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The preclinical discovery and development of opicapone for the treatment of Parkinson’s disease
- Source :
- Expert Opinion On Drug Discovery; 10.1080/17460441.2020.1767580; Expert Opinion On Drug Discovery. 15 (9): 1-11
- Publication Year :
- 2020
-
Abstract
- © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Opicapone (OPC) is a well-established catechol-O-methyltransferase (COMT) inhibitor that is approved for the treatment of Parkinson’s disease (PD) associated with L-DOPA/L-amino acid decarboxylase inhibitor (DDI) therapy allowing for prolonged activity due to a more continuous supply of L-DOPA in the brain. Thus, OPC decreases fluctuation in L-DOPA plasma levels and favors more constant central dopaminergic receptor stimulation, thus improving PD symptomatology. Areas covered: This review evaluates the preclinical development, pharmacology, pharmacokinetics and safety profile of OPC. Data was extracted from published preclinical and clinical studies published on PUBMED and SCOPUS (Search period: 2000–2019). Clinical and post-marketing data are also evaluated. Expert opinion: OPC is a third generation COMT inhibitor with a novel structure. It has an efficacy and tolerability superior to its predecessors, tolcapone (TOL) and entacapone (ENT). It also provides a safe and simplified drug regimen that allows neurologists to individually adjust the existing daily administration of L-DOPA. OPC is indicated as an adjunctive therapy to L-DOPA/DDI in patients with PD and end-of-dose motor fluctuations who cannot be stabilized on those combinations.
Details
- Database :
- OAIster
- Journal :
- Expert Opinion On Drug Discovery; 10.1080/17460441.2020.1767580; Expert Opinion On Drug Discovery. 15 (9): 1-11
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1443576986
- Document Type :
- Electronic Resource