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Lifestyle and incident dementia : A COSMIC individual participant data meta-analysis

Lifestyle and incident dementia : A COSMIC individual participant data meta-analysis

Authors :
Van Asbroeck, Stephanie
Sterner, Therese Rydberg
Deckers, Kay
Van Asbroeck, Stephanie
Sterner, Therese Rydberg
Deckers, Kay
Publication Year :
2024

Abstract

INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1457483784
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1002.alz.13846