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Protoporphyrin IX Associated with Visible Light for the Treatment of Trichophyton rubrum Causing Onychomycosis - An Updated Review

Authors :
Taliari, Matheus Alexandre Da Silva
Fontes, Andressa Costa
Araujo, Fellipe Genasculi
Pereira, Luis Lênin Vicente
Simonato, Luciana Estevam
Pinto Neto, José Martins
Lozano, André Wilian
Boer, Nilton Cesar Pezati
da Silva, Wagner Rafael
de Aquino, Rafael Guerra
de Arruda, Farid Jamil Silva
Prates, Fábio Zanusso
de Freitas, Noedi Leoni
Taliari, Jean Donizete Silveira
Ramos, Rogério Rodrigo
Taliari, Matheus Alexandre Da Silva
Fontes, Andressa Costa
Araujo, Fellipe Genasculi
Pereira, Luis Lênin Vicente
Simonato, Luciana Estevam
Pinto Neto, José Martins
Lozano, André Wilian
Boer, Nilton Cesar Pezati
da Silva, Wagner Rafael
de Aquino, Rafael Guerra
de Arruda, Farid Jamil Silva
Prates, Fábio Zanusso
de Freitas, Noedi Leoni
Taliari, Jean Donizete Silveira
Ramos, Rogério Rodrigo
Source :
International Journal for Innovation Education and Research; Vol. 10 No. 6 (2022): International Journal for Innovation Education and Research; 84-101; 2411-2933
Publication Year :
2022

Abstract

Systemic medications used during the treatment of onychomycosis caused by Trichophyton rubrum may have relapse, making them costly and insignificant for the patient. Photodynamic therapy (PDT) is an advantageous therapeutic option for disease control, mainly due to the absence of risk of microbial resistance. The action of PDT is combined by three elements: photosensitizer (PS), visible light (VL) and molecular oxygen, leading to the formation of reactive oxygen species (ROS) or singlet oxygen formation (1O2), both ROS (type I mechanism) as 1O2 (type II mechanism) induce damage and death to microbial cells. This research was proposed as a study through a non-systematic review, to investigate the action of PS "Protoporphyrin IX" (Pp IX) associated with visible light on T. rubrum, contemplating clinical and relevant data regarding the treatment of onychomycosis by PDT. PubMed survey was conducted from June 2021 to April 2022. The research strategy included clinical trials, randomized trials, systematic reviews, meta-analyses and reviews in English. Pp IX has affinity for T. rubrum, which is justified by the incorporation of Pp IX into the cell membrane, which led to inhibition by LV irradiation. Thus, the photodynamic process of Pp IX may lead to cell death by type I and II mechanisms. The data found are promising, however, new studies in vitro and in vivo are suggested, since few studies have been found related to the theme.

Details

Database :
OAIster
Journal :
International Journal for Innovation Education and Research; Vol. 10 No. 6 (2022): International Journal for Innovation Education and Research; 84-101; 2411-2933
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1458538116
Document Type :
Electronic Resource