Back to Search Start Over

Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

Authors :
Baldwin, Helen; https://orcid.org/0000-0002-9507-9019
Radua, Joaquim; https://orcid.org/0000-0003-1240-5438
Antoniades, Mathilde
Haas, Shalaila S; https://orcid.org/0000-0003-1385-1050
Frangou, Sophia; https://orcid.org/0000-0002-3210-6470
Agartz, Ingrid
Allen, Paul
Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568
Atkinson, Kimberley
Bachman, Peter
Baeza, Inmaculada
Bartholomeusz, Cali F
Chee, Michael W L; https://orcid.org/0000-0002-6087-0548
Colibazzi, Tiziano
Cooper, Rebecca E
Corcoran, Cheryl M; https://orcid.org/0000-0002-8902-4353
Cropley, Vanessa L; https://orcid.org/0000-0003-0029-1525
Ebdrup, Bjørn H; https://orcid.org/0000-0002-2590-5055
Fortea, Adriana
Glenthøj, Louise Birkedal; https://orcid.org/0000-0003-3621-8450
Hamilton, Holly K
Haut, Kristen M
Hayes, Rebecca A
He, Ying
Heekeren, Karsten; https://orcid.org/0000-0001-5105-1922
Kaess, Michael
Kasai, Kiyoto; https://orcid.org/0000-0002-4443-4535
Katagiri, Naoyuki
Kim, Minah; https://orcid.org/0000-0001-8668-0817
Kindler, Jochen
Smigielski, Lukasz; https://orcid.org/0000-0002-7428-7644
et al
ENIGMA Clinical High Risk for Psychosis Working Group
Rössler, Wulf; https://orcid.org/0000-0003-0049-4533
Theodoridou, Anastasia; https://orcid.org/0000-0003-4792-385X
Baldwin, Helen; https://orcid.org/0000-0002-9507-9019
Radua, Joaquim; https://orcid.org/0000-0003-1240-5438
Antoniades, Mathilde
Haas, Shalaila S; https://orcid.org/0000-0003-1385-1050
Frangou, Sophia; https://orcid.org/0000-0002-3210-6470
Agartz, Ingrid
Allen, Paul
Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568
Atkinson, Kimberley
Bachman, Peter
Baeza, Inmaculada
Bartholomeusz, Cali F
Chee, Michael W L; https://orcid.org/0000-0002-6087-0548
Colibazzi, Tiziano
Cooper, Rebecca E
Corcoran, Cheryl M; https://orcid.org/0000-0002-8902-4353
Cropley, Vanessa L; https://orcid.org/0000-0003-0029-1525
Ebdrup, Bjørn H; https://orcid.org/0000-0002-2590-5055
Fortea, Adriana
Glenthøj, Louise Birkedal; https://orcid.org/0000-0003-3621-8450
Hamilton, Holly K
Haut, Kristen M
Hayes, Rebecca A
He, Ying
Heekeren, Karsten; https://orcid.org/0000-0001-5105-1922
Kaess, Michael
Kasai, Kiyoto; https://orcid.org/0000-0002-4443-4535
Katagiri, Naoyuki
Kim, Minah; https://orcid.org/0000-0001-8668-0817
Kindler, Jochen
Smigielski, Lukasz; https://orcid.org/0000-0002-7428-7644
et al
ENIGMA Clinical High Risk for Psychosis Working Group
Rössler, Wulf; https://orcid.org/0000-0003-0049-4533
Theodoridou, Anastasia; https://orcid.org/0000-0003-4792-385X
Source :
Baldwin, Helen; Radua, Joaquim; Antoniades, Mathilde; Haas, Shalaila S; Frangou, Sophia; Agartz, Ingrid; Allen, Paul; Andreassen, Ole A; Atkinson, Kimberley; Bachman, Peter; Baeza, Inmaculada; Bartholomeusz, Cali F; Chee, Michael W L; Colibazzi, Tiziano; Cooper, Rebecca E; Corcoran, Cheryl M; Cropley, Vanessa L; Ebdrup, Bjørn H; Fortea, Adriana; Glenthøj, Louise Birkedal; Hamilton, Holly K; Haut, Kristen M; Hayes, Rebecca A; He, Ying; Heekeren, Karsten; Kaess, Michael; Kasai, Kiyoto; Katagiri, Naoyuki; Kim, Minah; Kindler, Jochen; Smigielski, Lukasz; et al; ENIGMA Clinical High Risk for Psychosis Working Group; Rössler, Wulf; Smigielski, Lukasz; Theodoridou, Anastasia (2022). Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis. Translational Psychiatry, 12(1):297.
Publication Year :
2022

Abstract

Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the ‘normativeness’ of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irre

Details

Database :
OAIster
Journal :
Baldwin, Helen; Radua, Joaquim; Antoniades, Mathilde; Haas, Shalaila S; Frangou, Sophia; Agartz, Ingrid; Allen, Paul; Andreassen, Ole A; Atkinson, Kimberley; Bachman, Peter; Baeza, Inmaculada; Bartholomeusz, Cali F; Chee, Michael W L; Colibazzi, Tiziano; Cooper, Rebecca E; Corcoran, Cheryl M; Cropley, Vanessa L; Ebdrup, Bjørn H; Fortea, Adriana; Glenthøj, Louise Birkedal; Hamilton, Holly K; Haut, Kristen M; Hayes, Rebecca A; He, Ying; Heekeren, Karsten; Kaess, Michael; Kasai, Kiyoto; Katagiri, Naoyuki; Kim, Minah; Kindler, Jochen; Smigielski, Lukasz; et al; ENIGMA Clinical High Risk for Psychosis Working Group; Rössler, Wulf; Smigielski, Lukasz; Theodoridou, Anastasia (2022). Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis. Translational Psychiatry, 12(1):297.
Notes :
application/pdf, info:doi/10.5167/uzh-237617, English, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1443054084
Document Type :
Electronic Resource