Mesenchymal Stem Cell For Diabetes Mellitus Therapy : Meta Analysis Study

ABSTRACTBackgroundThere is general agreement to ensure promising result of mesenchymal stem cell therapy in diabetes, considering the risk and benefit based on evidence.AimsThis meta analysis aimed to evaluate clinical effect of mesenchymal stem cell in diabetes mellitus in both type.MethodsScreening of eligible publication was done independently by authors, in accordance inclusion criterias such as: 1) written in English; 2) participants were being supervised for at least 1 month; 3) compared to standard treatment group; 4) study was published from 2008 and onwards; 5) the paper employed randomized controlled trials method, and; 6) any situation which altered endocrinology status was excluded. All studies were reviewed using critical appraisal for clinical trials made by Centre for Evidence-Based Medicine Oxford University and risk of bias was determined using Cochrane Handbook for Systematic Reviews of Interventions. Selected papers was entered into Review Manager 5.3 and Graph Prism 8. Mean value of HbA1c was compared between before and after treatment, while u226550% decrease of insulin requirement was compared between a control group and the intervention group. Data was analyzed using mean and risk difference with fixed effects model to avoid heterogeneity. Heterogeneity was determined as significant at P