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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women
- Source :
- Genomics vol.112 (2020) nr.2 p.1223-1232 [ISSN 0888-7543]
- Publication Year :
- 2020
-
Abstract
- We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
Details
- Database :
- OAIster
- Journal :
- Genomics vol.112 (2020) nr.2 p.1223-1232 [ISSN 0888-7543]
- Notes :
- DOI: 10.1016/j.ygeno.2019.07.008, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1445821993
- Document Type :
- Electronic Resource