colitis [UC]; median age, 44 years; interquartile range [IQR] 27–56 years; 50% female) that received standard care follow-up at the Amsterdam University Medical Centers. Paired PBL samples were collected at 2 time points with a median of 7 years (range, 2–9 years) in between. Differential methylation and intra-class correlation (ICC) analyses were used to identify time-associated differences and temporally stable CpGs, respectively. Results: Around 60% of all EPIC array loci presented poor intra-individual stability (ICC
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- 2023
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12. Expunging Board of Pharmacy Disciplinary Actions
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Alex Adams and Timothy P. Frost
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Pharmacy and materia medica ,RS1-441 - Abstract
Boards of pharmacy have the authority to discipline licensees whose actions fall short of practice standards. Disciplinary action may include license suspension, revocation, practice restrictions, fines and reprimands. Once discipline is levied against a board of pharmacy licensee, it is usually part of the licensee’s permanent record. At least four states have created a pathway for individuals to seek expungement of previous disciplinary actions levied by a board of pharmacy. These states have variations on what violations may be expunged and when. Given the evolving approach to the regulation of pharmacists, more states may want to consider expungement pathways in the years ahead.
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- 2023
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13. Predictors and outcomes of healthcare-associated infections in COVID-19 patients
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Gagan Kumar, Alex Adams, Martin Hererra, Erine Raybon Rojas, Vartika Singh, Ankit Sakhuja, Mark Meersman, Drew Dalton, Shravan Kethireddy, Rahul Nanchal, and Achuta Kumar Guddati
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COVID-19 ,Secondary infections ,Tocilizumab ,Hydroxychloroquine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction: Healthcare-associated infections (HAI) after viral illnesses are important sources of morbidity and mortality. This has not been extensively studied in hospitalized COVID-19 patients. Methods: This study included all COVID-19-positive adult patients (≥18 years) hospitalized between 01 March and 05 August 2020 at the current institution. The Centers for Disease Control and Prevention definition of HAI in the acute care setting was used. The outcomes that were studied were rates and types of infections and in-hospital mortality. Several multivariable logistic regression models were constructed to examine characteristics associated with development of HAI. Results: Fifty-nine (3.7%) of 1565 patients developed 140 separate HAIs from 73 different organisms: 23 were Gram-positive, 39 were Gram-negative and 11 were fungal. Patients who developed HAI did not have higher odds of death (OR 0.85, 95% CI 0.40–1.81, p = 0.69). HAIs were associated with the use of tocilizumab (OR 5.04, 95% CI 2.4–10.6, p
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- 2021
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14. 206 Perceptions of the COIVD-19 Pandemic on Social, Mental, and Physical Health of Native American and Latino Communities
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Teresa Warne, Charlie Gregor, Linda K Ko, Paul K Drain, Georgina Perez, Selena Ahmed, Virgil Dupuis, Lorenzo Garza, and Alex Adams
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Medicine - Abstract
OBJECTIVES/GOALS: The COVID-19 pandemic impacted health systems and exposed disparities in access to health care among underserved populations. We examined how the pandemic shaped social, mental, and physical health among Native American and Latino communities in rural and underserved areas. METHODS/STUDY POPULATION: Using Theory of Planned Behavior, Social Cognitive Theory, and Social Contextual Factor frameworks, we developed interview guides to examine perceptions of the COVID-19 pandemic on social, mental, and physical health among community members. Stakeholders of the Confederated Salish and Kootenai Tribes of the Flathead Reservation in Montana and the Hispanic/Latinx population in Yakima Valley in Washington were selected through purposeful community-engagement. A total of six focus group discussions and 30 key informant interviews were administered in both communities. A codebook was developed and deductive coding was applied to informant responses, followed by an inductive, constant comparison approach. The codebook was further refined and inter-rater agreement was completed by three analysts. RESULTS/ANTICIPATED RESULTS: Four themes were highlighted as areas impacted by the COVID-19 pandemic (mental and physical health, family dynamics, and social disruptions) with few differences among geographic areas or between focus group (n=39) and key informant (n=28) participants. Perceived impacts on mental health included increased stress, anxiety, and depression, while pandemic-related lifestyle or family changes impacted physical health. Participants reported changes to family routines and dynamics due to staying home, social distancing, and more frequent interactions inside or limited interactions outside the household respectively. Social distruptions reported included impacts on finances, employment, and household staples, though participants highlighted how many community members stepped up to help those in need. DISCUSSION/SIGNIFICANCE: The COVID-19 pandemic had similar impacts on two geographically distinct underserved communities in Montana and Washington. Understanding the community’s experience with the COVID-19 pandemic is critical to identify strategies to support families, community needs, and mental and physical health in underserved communities.
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- 2023
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15. 221 Factors Influencing COVID-19 Testing among American Indians and Latinos in Two Rural Agricultural Communities: A Qualitative Study
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Dillon van Rensburg, Georgina Perez, Alex Adams, Teresa Warne, Thomas Quigley, Lorenzo Garza, Virgil Dupuis, Paul K Drain, and Linda K Ko
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Medicine - Abstract
OBJECTIVES/GOALS: Despite efforts to improve COVID-19 health outcomes through testing and vaccination, SARS-CoV-2 has exacerbated health disparities in underserved populations. Through this study we examined socio-contextual factors impacting decisions to test for COVID-19 among Native Americans in the Flathead Reservation and Hispanics in the Yakima Valley. METHODS/STUDY POPULATION: A series of 28 key informant interviews and 6 focus groups (N=39 focus group participants) were completed with community and tribal leaders using an interview guide informed by the Theory of Planned Behavior, Social Cognitive Theory, and the Social Contextual Factor Frameworks. The interview guide was designed to examine the socio-contextual factors impacting decisions to test for COVID-19 among Native Americans and Hispanics in the Northwest. A codebook was developed to apply deductive coding to informant responses, followed by an inductive, constant comparison approach. Three analysts met to refine the codebook and conduct inter-rater agreement. RESULTS/ANTICIPATED RESULTS: Five themes (social, cultural, health, religious and political factors) were identified that impacted testing for COVID-19. For social factors, participants discussed the influence of families and friends and unfair employment practices influencing decisions to test. Cultural factors included deep rooted distrust for the government and historical trauma. Health factors participants reported included the importance of testing to save lives, distrust for medical system, and health communications around COVID-19 affecting decisions to test. There was some interaction between religious and political factors. While participants mentioned beliefs in putting things in God’s hands, some decisions to test seemed to be affected by their political views. DISCUSSION/SIGNIFICANCE: Several socio-cultural factors influence decisions to test for COVID-19. Understanding the community’s perception of COVID-19 testing is critical for successful implementation of preventive strategies.
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- 2023
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16. 1988-1989 DePauw University Football: Alex Adams
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#58, OL, Sophomore, Deerfield, Illinois (Deerfield High School)
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- 1988
17. 1987-1988 DePauw University Football Player: Alex Adams
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#65, OG-C, Freshman, Deerfield, Illinois (Deerfield High School)
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- 1987
18. Does Increased State Pharmacy Regulatory Burden Lead to Better Public Safety Outcomes?
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Alex Adams and Jennifer Adams
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Pharmacy and materia medica ,RS1-441 - Abstract
Pharmacy has traditionally been a highly regulated profession. In a recent study, the state with the largest pharmacy regulatory word count had 6.7 times as many words as the state with the lowest word count. Given the wide variation in state pharmacy regulations, this paper seeks to spark discussion on how we can assess public safety outcomes in states based on the overall volume of pharmacy regulation with a focus on: 1) fitness to practice; 2) controlled substance outcomes; and 3) compounding safety. In examining these categories, existing data sources are limited and suboptimal, though formal disciplinary actions against pharmacy licensees are very infrequent. Thus, it seems preferable for states to have a regulatory framework that allows boards of pharmacy to deal with the rare public safety issues that occur, while not holding back the vast majority of pharmacists from practicing to the top of their education and training.
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- 2021
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19. 'Pharmacy to Dose': An Approach to Enhancing Team-Based Care
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Alex Adams
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Pharmacy and materia medica ,RS1-441 - Published
- 2021
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20. Pharmacy-Based Assessment and Management of Herpes Labialis (Cold Sores) with Antiviral Therapy
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Alex Adams and Michael Klepser
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Pharmacy, Scope of Practice, Permissionless Innovation, Prescriptive ,Pharmacy and materia medica ,RS1-441 - Abstract
Herpes labialis, commonly known as cold sores, is an infection of the mouth and surrounding area. Antiviral therapy can be used to block viral replication, which shortens the duration of symptoms, facilitates resolution of lesions, and lessens the risk of spreading the virus. Increasing access to antivirals targeted against herpes labialis by allowing assessment and prescribing by a pharmacist may decrease time to treatment for HSV-1, and improve patient satisfaction. Experience from Canada, Australia, New Zealand and the United States demonstrate that pharmacist management of cold sores has a safe track record and may be considered by other jurisdictions. Commentary
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- 2020
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21. Eliminating the Board of Pharmacy’s Role in Designating a Pharmacist-in-Charge
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Alex Adams
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Pharmacy and materia medica ,RS1-441 - Abstract
Nearly all states require that each licensed pharmacy designate a pharmacist-in-charge (PIC). By law, the PIC typically has responsibility for all professional practice laws and facility standards laws and can be held accountable for such. However, the extent to which the PIC has actual authority over many facility standards varies by organization. This can seemingly put a target on the back of the PIC for decisions they wield little authority over. Idaho recently removed the legal references to the PIC, signaling that facilities are responsible for facility standards and insulating pharmacists from discipline for matters that are outside their control. Letter
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- 2020
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22. Blame the War, Not the Troops: Good Kill
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Alex Adams
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History ,Anthropology ,Political Science and International Relations - Published
- 2022
23. Early management of acute severe UC in the biologics era: development and international validation of a prognostic clinical index to predict steroid response
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Alex Adams, Vipin Gupta, Waled Mohsen, Thomas P Chapman, Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Sudheer Kumar, Saurabh Kedia, Colleen GC McGregor, Tim Ambrose, Bruce D George, Rebecca Palmer, Oliver Brain, Alissa Walsh, Vineet Ahuja, Simon P L Travis, and Jack Satsangi
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Gastroenterology - Abstract
ObjectivesWe aimed to determine whether changes in acute severe colitis (ASC) management have translated to improved outcomes and to develop a simple model predicting steroid non-response on admission.DesignOutcomes of 131 adult ASC admissions (117 patients) in Oxford, UK between 2015 and 2019 were compared with data from 1992 to 1993. All patients received standard treatment with intravenous corticosteroids and endoscopic disease activity scoring (Ulcerative Colitis Endoscopic Index of Severity (UCEIS)). Steroid non-response was defined as receiving medical rescue therapy or surgery. A predictive model developed in the Oxford cohort was validated in Australia and India (Gold Coast University Hospital 2015–2020, n=110; All India Institute of Medical Sciences, New Delhi 2018–2020, n=62).ResultsIn the 2015–2019 Oxford cohort, 15% required colectomy during admission vs 29% in 1992–1993 (p=0.033), while 71 (54%) patients received medical rescue therapy (27% ciclosporin, 27% anti-tumour necrosis factor, compared with 27% ciclosporin in 1992–1993 (p=0.0015). Admission C reactive protein (CRP) (false discovery rate, p=0.00066), albumin (0.0066) and UCEIS scores (0.015) predicted steroid non-response. A four-point model was developed involving CRP of ≥100 mg/L (one point), albumin of ≤25 g/L (one point), and UCEIS score of ≥4 (1 point) or ≥7 (2 points). Patients scoring 0, 1, 2, 3 and 4 in the validation cohorts had steroid response rates of 100, 75.0%, 54.9%, 18.2% and 0%, respectively. Scoring of ≥3 was 84% (95% CI 0.70 to 0.98) predictive of steroid failure (OR 11.9, 95% CI 10.8 to 13.0). Colectomy rates in the validation cohorts were were 8%–11%.ConclusionsEmergency colectomy rates for ASC have halved in 25 years to 8%–15% worldwide. Patients who will not respond to corticosteroids are readily identified on admission and may be prioritised for early intensification of therapy.
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- 2023
24. Tricky papillary muscle rupture sequelae navigated by evidence-based therapies using ECMO and Impella
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Ugochukwu Egolum, Alex Adams, Martin Herrera, and Christine Sykalo
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This case illustrates an atypical mitral valve prolapse presentation with superimposed stress of acute respiratory distress syndrome (ARDS) as well as the importance of extracorporeal membrane oxygenation therapy (ECMO) as a bridge to definitive surgical intervention. Switching from venovenous (VV) to venoarterial (VA) ECMO allowed bypass of the pulmonary circulation and provided cardiac support to assist in systemic circulation in the setting of severe mitral regurgitation with mitral valve prolapse. However, VA ECMO increases afterload, thus an Impella was used to offload the left ventricle and provide forward flow. Relying on evidence-based medicine for each modality despite its complexity also optimized this patient’s chance for recovery. Thereby, we demonstrate a complex case of ARDS, mitral valve prolapse secondary to myocardial infarction, and subsequent multiple arrhythmic arrests, where successful VV and VA ECMO resuscitation afforded bridge therapy to definitive surgical management. Our patient showed promising results, and we would like to encourage this strategy to bridge patients requiring surgical intervention.
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- 2022
25. Pharmacists’ Patient Care Process: A State 'Scope of Practice' Perspective
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Alex Adams and Krystalyn Weaver
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Pharmacists’ Patient Care Process ,Scope of Practice ,Pharmacist Prescriptive Authority ,Collaborative Practice Agreement ,Pharmacy and materia medica ,RS1-441 - Abstract
Objective: Explore the intersection of the Pharmacists’ Patient Care Process (PPCP) and state laws in order to identify laws that may impede the delivery of optimal patient care. Summary: A review of the PPCP identified six areas in which state laws can limit full pharmacist engagement: 1) ordering and interpreting laboratory tests; 2) participating in a collaborative practice agreement; 3) independently prescribing certain medications; 4) independently adapting medications; 5) administering medications; and 6) effective delegation. A framework is put forth to organize how these scope of practice matters are interrelated. Conclusion: For pharmacists to fully engage in the PPCP, state laws must enable full participation. By unleashing pharmacists to fully engage in the process, patient care delivery and outcomes can be improved, and total health care costs can be reduced. Article Type: Commentary
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- 2019
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26. Reducing social media use improves appearance and weight esteem in youth with emotional distress
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Helen Thai, Christopher G. Davis, Wardah Mahboob, Sabrina Perry, Alex Adams, and Gary S. Goldfield
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Cultural Studies ,Communication ,Psychology (miscellaneous) ,Applied Psychology - Published
- 2023
27. Full Issue PDF, Volume 93, Supplement 1
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Alex Adams
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Nephrology ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,General Medicine - Published
- 2022
28. PO-03-138 REAL-WORLD EXPERIENCE UTILIZING THE NUVISION 4D INTRACARDIAC ECHOCARDIOGRAPHY CATHETER FOR LEFT TRIAL APPENDAGE CLOSURE
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Alex Adams, David Weisman, and Riaz Mahmood
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
29. Immune cell-specific smoking-related expression characteristics are revealed by re-analysis of transcriptomes from the CEDAR cohort
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Jan Nowak, Emilia Dybska, Alex Adams, and Jaroslaw Walkowiak
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Immunology ,Immunology and Allergy - Published
- 2022
30. SerumN-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel Disease
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Alex Adams, Rahul Kalla, and Jonas Halfvarson
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Gastroenterology ,General Medicine - Abstract
Biomarkers to guide clinical decision making at diagnosis of inflammatory bowel disease [IBD] are urgently needed. We investigated a composite serum N-glycomic biomarker to predict future disease course in a discovery cohort of 244 newly diagnosed IBD patients. In all, 47 individual glycan peaks were analysed using ultra-high performance liquid chromatography, identifying 105 glycoforms from which 24 derived glycan traits were calculated. Multivariable logistic regression was performed to determine associations of derived glycan traits with disease. Cox proportional hazard models were used to predict treatment escalation from first-line treatment to biologics or surgery (hazard ratio [HR] 25.9, p = 1.1 × 10-12; 95% confidence interval [CI], 8.52–78.78). Application to an independent replication cohort of 54 IBD patients yielded an HR of 5.1 [p = 1.1 × 10-5; 95% CI, 2.54–10.1]. These data demonstrate the prognostic capacity of serum N-glycan biomarkers and represent a step towards personalised medicine in IBD.
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- 2023
31. Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome
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Mauro D'Amato, Petr Ricanek, Alex Adams, Jonas Christoffer Lindstrøm, Nicholas A. Kennedy, Morten H. Vatn, Fernando Gomollón, Nicholas T. Ventham, Jonas Halfvarson, Christine Olbjørn, Rahul Kalla, Johan D. Söderholm, Daniel Bergemalm, Simen Vatn, Rebecca C Richmond, Jan Krzysztof Nowak, Caroline L Relton, Jørgen Jahnsen, Jack Satsangi, Marieke Pierik, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), and RS: NUTRIM - R2 - Liver and digestive health
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business.industry ,Gastroenterology ,General Medicine ,Gastroenterology and Hepatology ,medicine.disease ,Inflammatory bowel disease ,DNA methylation ,genetics ,inflammatory bowel diseases [IBD] ,prognosis ,methylation ,quantitative trait loci ,gene expression ,epigenetic clock ,Mendelian randomization ,Immune system ,Immunology ,Gastroenterologi ,Medicine ,Epigenetics ,business - Abstract
Background Epigenetic alterations may provide valuable insights into gene–environment interactions in the pathogenesis of inflammatory bowel disease [IBD]. Methods Genome-wide methylation was measured from peripheral blood using the Illumina 450k platform in a case-control study in an inception cohort (295 controls, 154 Crohn’s disease [CD], 161 ulcerative colitis [UC], 28 IBD unclassified [IBD-U)] with covariates of age, sex and cell counts, deconvoluted by the Houseman method. Genotyping was performed using Illumina HumanOmniExpressExome-8 BeadChips and gene expression using the Ion AmpliSeq Human Gene Expression Core Panel. Treatment escalation was characterized by the need for biological agents or surgery after initial disease remission. Results A total of 137 differentially methylated positions [DMPs] were identified in IBD, including VMP1/MIR21 [p = 9.11 × 10−15] and RPS6KA2 [6.43 × 10−13], with consistency seen across Scandinavia and the UK. Dysregulated loci demonstrate strong genetic influence, notably VMP1 [p = 1.53 × 10−15]. Age acceleration is seen in IBD [coefficient 0.94, p Conclusion These data demonstrate consistent epigenetic alterations at diagnosis in European patients with IBD, providing insights into the pathogenetic importance and translational potential of epigenetic mapping in complex disease.
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- 2023
32. Camp X-Ray and the Task of Critique: Torturability and the Politics of Ethical Recognition in Guantanamo
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Alex Adams
- Subjects
Visual Arts and Performing Arts - Published
- 2021
33. Long-term temporal stability of peripheral blood DNA methylation profiles in patients with inflammatory bowel disease
- Author
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Vincent Joustra, Andrew Y.F. Li Yim, Ishtu Hageman, Evgeni Levin, Alex Adams, Jack Satsangi, Wouter J. de Jonge, Peter Henneman, Geert D’Haens, Gastroenterology and Hepatology, Human Genetics, ACS - Atherosclerosis & ischemic syndromes, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, Experimental Vascular Medicine, ACS - Diabetes & metabolism, Tytgat Institute for Liver and Intestinal Research, and AII - Inflammatory diseases
- Subjects
Hepatology ,Gastroenterology ,Personalized Medicine ,Epigenetics ,Biomarkers - Abstract
Background & Aims: There is great current interest in the potential application of DNA methylation alterations in peripheral blood leukocytes (PBLs) as biomarkers of susceptibility, progression, and treatment response in inflammatory bowel disease (IBD). However, the intra-individual stability of PBL methylation in IBD has not been characterized. Here, we studied the long-term stability of all probes located on the Illumina HumanMethylation EPIC BeadChip array. Methods: We followed a cohort of 46 adult patients with IBD (36 Crohn's disease [CD], 10 ulcerative colitis [UC]; median age, 44 years; interquartile range [IQR] 27–56 years; 50% female) that received standard care follow-up at the Amsterdam University Medical Centers. Paired PBL samples were collected at 2 time points with a median of 7 years (range, 2–9 years) in between. Differential methylation and intra-class correlation (ICC) analyses were used to identify time-associated differences and temporally stable CpGs, respectively. Results: Around 60% of all EPIC array loci presented poor intra-individual stability (ICC
- Published
- 2022
34. Long-term temporal stability of peripheral blood DNA methylation alterations in patients with inflammatory bowel disease
- Author
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Vincent Joustra, Andrew Y.F. Li Yim, Ishtu Hageman, Evgeni Levin, Alex Adams, Jack Satsangi, Wouter J. de Jonge, Peter Henneman, and Geert D’Haens
- Abstract
IntroductionThere is great current interest in the potential application of DNA methylation alterations in peripheral blood leukocytes (PBL) as biomarkers of susceptibility, progression and treatment response in inflammatory bowel disease (IBD). However, the intra-individual stability of PBL methylation in IBD has not been characterised. Here, we studied the long-term stability of all probes located on the Illumina HumanMethylation EPIC BeadChip array.MethodsWe followed a cohort of 46 adult IBD patients (36 Crohn’s disease (CD), 10 ulcerative colitis (UC), median age 44 (IQR: 27-56), 50% female) that received standard care without any intervention at the Amsterdam UMC. Paired PBL samples were collected at two time points with a median 7 (range: 2-9) years in between. Differential methylation and intra-class correlation (ICC) analyses were used to identify time-associated differences and temporally stable CpGs, respectively.ResultsAround 60% of all EPIC array loci presented poor intra-individual stability (ICC HLA genes.ConclusionOur data provide insight into the long-term stability of the PBL DNA methylome within an IBD context, facilitating the selection of biologically relevant and robust IBD-associated epigenetic biomarkers with increased potential for independent validation. These data also have potential implications in understanding disease pathogenesis.
- Published
- 2022
35. PO-01-135 SAFETY AND TOLERABILITY OF INITIATING ORAL SOTALOL AS OUTPATIENT
- Author
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Riaz Mahmood, Aqsa Iqbal, Alex Adams, Christelle Yakana Moyine, Drew Dalton, Heidi Ehrenreich, Keith Adkins, Mandy Harris, Taylor Abu-Alrub, Kayla D. Rylee, Joon Ahn, Stephen P. Prater, David Weisman, and Shalabh Chandra
- Subjects
Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
36. Should Pharmacy Technicians Administer Immunizations?
- Author
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Dylan Atkinson, Alex Adams, and David Bright
- Subjects
immunizations ,pharmacy technicians ,pharmacy-based immunizations ,scope of practice ,Pharmacy and materia medica ,RS1-441 - Abstract
Purpose. To describe the potential role for pharmacy technicians in administering immunizations – limited for this discussion to specifically inserting the needle into the patient’s arm and pressing down on the plunger – at the discretion of a supervising pharmacist as a way to enhance patient care and workflow efficiency. Summary. Pharmacy technicians currently play an important role in facilitating pharmacy-based immunization programs. Technicians routinely perform non-clinical tasks related to pharmacy-based immunizations, though nearly all states prohibit technicians from administering vaccines. Several studies demonstrate that untrained laypersons can safely administer intranasal or intradermal vaccines, and laypersons routinely administer medications through intramuscular or subcutaneous routes (e.g., patients with diabetes or rheumatic conditions). It stands to reason that a trained pharmacy technician could perform comparably on these techniques that laypersons have mastered. One state has adopted rules to allow pharmacy technicians to administer immunizations if the technician has completed specific training on administration techniques and on basic life support. This task is performed at the discretion of the supervising pharmacist, and the pharmacist would still be responsible for clinical aspects of immunizing such as prescribing the right vaccine to the right patient. Additional considerations factoring into the decision as to whether or not to involve pharmacy technicians in immunization administration are also summarized. Conclusion. If safety can be reasonably assured through training and supervision, it may be appropriate to delegate vaccine administration to appropriately trained pharmacy technicians. Such delegation may enhance workflow efficiency, which may confer added value for patient care and potentially improve access to community pharmacy-based immunizations. Type: Commentary
- Published
- 2017
- Full Text
- View/download PDF
37. Pharmacy-Based Tuberculosis Skin Testing (TST): Approaches to Legal Authority
- Author
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Dylan Atkinson, Allison M. Dering-Anderson, and Alex Adams
- Subjects
Scope of Practice ,Tuberculosis Skin Testing ,Mantoux Test ,Permissionless Innovation ,Pharmacy and materia medica ,RS1-441 - Abstract
The Mantoux Tuberculin Skin Test (TST) is the standard method for detecting latent tuberculosis and has been provided by pharmacists since at least 2006. In the largest published study of pharmacy-based TST involving 578 patients, the most common reason for obtaining the test were employment or school requirements.Pharmacists have demonstrated high rates of follow-up for the reading of the test, reported to be 92.8% to 94.4%. The biggest barrier to pharmacy-based TST is that a prescription is required for the two tuberculosis (TB) purified protein derivative products available on the market in the United States. States have adopted three strategies to enable pharmacy-based TST prescribing: 1) collaborative practice agreements; 2) statewide protocols; and 3) independent prescribing. These three approaches are reviewed, with a focus on the New Mexico statewide protocol and the recent statutory authority in Idaho that grants pharmacists independent prescriptive authority for TST. States may consider pursuing more autonomous models of TST prescribing given the safety and track record of this service at pharmacies. Type: Commentary
- Published
- 2017
- Full Text
- View/download PDF
38. Decrease in uptake of SARS-CoV-2 vaccine in patients with inflammatory bowel disease on intravenous biological therapy
- Author
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Rania Selim, Judith Wellens, Stephanie Brann, Luke Marlow, Alex Adams, and Jack J Satsangi
- Subjects
Biological Therapy ,COVID-19 Vaccines ,Hepatology ,SARS-CoV-2 ,Chronic Disease ,Gastroenterology ,COVID-19 ,Humans ,Inflammatory Bowel Diseases - Published
- 2022
39. Pharmacist scope of practice expansion: The virtue of forbearance
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Alex Adams
- Subjects
Scope of practice ,Virtue ,Forbearance ,media_common.quotation_subject ,Pharmacist ,Pharmaceutical Science ,Pharmacology (medical) ,Engineering ethics ,Pharmacy ,Business ,media_common - Published
- 2021
40. Aleksandra Arkhipova On The History Of Russian Jewish Jokes, 1900–1990
- Author
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Alex Adams
- Subjects
History ,Sociology and Political Science ,Judaism ,Religious studies - Published
- 2021
41. Whole Blood Profiling of T-cell-Derived microRNA Allows the Development of Prognostic models in Inflammatory Bowel Disease
- Author
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Fernando Gomollón, Petr Ricanek, Gwo-Tzer Ho, Nicholas A. Kennedy, Simen Vatn, Nicholas T. Ventham, S McTaggart, Rahul Kalla, Daniel Bergemalm, Jan Krzysztof Nowak, C Clarke, B Lopez-Jimena, Alasdair Ivens, Jørgen Jahnsen, Morten H. Vatn, Jack Satsangi, Amy H. Buck, Johan D. Söderholm, Ruby White, Alex Adams, and Jonas Halfvarson
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,mRNA ,T-Lymphocytes ,Gastroenterology and Hepatology ,Polymerase Chain Reaction ,Inflammatory bowel disease ,T-cell ,inflammatory bowel disease ,Internal medicine ,Gastroenterologi ,medicine ,Humans ,Whole Body Imaging ,Prospective Studies ,ulcerative colitis ,Proportional Hazards Models ,Whole blood ,Crohn's disease ,epigenetics ,business.industry ,Proportional hazards model ,whole blood ,Gastroenterology ,Case-control study ,biomarkers ,MicroRNA ,General Medicine ,Middle Aged ,Inflammatory Bowel Diseases ,Prognosis ,medicine.disease ,proteins ,MicroRNAs ,crohn’s disease ,Case-Control Studies ,crohns disease ,prognosis ,Biomarker (medicine) ,Female ,business ,Biomarkers ,CD8 ,Progressive disease - Abstract
Background MicroRNAs [miRNAs] are cell-specific small non-coding RNAs that can regulate gene expression and have been implicated in inflammatory bowel disease [IBD] pathogenesis. Here we define the cell-specific miRNA profiles and investigate its biomarker potential in IBD. Methods In a two-stage prospective multi-centre case control study, next generation sequencing was performed on a discovery cohort of immunomagnetically separated leukocytes from 32 patients (nine Crohn’s disease [CD], 14 ulcerative colitis [UC], eight healthy controls) and differentially expressed signals were validated in whole blood in 294 patients [97 UC, 98 CD, 98 non-IBD, 1 IBDU] using quantitative PCR. Correlations were analysed with phenotype, including need for early treatment escalation as a marker of progressive disease using Cox proportional hazards. Results In stage 1, each leukocyte subset [CD4+ and CD8+ T-cells and CD14+ monocytes] was analysed in IBD and controls. Three specific miRNAs differentiated IBD from controls in CD4+ T-cells, including miR-1307-3p [p = 0.01], miR-3615 [p = 0.02] and miR-4792 [p = 0.01]. In the extension cohort, in stage 2, miR-1307-3p was able to predict disease progression in IBD (hazard ratio [HR] 1.98, interquartile range [IQR]: 1.20–3.27; logrank p = 1.80 × 10–3), in particular CD [HR 2.81; IQR: 1.11–3.53, p = 6.50 × 10–4]. Using blood-based multimarker miRNA models, the estimated chance of escalation in CD was 83% if two or more criteria were met and 90% for UC if three or more criteria are met. Interpretation We have identified and validated unique CD4+ T-cell miRNAs that are differentially regulated in IBD. These miRNAs may be able to predict treatment escalation and have the potential for clinical translation; further prospective evaluation is now indicated.
- Published
- 2020
42. Social workers’ perspectives on people parenting while patients in a secure hospital
- Author
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Ruth Bagshaw, Zoe Bezeczky, Natasha Kalebic, Pamela J. Taylor, Sarah Elizabeth Argent, and Alex Adams
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Psychiatry and Mental health ,Clinical Psychology ,Social work ,Nursing ,05 social sciences ,050501 criminology ,Child safeguarding ,Psychology ,Mental health ,Grounded theory ,0505 law - Abstract
Up to half of the approximately 10,000 people resident in a UK secure hospital are parents. There are well-established child safeguarding policies, but no model for social work support of parenting. Our study aimed to investigate social workers’ experience of secure hospital patients as parents and develop a testable model of good practice. Each social worker in one medium security hospital unit was invited to an individual semi-structured interview about his/her perspectives on patients parenting from the unit. Six social workers participated; all had experience there of patients with and without children. A core concern of ‘artificiality’ best encompassed the emergent themes covering the nature of the setting, poor mental health with sometimes delusional family life, difficult family dynamics, weakened parenting skills and patient-parent wish for communication inhibited by a sense of stigma. Resolution towards ‘naturalness’, with improved mental health, communication skills, family dynamics, and reducing confinement was partially achieved during the inpatient stay, much of the change actively facilitated by clinical interventions. While child safeguarding during a parent’s secure hospital stay is vital, longer-term psychosocial repair of relationships seems feasible. An actively restorative model envisaged by these social workers offers a testable progression towards responsible parenting.
- Published
- 2020
43. Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease: A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort
- Author
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Simen Svendsen Vatn, Jonas Christoffer Lindstrøm, Aina EF Moen, Stephan Brackmann, Tone M Tannæs, Christine Olbjørn, Daniel Bergemalm, Åsa V Keita, Fernando Gomollon, Trond Espen Detlie, Torben Lüders, Rahul Kalla, Alex Adams, Jack Satsangi, Jørgen Jahnsen, Morten H Vatn, Jonas Halfvarson, Petr Ricanek, and Hilde Nilsen
- Subjects
Näringslära ,Nutrition and Dietetics ,Clinical and Experimental Gastroenterology ,Crohns disease ,healthy controls ,mitochondria ,mucosal transcriptome ,non-inflamed ,prediction ,symptomatic controls ,ulcerative colitis ,Gastroenterology ,digestive system diseases - Abstract
Simen Svendsen Vatn,1,2,* Jonas Christoffer Lindstrøm,3,4,* Aina EF Moen,1,4,5 Stephan Brackmann,1,2 Tone M Tannæs,1,5 Christine Olbjørn,1,6 Daniel Bergemalm,7 Åsa V Keita,8 Fernando Gomollon,9 Trond Espen Detlie,1,2 Torben Lüders,5 Rahul Kalla,10 Alex Adams,10,11 Jack Satsangi,10,11 Jørgen Jahnsen,1,2 Morten H Vatn,1 Jonas Halfvarson,7 Petr Ricanek,2 Hilde Nilsen1,5 On behalf of IBD-CHARACTER consortium1Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 2Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; 3Health Services Research Unit (HØKH), Akershus University Hospital, Lørenskog, Norway; 4Department of Methods Development and Analytics, Division of Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway; 5Section for Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway; 6Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway; 7Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 8Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; 9Digestive Diseases Unit, IIS Aragón, Zaragoza, Spain; 10Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK; 11Translational Gastroenterology Unit, Medical Sciences/ Experimental medicine Division, University of Oxford, Oxford, UK*These authors contributed equally to this workCorrespondence: Simen Svendsen Vatn, Akershus University Hospital, Postbox 1000, Lørenskog, 1478, Norway, Tel +47 94277594, Email bikkjas@hotmail.comBackground: Studies of the mucosal transcriptomic landscape have given new insight into the pathogenesis of inflammatory bowel disease (IBD). Recently, the predictive biomarker potential of gene expression signatures has been explored. To further investigate the mucosal gene expression in IBD, we recruited a cohort of treatment naïve patients and compared them to both symptomatic and healthy controls.Methods: Altogether, 323 subjects were included: Crohn’s disease (N = 75), ulcerative colitis (N = 87) and IBD unclassified (N = 3). Additionally, there were two control groups: symptomatic controls (N = 131) and healthy controls (N = 27). Mucosal biopsies were collected during ileocolonoscopy and gene expression in inflamed and non-inflamed mucosa was explored. Gene expression profiling was performed using Agilent G3 Human Gene Expression 860K v3 One-Color microarray. We recorded information about treatment escalation to anti-TNF agents or surgery, and anti-TNF response, to explore predictive opportunities of the mucosal transcriptome.Results: Gene expression profiles in symptomatic controls in whom IBD had been excluded resembled that of IBD patients and diverged from that of healthy controls. In non-inflamed Crohn’s disease and ulcerative colitis, gene set enrichment analysis revealed dysregulation of pathways involved in basic cellular biological processes. Mitochondria-associated pathways were dysregulated both in non-inflamed and inflamed Crohn’s disease and ulcerative colitis (> 2.6 normalized enrichment scores
- Published
- 2022
44. Ultrasound Assessment of Diaphragmatic Motion in Subjects With ARDS During Transpulmonary Pressure-Guided PEEP Titration
- Author
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Matthew E. Prekker, Roy Cho, Alex Adams, Robert S. Shapiro, Scott Lunos, and Sum Ambur
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,ARDS ,Future studies ,Diaphragm ,Diaphragmatic breathing ,Critical Care and Intensive Care Medicine ,Positive-Pressure Respiration ,Motion ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,Aged ,Ultrasonography ,Respiratory Distress Syndrome ,business.industry ,Ultrasound ,General Medicine ,Middle Aged ,respiratory system ,medicine.disease ,respiratory tract diseases ,Diaphragm (structural system) ,030228 respiratory system ,Respiratory Mechanics ,Cardiology ,Female ,Diaphragmatic excursion ,business ,Transpulmonary pressure - Abstract
BACKGROUND: We aimed to investigate the effects of incremental PEEP titration in patients with ARDS on regional diaphragmatic motion with bedside ultrasound. METHODS: Dorsal diaphragmatic excursion (DDE) and ventral diaphragmatic excursion (VDE) were measured using anatomic M-mode ultrasonography of the right hemidiaphragm as PEEP was randomized to −6, −3, +3, and +6 cm H2O from baseline to achieve a positive transpulmonary pressure. Inter-operator variability of DDE was assessed in 10 separate subjects. RESULTS: A total of 14 subjects ventilated for ARDS were enrolled. Subjects had a mean age of 54 ± 12 y, mean PaO2/FIO2 = 137 ± 54 mm Hg, and mean sequential organ failure assessment (SOFA) score = 14 ± 1). Transpulmonary pressure, DDE, and DDE/VDE ratio increased with incremental PEEP titration (−1.15 cm H2O vs 3.63 cm H2O, P CONCLUSIONS: DDE was affected by incremental PEEP titration toward a positive transpulmonary pressure. The ultrasound assessment using anatomic M-mode allowed for specific measurement of regional diaphragmatic excursion. This pattern of motion in the dependent regions of the diaphragm during PEEP titration in subjects with ARDS achieving a positive transpulmonary pressure may reflect a potential target for future studies in the bedside assessment for lung recruitment. (Clinical Trials.gov registration NCT02463773.)
- Published
- 2019
45. OFR-10 Admission model for intensification of therapy in acute severe colitis (ADMIT-ASC)
- Author
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Pradeep Ramaswamy, Vineet Ahuja, Vipin Gupta, Thomas Chapman, Oxford Ibd Cohort investigators, Jack Satsangi, D Subhaharan, Waled Mohsen, Alex Adams, and Simon Travis
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,business ,Gastroenterology ,Severe colitis - Published
- 2021
46. OMO-1 Epigenetic alterations in IBD: defining geographical, genetic, and immune-inflammatory influences on the circulating methylome
- Author
-
Nicholas T. Ventham, Mauro D'Amato, Jørgen Jahnsen, Nicholas A. Kennedy, Daniel Bergemalm, Alex Adams, Simen Vatn, Rahul Kalla, Jonas Christoffer Lindstrøm, Rebecca C Richmond, Jan Krzysztof Nowak, Jack Satsangi, Marieke Pierik, Petr Ricanek, Jonas Halfvarson, Caroline L Relton, Morten H. Vatn, Christine Olbjørn, Johan D. Söderholm, and Fernando Gomollón
- Subjects
Immune system ,Immunology ,DNA methylation ,Epigenetics ,Biology - Published
- 2021
47. Maintenance therapy with infliximab or vedolizumab in IBD is not associated with increased SARS-CoV-2 seroprevalence: UK experience in the 2020 pandemic
- Author
-
Tim Ambrose, Alex Adams, Paul Klenerman, Oliver Brain, Jack Satsangi, Colleen Gc McGregor, Simon Travis, Carolina V. Arancibia-Cárcamo, Nicholas M. Croft, James O. Lindsay, Rebecca Palmer, Ross Sadler, and Alissa Walsh
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Thiopurine methyltransferase ,biology ,business.industry ,Gastroenterology ,Disease ,Infliximab ,Vedolizumab ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Maintenance therapy ,Internal medicine ,Pandemic ,Epidemiology ,medicine ,biology.protein ,Seroprevalence ,030211 gastroenterology & hepatology ,business ,medicine.drug - Abstract
We read with great interest the recent publication from Ungaro and colleagues,1 reporting the latest data from the Surveillance Epidemiology of Coronavirus Under Research Exclusion (SECURE-IBD) registry. These data, while raising concerns regarding the use of thiopurine and corticosteroid therapy in the SARS-CoV-2 pandemic, also provide valuable reassurance that monotherapy with anticytokine therapies, in particular those directed against tumour necrosis factor (TNF), are not associated with adverse outcomes in patients with IBD developing COVID-19. It has been postulated that anticytokine therapies may ameliorate or abrogate the ‘cytokine storm’ associated with severe COVID-19,2 with anti-IL6 strategies now approved for use.3 We have assessed the SARS-CoV-2 antibody seroprevalence in patients with IBD, receiving either intravenous anti-TNF therapy, or anti-integrin therapy, during the first wave of the pandemic in the UK. Sera from 640 patients attending for maintenance infliximab or vedolizumab infusions between April and June 2020 at the John Radcliffe Hospital (Oxford, UK) and Royal London Hospital (London, UK) were tested using the Abbott SARS-CoV-2 IgG assay. Adults (180) and paediatric (56) patients were included from London. Demographic and clinical data are summarised (online supplemental tables 1, 2). Key differences between the Oxford and London adult cohorts included ethnicity, smoking, comorbidities, disease type, concomitant thiopurines and biologic; in our data set, patients attending Royal London Hospital had significantly greater evidence for deprivation than Oxford (deprivation score 4 (3–6.3) vs 8 (6–9.3), p
- Published
- 2021
48. White Horse: A Novel
- Author
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Alex Adams and Alex Adams
- Published
- 2012
49. ALEX ADAMS, THE DYKE WHO WOULDN'T GROW UP.
- Author
-
CRANE, MARISA
- Subjects
WEIGHT lifting ,RECLINING chairs ,DISCOLORATION ,REGRET ,GAY bars ,LGBTQ+ bars ,WIT & humor - Abstract
* * * Again, that night, after Comet was fast asleep, Alex came to our window and off we scooted to Neverland, the world rich and glimmering before us. There was this brief period she got into a real relationship with a trauma therapist I'd kissed twice--once at Neverland, once on the sidewalk outside Neverland--but that ended after a few months because, according to Alex's followers, the Lost Dykes, as they were commonly called, Kat was trying to change Alex. We tended to sleep in just our underwear, but I wasn't covering my boobs because lord knew Alex had already seen enough of them during blackout nights at Neverland in which we'd flash everyone on the dance floor, even if they were our mortal enemy--especially if they were our mortal enemy. [Extracted from the article]
- Published
- 2023
50. P066 DNA methylation differences and methylation quantitative trait loci in primary sclerosing cholangitis and IgG4-related sclerosing cholangitis
- Author
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Alessandra Geremia, Emma L. Culver, Jack Satsangi, Alex Adams, Belén Morón-Flores, and Silvia Cabras
- Subjects
Genetics ,DNA methylation ,medicine ,Methylation ,Quantitative trait locus ,Biology ,medicine.disease ,Primary sclerosing cholangitis - Published
- 2021
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