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Behavioral Correlates of Maternal Antibody Status among Children with Autism

Behavioral Correlates of Maternal Antibody Status among Children with Autism

Authors :
Braunschweig, Daniel
Duncanson, Paul
Boyce, Robert
Hansen, Robin
Ashwood, Paul
Pessah, Isaac N.
Hertz-Picciotto, Irva
Van de Water, Judy
Source :
Journal of Autism and Developmental Disorders. Jul 2012 42(7):1435-1445.
Publication Year :
2012

Abstract

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.

Details

Language :
English
ISSN :
0162-3257
Volume :
42
Issue :
7
Database :
ERIC
Journal :
Journal of Autism and Developmental Disorders
Publication Type :
Academic Journal
Accession number :
EJ969997
Document Type :
Journal Articles<br />Reports - Research
Full Text :
https://doi.org/10.1007/s10803-011-1378-7