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Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome
- Source :
-
Journal of Autism and Developmental Disorders . Feb 2011 41(2):248-253. - Publication Year :
- 2011
-
Abstract
- Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p less than 0.002) and FXS-A (p less than 0.003) groups had impaired PPI. The FXS+A (p less than 0.01) and FXS-A (p less than 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating. (Contains 3 tables and 4 figures.)
Details
- Language :
- English
- ISSN :
- 0162-3257
- Volume :
- 41
- Issue :
- 2
- Database :
- ERIC
- Journal :
- Journal of Autism and Developmental Disorders
- Publication Type :
- Academic Journal
- Accession number :
- EJ912249
- Document Type :
- Journal Articles<br />Reports - Research
- Full Text :
- https://doi.org/10.1007/s10803-010-1040-9