Increased Systemic Immune-Inflammation Index Was Associated with Type 2 Diabetic Peripheral Neuropathy: A Cross-Sectional Study in the Chinese Population

Jia Li,1– 5,* Xing Zhang,1– 5,* Yi Zhang,1– 5,* Xiaofang Dan,1– 5 Xian Wu,1– 5 Yuxia Yang,1– 5 Xiping Chen,6 Shengxi Li,7 Yong Xu,1– 5 Qin Wan,1– 5 Pijun Yan1– 5 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, People’s Republic of China; 3Sichuan Clinical Research Center for Nephropathy, Luzhou, People’s Republic of China; 4Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, People’s Republic of China; 5Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, China, Luzhou, People’s Republic of China; 6Clinical medical college, Southwest Medical University, Luzhou, People’s Republic of China; 7Basic Medical College, Southwest Medical University, Luzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pijun Yan, Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China, Tel/Fax +86-830-3165361, Email peter2007110361@126.comBackground: Systemic immune-inflammation index (SII), a novel inflammatory marker, has been demonstrated to be associated with type 2 diabetes mellitus (T2DM) and its vascular complications, however, the relation between SII and diabetic peripheral neuropathy (DPN) has been never reported. We aimed to explore whether SII is associated with DPN in Chinese population.Methods: A cross-sectional study was conducted among 1460 hospitalized patients with T2DM. SII was calculated as the platelet count × neutrophil count/lymphocyte count, and its possible association with DPN was investigated by correlation and multivariate logistic regression analysis, and subgroup analyses.Results: Patients with higher SII quartiles had higher vibration perception threshold and prevalence of DPN