Back to Search Start Over

Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring

Authors :
Paqué, Pune N; https://orcid.org/0000-0002-4219-3395
Herz, Christopher
Wiedemeier, Daniel B; https://orcid.org/0000-0001-8997-700X
Mitsakakis, Konstantinos; https://orcid.org/0000-0002-3287-9123
Attin, Thomas
Bao, Kai
Belibasakis, Georgios N; https://orcid.org/0000-0002-8164-0653
Hays, John P
Jenzer, Joël S; https://orcid.org/0000-0002-0590-6894
Kaman, Wendy E
Karpíšek, Michal
Körner, Philipp
Peham, Johannes R
Schmidlin, Patrick R; https://orcid.org/0000-0002-1377-0325
Thurnheer, Thomas; https://orcid.org/0000-0002-8615-8209
Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561
Bostanci, Nagihan
Paqué, Pune N; https://orcid.org/0000-0002-4219-3395
Herz, Christopher
Wiedemeier, Daniel B; https://orcid.org/0000-0001-8997-700X
Mitsakakis, Konstantinos; https://orcid.org/0000-0002-3287-9123
Attin, Thomas
Bao, Kai
Belibasakis, Georgios N; https://orcid.org/0000-0002-8164-0653
Hays, John P
Jenzer, Joël S; https://orcid.org/0000-0002-0590-6894
Kaman, Wendy E
Karpíšek, Michal
Körner, Philipp
Peham, Johannes R
Schmidlin, Patrick R; https://orcid.org/0000-0002-1377-0325
Thurnheer, Thomas; https://orcid.org/0000-0002-8615-8209
Wegehaupt, Florian J; https://orcid.org/0000-0002-3972-0561
Bostanci, Nagihan
Source :
Paqué, Pune N; Herz, Christopher; Wiedemeier, Daniel B; Mitsakakis, Konstantinos; Attin, Thomas; Bao, Kai; Belibasakis, Georgios N; Hays, John P; Jenzer, Joël S; Kaman, Wendy E; Karpíšek, Michal; Körner, Philipp; Peham, Johannes R; Schmidlin, Patrick R; Thurnheer, Thomas; Wegehaupt, Florian J; Bostanci, Nagihan (2021). Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring. Journal of Personalized Medicine, 11(3):235.
Publication Year :
2021

Abstract

This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis revealed four biomarkers (IL-4, IL-13, IL-2-RA, and eotaxin/CCL11) to be of high importance for the correct depiction of caries in 37 of 38 patients. The RF model was then used to classify 10 subjects (five caries-/gingivitis-free and five with caries), who were followed over a period of six months. The results were compared to the clinical assessments of dental specialists, revealing a high correlation between the RF prediction and the clinical classification. Due to the superior sensitivity of the RF model, there was a divergence in the prediction of two caries and four caries-/gingivitis-free subjects. These findings suggest IL-4, IL-13, IL-2-RA, and eotaxin/CCL11 as potential salivary biomarkers for identifying noninvasive caries. Furthermore, we suggest a potential association between JAK/STAT signaling and dental caries onset and progression.

Details

Database :
OAIster
Journal :
Paqué, Pune N; Herz, Christopher; Wiedemeier, Daniel B; Mitsakakis, Konstantinos; Attin, Thomas; Bao, Kai; Belibasakis, Georgios N; Hays, John P; Jenzer, Joël S; Kaman, Wendy E; Karpíšek, Michal; Körner, Philipp; Peham, Johannes R; Schmidlin, Patrick R; Thurnheer, Thomas; Wegehaupt, Florian J; Bostanci, Nagihan (2021). Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring. Journal of Personalized Medicine, 11(3):235.
Notes :
application/pdf, info:doi/10.5167/uzh-207448, English, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1443039762
Document Type :
Electronic Resource