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Behavioral Correlates of Maternal Antibody Status among Children with Autism
Behavioral Correlates of Maternal Antibody Status among Children with Autism
- Source :
-
Journal of Autism and Developmental Disorders . Jul 2012 42(7):1435-1445. - Publication Year :
- 2012
-
Abstract
- Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.
Details
- Language :
- English
- ISSN :
- 0162-3257
- Volume :
- 42
- Issue :
- 7
- Database :
- ERIC
- Journal :
- Journal of Autism and Developmental Disorders
- Publication Type :
- Academic Journal
- Accession number :
- EJ969997
- Document Type :
- Journal Articles<br />Reports - Research
- Full Text :
- https://doi.org/10.1007/s10803-011-1378-7