Back to Search
Start Over
COMT Val[superscript 108/158] Met Gene Variant, Birth Weight, and Conduct Disorder in Children with ADHD
- Source :
-
Journal of the American Academy of Child and Adolescent Psychiatry . Nov 2006 45(11):1363-1369. - Publication Year :
- 2006
-
Abstract
- Objective: In a recent study, Thapar and colleagues reported that COMT "gene variant and birth weight predict early-onset antisocial behavior in children" with attention-deficit/hyperactivity disorder. We have attempted to replicate these findings in a group of ADHD children using a similar research design. Method: Children (n = 191) between 6 and 12 years of age who were diagnosed with ADHD were included in the study. Conduct disorder was diagnosed according to DSM-IV criteria based on clinical evaluation and a structured interview (Diagnostic Interview Schedule for Children-IV). The mother's report on the child's birth weight was used in the analysis. Logistic regression analysis, with genotype and birth weight as independent variables and DSM-IV conduct disorder as the dependent variable, was conducted. Results: No significant main effects of genotype and birth weight or interaction effects on conduct disorder were observed. Conclusion: In this sample of children diagnosed with ADHD, we find no association between the COMT Val[superscript 108/158] Met gene variant, birth weight, and conduct disorder. Further investigations are required before using birth weight and COMT genotype as predictors of conduct disorder in children with attention-deficit/hyperactivity disorder, especially given the societal and legal ramifications of conduct disorder. (Contains 1 figure and 2 tables.)
Details
- Language :
- English
- ISSN :
- 0890-8567
- Volume :
- 45
- Issue :
- 11
- Database :
- ERIC
- Journal :
- Journal of the American Academy of Child and Adolescent Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- EJ754449
- Document Type :
- Journal Articles<br />Reports - Research