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Combining carbon nanotubes and chitosan for the vectorization of methotrexate to lung cancer cells

Authors :
Cirillo, G
Vittorio, O ; https://orcid.org/0000-0002-6610-1889
Kunhardt, D
Valli, E
Voli, F
Farfalla, A
Curcio, M
Spizzirri, UG
Hampel, S
Cirillo, G
Vittorio, O ; https://orcid.org/0000-0002-6610-1889
Kunhardt, D
Valli, E
Voli, F
Farfalla, A
Curcio, M
Spizzirri, UG
Hampel, S
Source :
urn:ISSN:1996-1944; Materials, 12, 18
Publication Year :
2019

Abstract

A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1s signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299.

Details

Database :
OAIster
Journal :
urn:ISSN:1996-1944; Materials, 12, 18
Notes :
application/pdf
Publication Type :
Electronic Resource
Accession number :
edsoai.on1458868269
Document Type :
Electronic Resource