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Examining Associations between Prenatal Biomarkers of Oxidative Stress and ASD-Related Outcomes Using Quantile Regression
- Source :
-
Journal of Autism and Developmental Disorders . Aug 2023 53(8):2975-2985. - Publication Year :
- 2023
-
Abstract
- We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile [beta]: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.
Details
- Language :
- English
- ISSN :
- 0162-3257 and 1573-3432
- Volume :
- 53
- Issue :
- 8
- Database :
- ERIC
- Journal :
- Journal of Autism and Developmental Disorders
- Publication Type :
- Academic Journal
- Accession number :
- EJ1382998
- Document Type :
- Journal Articles<br />Reports - Research
- Full Text :
- https://doi.org/10.1007/s10803-022-05625-9