A retrospective analysis of renal allograft function and biopsy-proven rejection episodes according to donor type.

A retrospective analysis of renal allograft function and biopsy-proven rejection episodes according to donor type.Introduction:It is well recognised that donor type can have a significant impact on allograft outcomes. This study evaluates the impact of donor characteristics on rejection and allograft function in a single large centre.Methods:458 patients undergoing renal transplantation between January 2011 and December 2015 were categorised according to donor characteristics (donation after brain death (DBD), donation after circulatory death (DCD) and live donor (LD)). Delayed graft function (DGF) was defined as the need for haemodialysis within a week of transplantation. Rejection episodes were categorised according to the Banff classification. Serum creatinine and tacrolimus levels were measured periodically throughout the study period.Results:60% DCD, 34% DBD and 3% LD transplants were complicated by DGF. The subsequent risk of rejection after delayed graft function was 29%, compared with 17% in those with immediate graft function. Overall 20% DBD, 24% DCD and 18% LD transplant recipients experienced u22651 rejection episode; when combined, recipients of all deceased donor (DD) organs had a non-significant higher incidence of rejection than LD recipients (22% vs 18%, p=0.29).Though there was no significant difference between DBD and DCD graft function at 1 year (162 vs 169.7u00b5mol/L, p=0.48), significantly better function was seen for LD grafts (126.6u00b5mol/L, p=