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Biological activity of electrochemically synthesized silver doped polyvinyl alcohol/graphene composite hydrogel discs for biomedical applications

Authors :
Abudabbus, M. M.
Jevremović, Ivana
Janković, Ana
Perić-Grujić, Aleksandra
Matić, I.
Vukašinović-Sekulić, Maja
Hui, David
Rhee, Kyong Yop
Mišković-Stanković, Vesna
Abudabbus, M. M.
Jevremović, Ivana
Janković, Ana
Perić-Grujić, Aleksandra
Matić, I.
Vukašinović-Sekulić, Maja
Hui, David
Rhee, Kyong Yop
Mišković-Stanković, Vesna
Source :
Composites Part B-Engineering
Publication Year :
2016

Abstract

Silver/poly(vinyl alcohol), Ag/PVA, and silver/poly(vinyl alcohol)/graphene, Ag/PVA/Gr, composite hydrogel discs were produced by freezing/thawing, followed by electrochemical reduction of Ag+ ions inside respective matrices, at constant voltage in specially designed electrochemical cell. Raman, FT-IR and FE-SEM characterized interactions between PVA, graphene and silver nanoparticles. Ag/PVA and Ag/PVA/Gr discs classified as non-cytotoxic towards peripheral blood mononuclear cells (PBMC) according to MTT cytotoxicity test, while exhibiting antibacterial activity against Staphylococcus aureus and Escherichia coli. The slow silver release and high remaining silver content of similar to 67-68 wt % after 28 day immersion in simulated body fluid confirmed that both composites can preserve their sterility overtime.

Details

Database :
OAIster
Journal :
Composites Part B-Engineering
Notes :
Composites Part B-Engineering
Publication Type :
Electronic Resource
Accession number :
edsoai.on1479411571
Document Type :
Electronic Resource