IMPACT OF PHYSICAL EXERCISE AND MEDITERRANEAN DIET PRIOR TO STROKE ON THE PROGNOSIS OF PATIENTS UNDERGOING ENDOVASCULAR TREATMENT.

Background and Aims:Physical activity (PA) and some dietary patterns like Mediterranean Diet (MeDiet) are associated with a decreased stroke risk but there are limited data on their association with stroke characteristics and prognosis. We aimed to study the association of pre-stroke PA and adherence to MeDiet with different outcome variables in patients with acute ischemic ischemic stroke (IS) treated with endovascular therapyMethods:We included consecutive patients with IS in 12 NORDICTUS (Stroke network of North Spain) hospitals. Inclusion criteria were: MCA and/or TICA occlusion and baseline mRS 0-1. Degree of PA prior to stroke was evaluated with Spanish Short Version of the Minnesota Leisure Time Physical Activity Questionnaire and adherence to the MeDiet with PREDIMED 14-points questionnaire. Clinical, radiological and prognostic variables were prospectively collected by blind investigators.Results:From 1/15/2018 to 10/30/2018, 239 patients were included (mean age 71 years,48% women, median NIHSS 16). Low adherence to MeDiet was associated with atherotrombotic etiology. Daily intake of red wine was associated with a higher probability of complete recanalization (p=0.048). In multivarable analysis, use of olive oil as the principal source of fat was independently associated with mRS u22642 at 3 months, OR 3.2 [1.2-8.7]. Patients with a lower activity level prior to stroke (sedentary) had more frequently cardioembolic stroke and a higher incidence of symptomatic intracranial hemorrhage. No associations were found between PA or MeDiet and collateral grade, final infarct volume or mortality.Conclusions:PA and some MeDiet patterns may act as preconditioning factors improving prognosis after stroke.