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近日, 北京大学药学院天然药物及仿生药物国家重点实验室吕万良教授团队和北京中医药大学中药品质评价北京市 重点实验室林瑞超教授团队在国际著名学术期刊《Clinical and Translational Medicine》在线发表了题为"Schisandrin B for treatment of male infertility"的研究工作. [ABSTRACT FROM AUTHOR]

179 Journal of Chinese Pharmaceutical Sciences http://www.jcps.ac.cn The research group of Professor Wanliang Lv has made progress in the study of targeted functional liposomes against drug-resistant breast cancer 1 31 , Small -Nanostructure of functional larotaxel liposomes decorated with guanine-rich quadruplex nucleotide-lipid derivative for treatment of resistant breast cancer 180 Journal of Chinese Pharmaceutical Sciences http://www.jcps.ac.cn , , , (GT28nt) , , PEG GT28nt , , ; , JAK-STAT , , : https://onlinelibrary.wiley.com/doi/10.1002/smll.202007391 , ; ( ) 170 , 2009 2012 2019 , , Biomaterials 20 , 2004 Copyright of Journal of Chinese Pharmaceutical Sciences is the property of Journal of Chinese Pharmaceutical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. [Extracted from the article]

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Objectives: To investigate the effect and mechanism of lipid nanoparticle (LNP) delivery of small interfering RNA (siRNA) targeting Cyp2e1 gene on subacute alcoholic liver injury in mice., Methods: siRNA targeting Cyp2e1 gene was encapsulated in LNP (si-Cyp2e1 LNP) by microfluidic technique and the resulting LNPs were characterized. The optimal dose of si-Cyp2e1 LNP administration was screened. Forty female C57BL/6N mice were randomly divided into blank control group, model control group, si-Cyp2e1 LNP group, LNP control group and metadoxine group. The subacute alcoholic liver injury mouse model was induced by ethanol feeding for 10 d plus ethanol gavage for the last 3 d. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, and the superoxide dismutase (SOD) activity as well as malondialdehyde, reactive oxygen species, glutathione, triacylglycerol, total cholesterol contents in liver tissue were measured in each group, and liver index was calculated. The expression of genes related to oxidative stress, lipid synthesis and inflammation in each group of mice were measured by realtime RT-PCR., Results: Compared with the model control group, the levels of liver index, serum ALT, AST activities, malondialdehyde, reactive oxygen species, triacylglycerol, total cholesterol contents in liver tissue decreased, but the SOD activity as well as glutathione increased in the si-Cyp2e1 LNP group (all P <0.01). Hematoxylin-eosin staining result showed disorganized hepatocytes with sparse cytoplasm and a large number of fat vacuoles and necrosis in the model control group, while the si-Cyp2e1 LNP group had uniformly sized and arranged hepatocytes with normal liver tissue morphology and structure. Oil red O staining result showed si-Cyp2e1 LNP group had lower fat content of the liver compared to the model control group ( P <0.01), and no fat droplets accumulated. Anti-F4/80 monoclonal antibody fluorescence immunohistochemistry showed that the si-Cyp2e1 LNP group had lower cumulative optical density values compared to the model control group ( P <0.01) and no significant inflammatory reaction. Compared with the model control group, the expression of catalytic genes P47phox , P67phox and Gp91phox were reduced (all P <0.01), while the expression of the antioxidant enzyme genes Sod1 , Gsh - rd and Gsh - px were increased (all P <0.01). The mRNA expression of the lipid metabolism genes Pgc - 1α and Cpt1 were increased (all P <0.01) and the lipid synthesis-related genes Srebp1c , Acc and Fasn were decreased (all P <0.01); the expression of liver inflammation-related genes Tgf - β , Tnf - α and Il - 6 were decreased (all P <0.01)., Conclusions: The si-Cyp2e1 LNP may attenuate subacute alcoholic liver injury in mice mainly by reducing reactive oxygen levels, increasing antioxidant activity, blocking oxidative stress pathways and reducing ethanol-induced steatosis and inflammation.