3,720 results on '"*RISK factors of skin cancer"'
Search Results
2. Risk Factors for Skin Cancer in the Salud Delicias Area
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Yanet Hernández Caballero, María del Carmen Pérez Cuesta, Leticia Rómulo Ávila, and Yoenny Peña García
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cáncer de piel ,estilos de vida saludables ,factores de riesgo ,Internal medicine ,RC31-1245 ,Special situations and conditions ,RC952-1245 - Abstract
Background: skin cancer has a high incidence, with an upward trend worldwide. These carcinomas are preventable both by lifestyle changes and by detecting lesions indicative of malignant transformation.Objective: to determine the risk factors for skin cancer in the population of office number 4 of the Delicias Health Area.Method: an epidemiological, observational, analytical study of cases and controls was carried out in the period 2017-2021. The study population consisted of 13 patients (case group) and 26 patients (control group), for a total of 39 cases included, all over 15 years of age. The variables were studied: age, sex, skin color, occupation, time of exposure to the sun, means of protection, contact with chemical substances. The information was obtained from the medical records and a questionnaire, it was analyzed through the percentage calculation, the Chi2 and the odd ratio.Results: participants older than 55 years (38.5 %), male sex (69.2 %) predominated. They had a higher risk of skin cancer: those with white skin color (Chi2: 3.3; OR: 6.4; pConclusions: those over 55 years of age and men predominated, a statistical and causal association was demonstrated between skin cancer and the risk factors studied.
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- 2022
3. An epidemiological study of the association between risk factors and skin cancer incomplete excisions
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João Vitor Pithon Napoli and Gabriela Ducioni Matos
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skin neoplasms ,dermatology ,plastics ,/pathology ,margins of excision ,Surgery ,RD1-811 - Abstract
Introduction: The increasing incidence of skin cancer leads to a high number of surgical procedures worldwide. The surgical treatment of skin cancer's main objective is its complete excision, preserving the function and the best aesthetic result. Incomplete initial resection can result in recurrences and major damage. The objective is to analyze the risk factors for positive margins in the follow-up of cutaneous lesions surgically removed, for one year, in the plastic surgery department of the Royal Perth Hospital. Methods: A survey of histopathological samples from 947 operated patients was analyzed. All patients with confirmed incomplete excision (IE) underwent a second surgery or even a third time. Results: In total, 947 lesions were found, 6.6% of surgeries had compromised margins, with a histopathological distribution of 75% of basal cell carcinoma, 21.4% of squamous cell carcinoma, and 3.6% of other lesions. The relation of the presence of compromised surgical margins between the SCC, compared to BCC, leads to a relative risk of 2.8 and a p-value of 0.041, which suggests that the SCC is a risk factor for the presence of compromised surgical margins. For staging, the need for a second surgical approach was present in 61.29% of the patients, 20.9% were under observation, 3.2% were absent from the service, 8% went directly to chemotherapy or radiotherapy, and 6.4% rescheduled the surgery. Conclusion: Knowledge of risk factors for positive margins is necessary for the surgeon to understand the prognosis and monitoring of each patient.
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- 2021
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4. Supplemental material from Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study
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Wu, Shaowei, primary, Han, Jiali, primary, Laden, Francine, primary, and Qureshi, Abrar A., primary
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- 2023
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5. Data from Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study
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Wu, Shaowei, primary, Han, Jiali, primary, Laden, Francine, primary, and Qureshi, Abrar A., primary
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- 2023
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6. AVALIAÇÃO DO CONHECIMENTO DE ACADÊMICOS DE MEDICINA SOBRE FOTOPROTEÇÃO E FATORES DE RISCO PARA O CÂNCER DE PELE.
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ROSA MAIA GUERRA, FERNANDO MARCOS, MARQUES NOBRE, LEANDRA FERREIRA, and SANTOS VAZ, DIANA SOUZA
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"Non-melanoma" skin cancer is the most common neoplasm worldwide. It is noteworthy that skin cancer is on the rise around the world and symbolizes high social and financial costs for society, as well as for the health system. However, it is a preventable disease. It is believed that academics in the health area should be proactive agents in primary health care activities, including practices for the prevention of skin cancer. For this, it is necessary that the academic is updated with the protocols regarding this topic. The objective of this work is to evaluate the knowledge of academics in the health area regarding the use of photoprotection and the risk factors for skin cancer. The study population was predominantly composed of young students, with a mean age of 22 years, female, with fair skin and dark hair and eyes. The research revealed discrepancies between knowledge and practice of photoprotective measures in the daily lives of these students. However, the results obtained bring benefits, revealing the critical-reflexive need for the participants. [ABSTRACT FROM AUTHOR]
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- 2022
7. RISK FACTORS AND SKIN CANCER IN ADULTS FROM THE CITY OF MACHALA - ECUADOR
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Guerrero, Edmo Ramiro Jara, primary, Alarcón, Parrasqueby Loukidis, additional, Mora, María Belén Alvarado, additional, and González, Darwin Daniel Campos, additional
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- 2022
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8. Data from Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study
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Abrar A. Qureshi, Francine Laden, Jiali Han, and Shaowei Wu
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Background: Few prospective studies have examined the relationship between sun exposure, other potential risk factors, and risk of different skin cancers [including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma] simultaneously.Methods: We evaluated the association between a number of potential risk factors and skin cancer risk in a cohort of 108,916 US women, the Nurses' Health Study II (1989–2009).Results: During 2.05 million years of follow-up, we identified 6,955, 880, and 779 diagnoses of BCC, SCC, and melanoma, respectively. Compared with participants in the lowest quintile of cumulative ultraviolet flux in adulthood, participants in the highest quintile had multivariable-adjusted relative risks (RR) of 2.35 (Ptrend < 0.0001) for BCC, 2.53 (Ptrend = 0.009) for SCC, and 0.68 (Ptrend = 0.38) for melanoma. In contrast, the RRs were 1.68 (95% CI, 1.55–1.82) for BCC, 1.68 (95% CI, 1.34–2.11) for SCC, and 1.80 (95% CI, 1.42–2.28) for melanoma for participants with ≥5 blistering sunburns when compared with participants without sunburn between ages 15 and 20 years. We found significant interactions between family history of melanoma, number of blistering sunburns between ages 15 and 20 years and BCC risk, and between sunburn reaction as a child/adolescent and SCC risk (all Pinteraction < 0.05).Conclusion: In a cohort of U.S. women, we found that sun exposures in both early life and adulthood were predictive of BCC and SCC risks, whereas melanoma risk was predominantly associated with sun exposure in early life.Impact: Our results may have potential implications for the prevention of skin cancers. Cancer Epidemiol Biomarkers Prev; 23(6); 1080–9. ©2014 AACR.
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- 2023
9. Supplemental material from Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study
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Abrar A. Qureshi, Francine Laden, Jiali Han, and Shaowei Wu
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Supplemental Table 1. Relative risks of basal cell carcinoma according to quintiles of cumulative UV flux stratified potential risk factors in the Nurses' Health Study II (1989-2009). Supplemental Table 2. Relative risks of squamous cell carcinoma according to quintiles of cumulative UV flux stratified by sunburn reaction as a child/adolescent in the Nurses' Health Study II (1989-2009). Supplemental Table 3. Relative risks of skin cancer according to quintiles of cumulative UV flux stratified by host risk score in the Nurses' Health Study II (1989-2009). Supplemental Figure 1. A directed acyclic graph showing the relationships between sun exposure, other potential risk factors, and risk of skin cancer.
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- 2023
10. Occupational risk factors for skin cancer and the availability of sun protection measures at German outdoor workplaces
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Ruppert, Linda, Ofenloch, Robert, Surber, Christian, and Diepgen, Thomas
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- 2016
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11. Incidence of and Risk Factors for Skin Cancer in Organ Transplant Recipients in the United States
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Garrett, Giorgia L., Blanc, Paul D., Boscardin, John, Lloyd, Amanda Abramson, Ahmed, Rehana L., Anthony, Tiffany, Bibee, Kristin, Breithaupt, Andrew, Cannon, Jennifer, Chen, Amy, Cheng, Joyce Y., Chiesa-Fuxench, Zelma, Colegio, Oscar R, Curiel-Lewandrowski, Clara, Del Guzzo, Christina A., Disse, Max, Dowd, Margaret, Eilers, Robert, Jr, Ortiz, Arisa Elena, Morris, Caroline, Golden, Spring K., Graves, Michael S., Griffin, John R., Hopkins, R. Samuel, Huang, Conway C., Bae, Gordon Hyeonjin, Jambusaria, Anokhi, Jennings, Thomas A., Jiang, Shang I. Brian, Karia, Pritesh S., Khetarpal, Shilpi, Kim, Changhyun, Klintmalm, Goran, Konicke, Kathryn, Koyfman, Shlomo A., Lam, Charlene, Lee, Peter, Leitenberger, Justin J., Loh, Tiffany, Lowenstein, Stefan, Madankumar, Reshmi, Moreau, Jacqueline F., Nijhawan, Rajiv I., Ochoa, Shari, Olasz, Edit B., Otchere, Elaine, Otley, Clark, Oulton, Jeremy, Patel, Parth H., Patel, Vishal Anil, Prabhu, Arpan V., Pugliano-Mauro, Melissa, Schmults, Chrysalyne D., Schram, Sarah, Shih, Allen F., Shin, Thuzar, Soon, Seaver, Soriano, Teresa, Srivastava, Divya, Stein, Jennifer A., Sternhell-Blackwell, Kara, Taylor, Stan, Vidimos, Allison, Wu, Peggy, Zajdel, Nicholas, Zelac, Daniel, and Arron, Sarah T.
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- 2017
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12. Fotoexposição e fatores de risco para câncer da pele: uma avaliação de hábitos e conhecimentos entre estudantes universitários Photoexposure and risk factors for skin cancer: an evaluation of behaviors and knowledge among university students
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Ivan Gagliardi Castilho, Maria Aparecida Alves Sousa, and Rubens Marcelo Souza Leite
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Estudantes ,Fatores de Risco ,Neoplasias Cutâneas ,Protetores de Raios Solares ,Raios Ultravioleta ,Students ,Risks Factors ,Skin Neoplasms ,Sunscreening Agents ,Ultraviolet Rays ,Dermatology ,RL1-803 - Abstract
FUNDAMENTOS: O câncer da pele é a neoplasia mais frequente no Brasil. Compreender as atitudes que influenciam a proteção e a exposição aos raios solares é extremamente importante para sua prevenção. OBJETIVOS: Avaliar hábitos de fotoexposição e fotoproteção, bem como conhecimento de fatores de risco para câncer da pele, tendo por fim delinear os padrões de comportamento dos jovens perante os efeitos solares. MÉTODOS: Distribuíram-se questionários autoaplicativos a 368 universitários, na faixa etária dos 20 anos, dos cursos de Medicina, Educação Física, Direito e Comunicação Social de instituição de ensino privada em Taguatinga (DF). RESULTADOS: O uso diário de fotoprotetor foi significativamente maior entre as mulheres. A prática de bronzeamento artificial foi baixa (3,5%), referida apenas por mulheres. O uso de filtro solar com fator de proteção maior do que 15 ou igual a 15 foi referido por 278 estudantes. De modo geral, mais de 90% dos estudantes acreditam na associação entre radiação ultravioleta e câncer da pele. Apesar disso, apenas 43,5% acreditam na genética como fator de risco. Entre os que rejeitam a hipótese do fator de risco genético para carcinogênese cutânea, 86,2% são acadêmicos das Ciências Humanas (Direito e Comunicação Social). CONCLUSÃO: Esses dados permitem orientar medidas nos níveis individual e coletivo, colaborando para a prevenção de lesões cutâneas.BACKGROUND: Skin cancer is the most common neoplasm in Brazil. It is extremely important to understand the attitudes that influence protection from and exposure to the sun's ultraviolet rays in order to prevent this clinical condition. OBJECTIVES: To evaluate photoexposure and photoprotection habits and knowledge of risk factors for skin cancer, with the purpose of describing behavioral patterns of university students in relation to the effects of the sun. METHODS: Self-administered questionnaires were distributed to 368 students, aged 20-29 years, from courses in the areas of Medicine, Physical Education, Law and Social Communication, in a private education institution in Taguatinga-DF.. RESULTS: The daily use of photoprotector was significantly higher among women. The use of tanning beds was low (3.5%), and was mentioned only by women. The application of sunscreen with sun protection factor (SPF) equal to or greater than 15 was reported by 278 students. In general, over 90% of the students believe in the association between ultraviolet radiation and skin cancer. Nevertheless, only 43.5% believe in genetics as a risk factor. Among those who reject genetics as a risk factor for skin cancer, 86.2% are Human Sciences students (Law and Social Communication). CONCLUSION: Results may help the establishment of individual and collective preventive measures, helping to avoid skin lesions.
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- 2010
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13. An epidemiological study of the association between risk factors and skin cancer incomplete excisions
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NAPOLI, JOÃO VITOR PITHON, primary and MATOS, GABRIELA DUCIONI, additional
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- 2021
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14. Risk factors for skin cancer and solid tumors in newly diagnosed patients with chronic lymphocytic leukemia and the impact of skin surveillance on survival.
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Ishdorj, Ganchimeg, Beiggi, Sara, Nugent, Zoann, Streu, Erin, Banerji, Versha, Dhaliwal, Dhali, Mahmud, Salah M., Marshall, Aaron J., Gibson, Spencer B., Wiseman, Marni C., and Johnston, James B.
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CHRONIC lymphocytic leukemia , *SKIN cancer , *TUMORS , *CANCER chemotherapy , *SKIN - Abstract
A retrospective analysis on 587 patients with chronic lymphocytic leukemia (CLL) assessed risk factors for skin cancer and the influence of skin cancers on survival and incidence of solid tumors (STs). Patients underwent skin surveillance and were followed for a median of 6.65 years. The relative risk for skin cancer increased prior to CLL diagnosis rising 4-fold one-year post-diagnosis. Independent predictors for skin cancer were male gender (p =.0001), age ≥70 years (p =.0036) and prior chemotherapy (p =.0116). There was no increase in mortality from skin cancer and neither skin cancer nor chemotherapy increased the risk for a ST. The development of a ST was an independent predictor of survival (p <.0001) and 43% of deaths were related to STs. Thus, regular skin surveillance can prevent increased mortality from skin cancer, but not STs, in CLL. Close skin monitoring is required for elderly males who received chemotherapy. [ABSTRACT FROM AUTHOR]
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- 2019
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15. Incidence and risk factors for skin cancer following lung transplantation
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Rashtak, Shadi, Dierkhising, Ross A., Kremers, Walter K., Peters, Steve G., Cassivi, Stephen D., and Otley, Clark C.
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- 2015
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16. Good, but Not Perfect: Parental Knowledge About Risk Factors for Skin Cancer and the Necessity of Sun Protection in Southern Germany
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Gefeller, Olaf, Uter, Wolfgang, and Pfahlberg, Annette B.
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- 2015
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17. Do Patients With End-Stage Chronic Renal Failure Treated With the Use of Hemodialysis Have Healthy Skin? Evaluation of Skin Lesions and Basic Education About Risk Factors for Skin Cancer in This Patient Population.
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Ankudowicz, A., Król, E., and Dębska-Ślizień, A.
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TREATMENT of chronic kidney failure , *HEMODIALYSIS , *RISK factors of skin cancer , *DISEASE incidence , *KIDNEY transplantation - Abstract
Background Considering the increasing incidence of skin cancers in patients after renal transplantation, evaluation of skin condition in dialysis patients, from whom kidney transplant recipients are recruited, appears to be very important. Particular importance is attached to the identification of such dialysis patients in the population who require dermatologic care before qualifying for transplantation. The objective of this study was to determine the prevalence of skin diseases in the dialysis patient population. Education of the patients regarding risk factors for skin cancer and the need for sun protection was performed. Methods Full dermatologic examination, including dermatoscopy, was performed on a group of 77 dialysis patients (38 women, 39 men) and a control group of 77 healthy people (60 women, 17 men). Results Eight hemodialysis patients had healthy skin compared with 33 people from the control group. In the remaining hemodialysis patients, the following skin lesions were observed: 1) inflammatory and allergic skin disorders in 17 patients; 2) bacterial, fungal, and viral infections in 26 patients; 3) benign lesions in 39 patients; 4) malignant skin lesions and precancerous conditions in 4 patients; and 5) other skin changes in 63 patients. Conclusions Skin lesions are common in the dialysis patient population. Only 10% of the examined population had completely healthy skin, compared with 43% of the control group. More than one-half of dialysis patients required dermatologic care compared with one-third of healthy control subjects. [ABSTRACT FROM AUTHOR]
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- 2016
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18. Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study.
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Shaowei Wu, Jiali Han, Laden, Francine, and Qureshi, Abrar A.
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The article discusses a study to examine the relationship between sun exposure, other potential risk factors, and risk of different skin cancers including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. Topics discussed include constitutional risk factors of skin cancer including family history, red hair color, and melanocytic nevi, calculation of body mass index for the study, and potential risk factors for melanoma including alcohol intake, and physical activity.
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- 2014
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19. Epigenetic and Environmental Risk Factors in Skin Cancer
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- 2020
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20. Risk Factors for Skin Cancer among Finnish Airline Cabin Crew
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Kojo, Katja, Helminen, Mika, Pukkala, Eero, and Auvinen, Anssi
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- 2013
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21. Known and potential new risk factors for skin cancer in European populations: a multicentre case–control study
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de Vries, E., Trakatelli, M., Kalabalikis, D., Ferrandiz, L., Ruiz-de-Casas, A., Moreno-Ramirez, D., Sotiriadis, D., Ioannides, D., Aquilina, S., Apap, C., Micallef, R., Scerri, L., Ulrich, M., Pitkänen, S., Saksela, O., Altsitsiadis, E., Hinrichs, B., Magnoni, C., Fiorentini, C., Majewski, S., Ranki, A., Stockfleth, E., and Proby, C.
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- 2012
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22. Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can)
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Nagel, G., Bjrge, T., Stocks, T., Manjer, J., Hallmans, G., Edlinger, M., Häggström, C., Engeland, A., Johansen, D., Kleiner, A., Selmer, R., Ulmer, H., Tretli, S., Jonsson, H., Concin, H., Stattin, P., and Lukanova, A.
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- 2012
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23. Risk factors for skin cancer and solid tumors in newly diagnosed patients with chronic lymphocytic leukemia and the impact of skin surveillance on survival
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James B. Johnston, Salah Mahmud, Sara Beiggi, Marni C. Wiseman, Erin Streu, Spencer B. Gibson, Dhali H.S. Dhaliwal, Aaron J. Marshall, Versha Banerji, Ganchimeg Ishdorj, and Zoann Nugent
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Male ,Cancer Research ,medicine.medical_specialty ,Skin Neoplasms ,Chronic lymphocytic leukemia ,Newly diagnosed ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Risk Factors ,hemic and lymphatic diseases ,medicine ,Retrospective analysis ,Humans ,Referral and Consultation ,Early Detection of Cancer ,Aged ,Retrospective Studies ,integumentary system ,business.industry ,Incidence (epidemiology) ,Incidence ,Age Factors ,Neoplasms, Second Primary ,Hematology ,Middle Aged ,medicine.disease ,Dermatology ,Leukemia, Lymphocytic, Chronic, B-Cell ,humanities ,Oncology ,030220 oncology & carcinogenesis ,Skin surveillance ,Practice Guidelines as Topic ,Female ,Skin cancer ,business ,030215 immunology ,Follow-Up Studies - Abstract
A retrospective analysis on 587 patients with chronic lymphocytic leukemia (CLL) assessed risk factors for skin cancer and the influence of skin cancers on survival and incidence of solid tumors (STs). Patients underwent skin surveillance and were followed for a median of 6.65 years. The relative risk for skin cancer increased prior to CLL diagnosis rising 4-fold one-year post-diagnosis. Independent predictors for skin cancer were male gender (
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- 2019
24. Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can)
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Background Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC). Objectives To assess the associations between metabolic factors (both individually and combined) and the risk of skin cancer in the large prospective Metabolic Syndrome and Cancer Project (Me-Can). Methods During a mean follow-up of 12 years of the Me-Can cohort, 1728 (41% women) incident MM, 230 (23% women) fatal MM and 1145 (33% women) NMSC were identified. Most NMSC cases (76%) were squamous cell carcinoma (SCC) (873, 33% women). Hazard ratios (HRs) were estimated by Cox proportional hazards regression for quintiles and standardized z-scores (with a mean of 0 and SD of 1) of body mass index (BMI), blood pressure, glucose, cholesterol, triglycerides and for a combined metabolic syndrome score. Risk estimates were corrected for random error in the measurements. Results Blood pressure per unit increase of z-score was associated with an increased risk of incident MM cases in men and women [HR 1·17, 95% confidence interval (CI) 1·04-1·31 and HR 1·18, 95% CI 1·03-1·36, respectively] and fatal MM cases among women (HR 2·39, 95% CI 1·58-3·64). In men, all quintiles for BMI above the reference were associated with a higher risk of incident MM. In women, SCC NMSC risk increased across quintiles for glucose levels (P-trend 0·02) and there was a trend with triglyceride concentration (P-trend 0·09). Conclusion These findings suggest that mechanisms linked to blood pressure may be involved in the pathogenesis of MM. SCC NMSC in women could be related to glucose and lipid metabolism.
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- 2012
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25. Incidence of and Risk Factors for Skin Cancer After Heart Transplant
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Brewer, Jerry D., Colegio, Oscar R., Phillips, P. Kim, Roenigk, Randall K., Jacobs, M. Amanda, Van de Beek, Diederik, Dierkhising, Ross A., Kremers, Walter K., McGregor, Christopher G., and Otley, Clark C.
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- 2009
26. Environmental Risk Factors for Skin Cancer
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Urbach, F., primary
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- 1993
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27. Rheumatoid arthritis and TNF antagonists as risk factors for skin cancer
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Murphy, Rachel
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- 2006
28. Occupational risk factors for skin cancer and the availability of sun protection measures at German outdoor workplaces
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Christian Surber, Thomas L. Diepgen, Robert Ofenloch, and Linda Ruppert
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Male ,Skin Neoplasms ,Ultraviolet Rays ,Sun protection ,Occupational risk ,education ,Occupational disease ,Protective factor ,Health Services Accessibility ,Administrative controls ,German ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Germany ,Occupational Exposure ,Environmental health ,medicine ,Humans ,Sunburn ,Students ,Workplace ,skin and connective tissue diseases ,Schools ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,030210 environmental & occupational health ,language.human_language ,Occupational Diseases ,Cross-Sectional Studies ,language ,Female ,Skin cancer ,business ,Sunscreening Agents - Abstract
Germany implemented a new occupational disease “squamous cell carcinoma or multiple actinic keratosis due to natural UV radiation (UVR)” into the German ordinance on occupational diseases. Since primary prevention is very important, the aim of this study was to assess the provision of sun protection measures by the employers in vocational school students for outdoor professions. We conducted a cross-sectional study on the availability of sun protection measures at German workplaces and the risk of occupational sunburn by surveying 245 vocational school students working in outdoor occupations. More than 40 % of the students did not receive any sun protection measures by their employer, and 34.5 % of the students got sunburned during work. Working in the shade was a protective factor for occupational sunburn but was merely available for 23.7 % of the outdoor workers. Our study reveals a strong need for effective sun protection measures, including both administrative controls like education and personal protection measures at German outdoor workplaces.
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- 2016
29. Studying risk factors for skin cancer development
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Оlena О, Оshyvalova
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Aged, 80 and over ,Keratosis, Actinic ,Male ,Skin Neoplasms ,Risk Factors ,Carcinoma, Squamous Cell ,Humans ,Female ,Middle Aged ,Medical History Taking ,Sunscreening Agents ,Aged - Abstract
In most countries with a population of mainly European origin, non-melanoma skin carcinoma incidence rate has increased over the last decade. Understanding of what is the best way to identify people at high risk for skin cancer development will help to optimize the strategy for prevention and treatment tactics. Aim of the research involves studying risk factors for skin cancer development in patients with cutaneous squamous cell carcinoma and squamous cell carcinoma in situ (cSCC and SCCis correspondingly) and patients with actinic keratosis (AK).we conducted a survey of patients with cSCC, SCCis and AK who had been under case follow-up at the State Scientific Institution "Scientific and Practical Centre of Preventive and Clinical Medicine" of the State Administration (hereinafter SIS) during 2014-2016.Clinical diagnosis in 100% of cases was confirmed by pathomorphological study. Statistical processing of the obtained data was performed using STATISTICA 7.0 programme.The questionnaire involved 129 patients, including 21(16.3%) patient with cSCC, 40 (31%) patients with SCCis, 57 (44.2%) patients with AK and 11 (8.5%) patients who had mentioned above combined pathology i.e. cSCC, SCCis and АК at the same time. Only two studied risk factors for skin cancer development were found to have influence on the skin pathology: "Not using sun-protection preparation for the skin" and "Burdened family history of thefirst level of relationship".In forming the risk groups for skin cancer development it is advisable to consider burdened family history and using sun-protection preparation for the skin.
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- 2017
30. Faculty Opinions recommendation of Incidence of and risk factors for skin cancer in organ transplant recipients in the united states.
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Leffell, David, primary
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- 2017
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31. Investigators from University of Zurich Zero in on Skin Cancer (Occupational risk factors for skin cancer and the availability of sun protection measures at German outdoor workplaces)
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Sunscreening agents -- Health aspects ,Physical fitness -- Health aspects ,Cancer prevention -- Health aspects ,Skin cancer -- Risk factors -- Health aspects ,Health ,University of Zurich - Abstract
2016 AUG 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Oncology. According to news reporting originating in [...]
- Published
- 2016
32. Studying risk factors for skin cancer development.
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Оshyvalova ОО
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- Aged, Aged, 80 and over, Carcinoma, Squamous Cell epidemiology, Female, Humans, Male, Medical History Taking, Middle Aged, Risk Factors, Skin Neoplasms epidemiology, Sunscreening Agents, Carcinoma, Squamous Cell etiology, Keratosis, Actinic, Skin Neoplasms etiology
- Abstract
Introduction: In most countries with a population of mainly European origin, non-melanoma skin carcinoma incidence rate has increased over the last decade. Understanding of what is the best way to identify people at high risk for skin cancer development will help to optimize the strategy for prevention and treatment tactics. Aim of the research involves studying risk factors for skin cancer development in patients with cutaneous squamous cell carcinoma and squamous cell carcinoma in situ (cSCC and SCCis correspondingly) and patients with actinic keratosis (AK)., Materials and Methods: we conducted a survey of patients with cSCC, SCCis and AK who had been under case follow-up at the State Scientific Institution "Scientific and Practical Centre of Preventive and Clinical Medicine" of the State Administration (hereinafter SIS) during 2014-2016.Clinical diagnosis in 100% of cases was confirmed by pathomorphological study. Statistical processing of the obtained data was performed using STATISTICA 7.0 programme., Results: The questionnaire involved 129 patients, including 21(16.3%) patient with cSCC, 40 (31%) patients with SCCis, 57 (44.2%) patients with AK and 11 (8.5%) patients who had mentioned above combined pathology i.e. cSCC, SCCis and АК at the same time. Only two studied risk factors for skin cancer development were found to have influence on the skin pathology: "Not using sun-protection preparation for the skin" and "Burdened family history of thefirst level of relationship"., Conclusions: In forming the risk groups for skin cancer development it is advisable to consider burdened family history and using sun-protection preparation for the skin.
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- 2017
33. Phenotipic pigmentary traits – important risk factors for skin cancer
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Alina Avram, Bucureşti Universitatea de Medicină şi Farmacie „Carol Davila', Clinica I Dermatologie, Spitalul Clinic Colentina, Bucureşti, and Mariana Grigore
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medicine.medical_specialty ,integumentary system ,business.industry ,Materials Chemistry ,medicine ,Skin cancer ,business ,medicine.disease ,Dermatology - Abstract
Prevention and early detection in skin cancer are of utmost importance as they increase survival rates, life quality indicators and overall prognosis. In order to achieve an optimal primary prophylaxis one must first know and recognise documented risk factors. The colour of skin, hair and eyes were linked to the risk of developing skin cancer and are easy to evaluate morphologic traits. Pigmentary phenotypic traits are used worldwide to evaluate an individual’s risk for cutaneous carcinogenesis. A high number of epidemiologic studies highlight the importance of skin type as an independent skin cancer risk factor, fair skin and the inability to tan being frequent characteristics of patients suffering from this pathology. Regarding eye colour, there is less scientific data available, but most published studies link light irises to the risk of developing skin cancer.
- Published
- 2015
34. Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study
- Author
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Jiali Han, Shaowei Wu, Abrar A. Qureshi, and Francine Laden
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Skin Neoplasms ,Ultraviolet Rays ,Epidemiology ,Article ,Cohort Studies ,Risk Factors ,Internal medicine ,medicine ,Humans ,Basal cell carcinoma ,Sunburn ,skin and connective tissue diseases ,Prospective cohort study ,neoplasms ,integumentary system ,business.industry ,Cancer ,medicine.disease ,Surgery ,Relative risk ,Cohort ,Female ,Skin cancer ,business ,Cohort study - Abstract
Background: Few prospective studies have examined the relationship between sun exposure, other potential risk factors, and risk of different skin cancers [including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma] simultaneously. Methods: We evaluated the association between a number of potential risk factors and skin cancer risk in a cohort of 108,916 US women, the Nurses' Health Study II (1989–2009). Results: During 2.05 million years of follow-up, we identified 6,955, 880, and 779 diagnoses of BCC, SCC, and melanoma, respectively. Compared with participants in the lowest quintile of cumulative ultraviolet flux in adulthood, participants in the highest quintile had multivariable-adjusted relative risks (RR) of 2.35 (Ptrend < 0.0001) for BCC, 2.53 (Ptrend = 0.009) for SCC, and 0.68 (Ptrend = 0.38) for melanoma. In contrast, the RRs were 1.68 (95% CI, 1.55–1.82) for BCC, 1.68 (95% CI, 1.34–2.11) for SCC, and 1.80 (95% CI, 1.42–2.28) for melanoma for participants with ≥5 blistering sunburns when compared with participants without sunburn between ages 15 and 20 years. We found significant interactions between family history of melanoma, number of blistering sunburns between ages 15 and 20 years and BCC risk, and between sunburn reaction as a child/adolescent and SCC risk (all Pinteraction < 0.05). Conclusion: In a cohort of U.S. women, we found that sun exposures in both early life and adulthood were predictive of BCC and SCC risks, whereas melanoma risk was predominantly associated with sun exposure in early life. Impact: Our results may have potential implications for the prevention of skin cancers. Cancer Epidemiol Biomarkers Prev; 23(6); 1080–9. ©2014 AACR.
- Published
- 2014
35. CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation.
- Author
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van der Weyden, Louise, Harle, Victoria, Turner, Gemma, Offord, Victoria, Iyer, Vivek, Droop, Alastair, Swiatkowska, Agnieszka, Rabbie, Roy, Campbell, Andrew D., Sansom, Owen J., Pardo, Mercedes, Choudhary, Jyoti S., Ferreira, Ingrid, Tullett, Mark, Arends, Mark J., Speak, Anneliese O., and Adams, David J.
- Subjects
- *
RISK factors of skin cancer , *CANCER-related mortality , *CRISPRS , *MEMBRANE proteins , *DRUG target , *MELANOMA - Abstract
Melanoma represents ~5% of all cutaneous malignancies, yet accounts for the majority of skin cancer deaths due to its propensity to metastasise. To develop new therapies, novel target molecules must to be identified and the accessibility of cell surface proteins makes them attractive targets. Using CRISPR activation technology, we screened a library of guide RNAs targeting membrane protein-encoding genes to identify cell surface molecules whose upregulation enhances the metastatic pulmonary colonisation capabilities of tumour cells in vivo. We show that upregulated expression of the cell surface protein LRRN4CL led to increased pulmonary metastases in mice. Critically, LRRN4CL expression was elevated in melanoma patient samples, with high expression levels correlating with decreased survival. Collectively, our findings uncover an unappreciated role for LRRN4CL in the outcome of melanoma patients and identifies a potential therapeutic target and biomarker. Louise van der Weyden et al. report a CRISPRa screen in mice to identify membrane protein-encoding genes that, when overexpressed, enhance the metastatic potential of melanoma cells. They find that high expression of LRRN4CL in melanoma cells increases lung metastases in mice and correlates with poorer survival in melanoma patients, suggesting it could be a promising drug target. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
36. The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin.
- Author
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Hernando, B., Dietzen, M., Parra, G., Gil-Barrachina, M., Pitarch, G., Mahiques, L., Valcuende-Cavero, F., McGranahan, N., and Martinez-Cadenas, C.
- Subjects
- *
RISK factors of skin cancer , *GENETIC mutation , *PHYSIOLOGICAL effects of solar radiation , *SKIN biopsy , *PHYSIOLOGICAL effects of ultraviolet radiation , *SQUAMOUS cell carcinoma ,AGE factors in cancer - Abstract
The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also contribute to skin cancer risk. This study aimed at exploring the role of photoaging, as well as other well-known epidemiological risk factors, in the accumulation of somatic mutations in cancer-free human epidermis. We deeply sequenced 46 genes in normal skin biopsies from 123 healthy donors, from which phenotypic data (including age, pigmentation-related genotype and phenotype) and sun exposure habits were collected. We determined the somatic mutational burden, mutational signatures, clonal selection and frequency of driver mutations in all samples. Our results reveal an exponential accumulation of UV-related somatic mutations with age, matching skin cancer incidence. The increase of mutational burden is in turn modified by an individual's skin phototype. Somatic mutations preferentially accumulated in cutaneous squamous cell carcinoma cancer genes and clonally expanded with age, with distinct mutational processes underpinning different age groups. Our results suggest a loss of fidelity in transcription-coupled repair later in life. Our findings reveal that ageing is not only associated with an exponential increase in the number of somatic mutations accumulated in normal epidermis, but also with selection and expansion of cancer-associated mutations. Aged, sun-exposed normal skin is thus an extended mosaic of multiple clones with driver mutations, poised for the acquisition of transforming events. • As skin cancer incidence increases, UV-related somatic mutations accumulate exponentially with increasing age in normal epidermis. • UV-related mutations do not only accumulate with age, but also repair processes are less efficient in elderly individuals. • Apart from age, an individual's skin phototype is key in the build-up of somatic mutations in healthy skin. • Distinct mutational processes may operate in different age groups. • Ageing is associated with positive selection and expansion of clones with cancer mutations in sun-exposed normal skin. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
37. Study identifies post-HCT risk factors for skin cancer
- Author
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Rans, Caleb
- Subjects
Hematopoietic stem cell transplantation -- Health aspects ,Cancer research -- Health aspects ,Skin cancer -- Risk factors -- Health aspects ,Chronic lymphocytic leukemia ,Lymphocytic leukemia ,Surgery ,Medical centers ,Medical research ,Biochemistry ,Health ,Health care industry - Abstract
Previously unknown risk factors for secondary skin cancer linked with allogeneic hematopoietic cell transplantation (HCT) have been identified, researchers report after a retrospective analysis. 'We confirmed [graft-versus-host disease] as a [...]
- Published
- 2019
38. Do Patients With End-Stage Chronic Renal Failure Treated With the Use of Hemodialysis Have Healthy Skin? Evaluation of Skin Lesions and Basic Education About Risk Factors for Skin Cancer in This Patient Population
- Author
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Alicja Dębska-Ślizień, A. Ankudowicz, and Ewa Król
- Subjects
Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,medicine.medical_treatment ,Population ,Skin Diseases ,Renal Dialysis ,Risk Factors ,Internal medicine ,Prevalence ,Medicine ,Humans ,education ,Dialysis ,Transplantation ,Dermatoscopy ,education.field_of_study ,integumentary system ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Case-control study ,Middle Aged ,medicine.disease ,Surgery ,Case-Control Studies ,Kidney Failure, Chronic ,Female ,Hemodialysis ,Skin cancer ,business - Abstract
Background Considering the increasing incidence of skin cancers in patients after renal transplantation, evaluation of skin condition in dialysis patients, from whom kidney transplant recipients are recruited, appears to be very important. Particular importance is attached to the identification of such dialysis patients in the population who require dermatologic care before qualifying for transplantation. The objective of this study was to determine the prevalence of skin diseases in the dialysis patient population. Education of the patients regarding risk factors for skin cancer and the need for sun protection was performed. Methods Full dermatologic examination, including dermatoscopy, was performed on a group of 77 dialysis patients (38 women, 39 men) and a control group of 77 healthy people (60 women, 17 men). Results Eight hemodialysis patients had healthy skin compared with 33 people from the control group. In the remaining hemodialysis patients, the following skin lesions were observed: 1) inflammatory and allergic skin disorders in 17 patients; 2) bacterial, fungal, and viral infections in 26 patients; 3) benign lesions in 39 patients; 4) malignant skin lesions and precancerous conditions in 4 patients; and 5) other skin changes in 63 patients. Conclusions Skin lesions are common in the dialysis patient population. Only 10% of the examined population had completely healthy skin, compared with 43% of the control group. More than one-half of dialysis patients required dermatologic care compared with one-third of healthy control subjects.
- Published
- 2015
39. Sun exposure and health safety practices of high school students in an urban population of Iran.
- Author
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Janjani, Hosna, Nedjat, Saharnaz, MasoudYunesian, Nasseri, Simin, Haghighat Doost, Fatemeh, and Nabizadeh, Ramin
- Subjects
- *
HIGH school students , *RISK factors of skin cancer , *PHYSIOLOGICAL effects of solar radiation , *CROSS-sectional method - Abstract
Background: Skin cancer attributed to sunlight exposure has an increasing trend worldwide, resulting in increased problems for healthcare services. This study aimed to evaluate the health safety practices of high school students in Saveh, Iran according to a sun protection guideline produced locally for Iran.Method: This cross-sectional study was done in 31 government and private high schools of Saveh, a central city of Iran. A sun protection questionnaire was designed in accordance with Iran sun protection guideline which has been developed based on the World Health Organization and US Environmental Protection Agency guidelines. The questionnaire consists of four sections of demographic information, knowledge, attitude, and protection behavior. A total of 504 students were selected by simple random sampling method. Pearson correlation coefficient and multiple linear regression analysis were used to assess the correlation between knowledge, attitude and behavior of the participants.Results: The mean score of the students' knowledge, attitude, and behavior regarding harmfulness of ultraviolet radiation was 50.79 ± 14.64, 60.41 ± 15.04, and 45 ± 11.59, respectively. A significant association was observed between attitude and knowledge, behavior and knowledge as well as attitude. There was a significant correlation between sex and protective behaviors, sex and knowledge (p ≤ 0.001), and education level and knowledge (p = 0.002).Conclusion: students who protected themselves from sunlight less than others believed that their protection level was adequate. Health concerns related to sun exposure suggest the need for increasing the student's awareness in sun protection area. As behavior is influenced by cultural aspects, implementation of the current guideline can be effective in reducing the health effects of sun exposure. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
40. Skin cancer in children after organ transplantation.
- Author
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Imko-Walczuk, Beata, Roskosz-Stożkowska, Magdalena, Szymańska, Katarzyna, Kadylak, Damian, and Dębska-Ślizień, Alicja
- Subjects
- *
RISK factors of skin cancer , *TRANSPLANTATION of organs, tissues, etc. in children , *IMMUNOSUPPRESSION , *CHILDHOOD cancer , *CANCER prevention , *EARLY detection of cancer - Abstract
Skin cancer is the second most common complication of organ transplantation in children. The frequency of skin cancer incidence after organ transplantation is different in paediatric and adult populations. The post-transplant lymphoproliferative disease is the most common group of malignancies after organ transplantation in paediatric population. The majority of researchers who examined children with kidney, liver, heart or lungs grafts observed that the risk of skin cancer was three times higher than in the general population whereas in adults even 200 times higher. The occurrence of skin cancer in children after transplantation is extremely rare during childhood. The risk increases in early adulthood. Malignancies occurring after solid organ transplantation result from many different factors. These include the immunological condition of the child, dose and time of immunosuppression, and oncogenic viruses. The increased risk of skin cancer following paediatric transplantation requires prevention and adequate education of children and their parents. These involve avoiding sun exposure and protection such as sunscreens and protective clothing. The early detection of cancer in transplant recipients is very important. Prevention of cancer includes regular dermatological examination. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
41. Top 10 risk factors of skin cancer
- Subjects
Cancer genetics -- Genetic aspects -- Risk factors -- Health aspects ,Disease susceptibility -- Genetic aspects -- Risk factors -- Health aspects ,Skin cancer -- Genetic aspects -- Risk factors -- Health aspects ,Squamous cell carcinoma -- Genetic aspects -- Risk factors -- Health aspects ,Radiation (Physics) -- Health aspects ,Science and technology - Abstract
Byline: Mansi Kohli Usually caused by mutations in the DNA of the skin cells, skin cancer takes three forms - basal cell carcinoma, squamous cell carcinoma and melanoma. The mutations [...]
- Published
- 2018
42. Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study
- Author
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C. Apap, S. Majewski, Annamari Ranki, Lara Ferrándiz, R. Micallef, Olli Saksela, E.G.E. de Vries, Martina Ulrich, B. Hinrichs, Myrto Trakatelli, Sari Pitkänen, David Moreno-Ramírez, Chiara Fiorentini, Dimitrios Kalabalikis, Eggert Stockfleth, L. Scerri, Demetris Ioannides, Cristina Magnoni, Efthymios Altsitsiadis, Dimitrios Sotiriadis, Charlotte M. Proby, S. Aquilina, and A. Ruiz-de-Casas
- Subjects
medicine.medical_specialty ,business.industry ,Melanoma ,Case-control study ,Dermatology ,Odds ratio ,medicine.disease ,Logistic regression ,Surgery ,Internal medicine ,medicine ,Carcinoma ,Basal cell carcinoma ,Cancer development ,Skin cancer ,business - Abstract
Summary Background During recent years numerous studies have suggested that personal and environmental factors might influence cancer development. Objectives To investigate environmental and personal characteristics associated with skin cancer risk. Methods A multicentre hospital-based case–control study was performed in Finland, Germany, Greece, Italy, Malta, Poland, Scotland and Spain, including 409 patients with squamous cell carcinoma (SCC), 602 with basal cell carcinoma (BCC) and 360 with cutaneous malignant melanoma (CMM) and 1550 control persons. Exposures were assessed by questionnaires that were partly self-administered, partly completed by dermatologists. Unconditional logistic regression modelling was used to assess associations including the influence of certain drugs and food items on skin cancer risk. Results The usual associations were observed for sun exposure and pigmentation characteristics, with chronic sun exposure being most strongly associated with SCC risk, and naevi and atypical naevi with CMM risk. Use of ciprofloxacin was associated with a decreased risk of BCC [odds ratio (OR) 0·33] and use of thiazide diuretics was associated with an increased risk of SCC (OR 1·66). Ciprofloxacin was also associated with SCC (OR 0·34) and thiazines with BCC (OR 2·04), but these associations lost significance after correction for multiple testing. Consumption of pomegranate, rich in antioxidants, was associated with decreased BCC and SCC risk, also after correcting for multiple testing. Recent experience of stressful events was associated with increased risk, particularly of CMM. Conclusions In this large case–control study from across Europe the expected associations were observed for known risk factors. Some new potential protective factors and potential risk factors were identified for consumption of certain food items, medication use and stress, which deserve further investigation in future studies.
- Published
- 2012
43. Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can)
- Author
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Hanno Ulmer, Michael Edlinger, Göran Hallmans, Håkan Jonsson, Jonas Manjer, Christel Häggström, A. Kleiner, Randi Selmer, Anders Engeland, Pär Stattin, Dorthe Johansen, Tanja Stocks, Steinar Tretli, Gabriele Nagel, Tone Bjørge, A Lukanova, and Hans Concin
- Subjects
Oncology ,medicine.medical_specialty ,integumentary system ,business.industry ,Incidence (epidemiology) ,Melanoma ,Case-control study ,MEDLINE ,Cancer ,Dermatology ,medicine.disease ,Internal medicine ,medicine ,Metabolic syndrome ,Skin cancer ,business ,Prospective cohort study - Abstract
Background Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC). Objectives To assess the associations between metabolic ...
- Published
- 2012
44. Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study
- Subjects
SDG 3 - Good Health and Well-being - Abstract
Background During recent years numerous studies have suggested that personal and environmental factors might influence cancer development. Objectives To investigate environmental and personal characteristics associated with skin cancer risk. Methods A multicentre hospital-based casecontrol study was performed in Finland, Germany, Greece, Italy, Malta, Poland, Scotland and Spain, including 409 patients with squamous cell carcinoma (SCC), 602 with basal cell carcinoma (BCC) and 360 with cutaneous malignant melanoma (CMM) and 1550 control persons. Exposures were assessed by questionnaires that were partly self-administered, partly completed by dermatologists. Unconditional logistic regression modelling was used to assess associations including the influence of certain drugs and food items on skin cancer risk. Results The usual associations were observed for sun exposure and pigmentation characteristics, with chronic sun exposure being most strongly associated with SCC risk, and naevi and atypical naevi with CMM risk. Use of ciprofloxacin was associated with a decreased risk of BCC [odds ratio (OR) 0.33] and use of thiazide diuretics was associated with an increased risk of SCC (OR 1.66). Ciprofloxacin was also associated with SCC (OR 0.34) and thiazines with BCC (OR 2.04), but these associations lost significance after correction for multiple testing. Consumption of pomegranate, rich in antioxidants, was associated with decreased BCC and SCC risk, also after correcting for multiple testing. Recent experience of stressful events was associated with increased risk, particularly of CMM. Conclusions In this large casecontrol study from across Europe the expected associations were observed for known risk factors. Some new potential protective factors and potential risk factors were identified for consumption of certain food items, medication use and stress, which deserve further investigation in future studies.
- Published
- 2012
45. Prevalence And Risk Factors Of Skin Cancer In Mexico: An Observational Study
- Author
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G Berdeaux and A Zkik
- Subjects
business.industry ,Environmental health ,Health Policy ,medicine ,Public Health, Environmental and Occupational Health ,Observational study ,Skin cancer ,medicine.disease ,business - Published
- 2015
- Full Text
- View/download PDF
46. Incidence of and risk factors for skin cancer after heart transplant
- Author
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Walter K. Kremers, Randall K. Roenigk, M. Amanda Jacobs, Diederik van de Beek, Clark C. Otley, Ross A. Dierkhising, Oscar R. Colegio, Christopher G.A. McGregor, Jerry D. Brewer, P. Kim Phillips, AII - Amsterdam institute for Infection and Immunity, ANS - Amsterdam Neuroscience, and Neurology
- Subjects
Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,medicine.medical_treatment ,Dermatology ,Article ,Cohort Studies ,Young Adult ,Postoperative Complications ,Risk Factors ,Internal medicine ,medicine ,Humans ,Cumulative incidence ,Basal cell carcinoma ,Risk factor ,Child ,Aged ,Retrospective Studies ,Heart transplantation ,integumentary system ,business.industry ,Incidence ,Incidence (epidemiology) ,Infant ,Cancer ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Tumor Burden ,Surgery ,Carcinoma, Basal Cell ,Child, Preschool ,Carcinoma, Squamous Cell ,Heart Transplantation ,Female ,Skin cancer ,business - Abstract
Objective To examine the incidence, tumor burden, and risk factors for nonmelanoma and other skin cancer types in this heart transplant cohort. Design Retrospective review of patient medical records. Setting Tertiary care center. Patients All heart transplant recipients at Mayo Clinic from 1988 to 2006. Main Outcome Measures Cumulative incidence of skin cancer and tumor burden, with Cox proportional hazards regression models used to evaluate risk factors for posttransplant primary and secondary nonmelanoma skin cancer. Results In total, 312 heart transplant patients had 1395 new skin cancers in 2097 person-years (mean, 0.43 per year per patient) with a range of 0 to 306 for squamous cell carcinoma (SCC) and 0 to 17 for basal cell carcinoma (BCC). The cumulative incidence rates of any skin cancer were 20.4%, 37.5%, and 46.4% at 5, 10, and 15 years after heart transplant, respectively. Cumulative incidence of SCC after the first BCC was 98.1% within 7 years. Multivariate analysis showed that posttransplant nonskin cancer, increased age, and heart failure etiologic factors other than idiopathic disease were associated with increased risk of SCC. Posttransplant herpes simplex viral infection, increased age, and use of mycophenolate mofetil for immunosuppression were associated with increased risk of BCC. Conclusions With prolonged survival, many heart transplant patients have numerous skin cancers. Vigilant sun protection practices, skin cancer education, and regular skin examination are appropriate interventions in these high-risk patients.
- Published
- 2009
47. Prevalence And Risk Factors Of Skin Cancer In Mexico: An Observational Study
- Author
-
Zkik, A, primary and Berdeaux, G, additional
- Published
- 2015
- Full Text
- View/download PDF
48. Prevalence and predictors of sunburn among beachgoers.
- Author
-
de Troya‐Martín, Magdalena, de Gálvez‐Aranda, María Victoria, Rivas‐Ruiz, Francisco, Blázquez‐Sánchez, Nuria, Fernández‐Morano, Maria Teresa, Padilla‐España, Laura, and Herrera‐Ceballos, Enrique
- Subjects
- *
SUNBURN , *RISK factors of skin cancer , *BEACHGOERS , *SUNTAN , *SKIN injuries - Abstract
Summary: Background: Painful sunburns at any age are one of the main risk factors for skin cancer. Objectives: To determine the prevalence and predictors of sunburn among beachgoers. Methods: A cross‐sectional health survey was conducted at the beach during the summer. Adults >18 years with an understanding of Spanish were interviewed using a questionnaire about behaviours, attitudes and knowledge related to sun exposure at the beach. A descriptive analysis was performed, and a log‐binomial regression model was used to determine predictors of sunburn. Results: The survey was completed by 1054 beachgoers, with a mean age of 43.8 (SD: 18.7) years, 61.2% women, skin phototypes i (13.6%), ii (22.3%), iii (34.0%) and iv (30.2%). 46.9% of responders reported at least one painful sunburn during the previous summer. Age, sex, education, skin phototype, midday sun exposure, sun protection habits, attitudes towards tanning and knowledge about skin cancer were identified as independent predictors of sunburn. Conclusions: It is necessary to develop photoprotection campaigns aimed at beachgoers, particularly in young people, men, those with skin phototypes I‐III and secondary or university education. Educational strategies should be aimed at discouraging sun exposure at midday, changing attitudes towards tanning and improving knowledge about skin cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
49. Incidence and risk factors for skin cancer following lung transplantation
- Author
-
Shadi Rashtak, Steve G. Peters, Ross A. Dierkhising, Stephen D. Cassivi, Clark C. Otley, and Walter K. Kremers
- Subjects
Oncology ,Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,medicine.medical_treatment ,Dermatology ,Young Adult ,Postoperative Complications ,Risk Factors ,Internal medicine ,medicine ,Lung transplantation ,Humans ,Basal cell carcinoma ,Cumulative incidence ,Aged ,Retrospective Studies ,integumentary system ,business.industry ,Incidence (epidemiology) ,Incidence ,Cancer ,Immunosuppression ,Middle Aged ,medicine.disease ,Tumor Burden ,Transplantation ,surgical procedures, operative ,Carcinoma, Basal Cell ,Carcinoma, Squamous Cell ,Female ,Skin cancer ,business ,Lung Transplantation - Abstract
Background Relative to other solid-organ transplantations, limited studies characterize skin cancer among lung-transplant recipients. Objective We sought to assess the cumulative incidence, tumor burden, and risk factors for skin cancer among patients with lung transplantation. Methods Medical records of patients at Mayo Clinic who had undergone lung transplantation between 1990 and 2011 were reviewed (N = 166). Results At 5 and 10 years posttransplantation the cumulative incidence was 31% and 47% for any skin cancer, 28% and 42% for squamous cell carcinoma, 12% and 21% for basal cell carcinoma, and 53% and 86% for death, respectively. Four patients died of metastatic squamous cell carcinoma. The cumulative incidence for a subsequent skin cancer of the same type 4 years after an initial skin cancer was 85% and 43% for squamous and basal cell carcinoma, respectively. Increasing age, male gender, skin cancer history, and more recent year of transplantation were associated with increased risk of skin cancer posttransplantation. Sirolimus was not associated with decreased risk, nor did voriconazole show an increased risk for skin cancer. Limitations Retrospective and tertiary single-center design of the study is a limitation. Conclusions Skin cancers frequently occur in lung-transplant recipients. The risk of subsequent skin cancer is increased substantially in patients who develop a skin cancer after their transplantation.
- Published
- 2014
50. Long-term ultraviolet flux, other potential risk factors, and skin cancer risk: a cohort study.
- Author
-
Wu S, Han J, Laden F, and Qureshi AA
- Subjects
- Adult, Cohort Studies, Female, Humans, Male, Risk Factors, Skin Neoplasms etiology, Ultraviolet Rays adverse effects
- Abstract
Background: Few prospective studies have examined the relationship between sun exposure, other potential risk factors, and risk of different skin cancers [including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma] simultaneously., Methods: We evaluated the association between a number of potential risk factors and skin cancer risk in a cohort of 108,916 US women, the Nurses' Health Study II (1989-2009)., Results: During 2.05 million years of follow-up, we identified 6,955, 880, and 779 diagnoses of BCC, SCC, and melanoma, respectively. Compared with participants in the lowest quintile of cumulative ultraviolet flux in adulthood, participants in the highest quintile had multivariable-adjusted relative risks (RR) of 2.35 (Ptrend < 0.0001) for BCC, 2.53 (Ptrend = 0.009) for SCC, and 0.68 (Ptrend = 0.38) for melanoma. In contrast, the RRs were 1.68 (95% CI, 1.55-1.82) for BCC, 1.68 (95% CI, 1.34-2.11) for SCC, and 1.80 (95% CI, 1.42-2.28) for melanoma for participants with ≥5 blistering sunburns when compared with participants without sunburn between ages 15 and 20 years. We found significant interactions between family history of melanoma, number of blistering sunburns between ages 15 and 20 years and BCC risk, and between sunburn reaction as a child/adolescent and SCC risk (all Pinteraction < 0.05)., Conclusion: In a cohort of U.S. women, we found that sun exposures in both early life and adulthood were predictive of BCC and SCC risks, whereas melanoma risk was predominantly associated with sun exposure in early life., Impact: Our results may have potential implications for the prevention of skin cancers. Cancer Epidemiol Biomarkers Prev; 23(6); 1080-9. ©2014 AACR., (©2014 American Association for Cancer Research.)
- Published
- 2014
- Full Text
- View/download PDF
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