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Synergism between remdesivir and ribavirin leads to SARS-CoV-2 extinction in cell culture

Authors :
Ministerio de Ciencia e Innovación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Instituto de Salud Carlos III
Fundació La Marató de TV3
García-Crespo, Carlos
de Ávila, Ana Isabel
Gallego, Isabel
Soria, María Eugenia
Durán-Pastor, Antoni
Somovilla, Pilar
Martínez-González, Brenda
Muñoz-Flores, Javier
Mínguez, Pablo
Salar-Vidal, Llanos
Esteban-Muñoz, Mario
Cañar-Camacho, Elizabeth
Ferrer-Orta, Cristina
Zuñiga, Sonia
Solá Gurpegui, Isabel
Enjuanes, Luis
Esteban, Jaime
Fernández-Roblas, Ricardo
Gadea, Ignacio
Gómez, Jordi
Verdaguer, Núria
Domingo, Esteban
Perales, Celia
Ministerio de Ciencia e Innovación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Instituto de Salud Carlos III
Fundació La Marató de TV3
García-Crespo, Carlos
de Ávila, Ana Isabel
Gallego, Isabel
Soria, María Eugenia
Durán-Pastor, Antoni
Somovilla, Pilar
Martínez-González, Brenda
Muñoz-Flores, Javier
Mínguez, Pablo
Salar-Vidal, Llanos
Esteban-Muñoz, Mario
Cañar-Camacho, Elizabeth
Ferrer-Orta, Cristina
Zuñiga, Sonia
Solá Gurpegui, Isabel
Enjuanes, Luis
Esteban, Jaime
Fernández-Roblas, Ricardo
Gadea, Ignacio
Gómez, Jordi
Verdaguer, Núria
Domingo, Esteban
Perales, Celia
Publication Year :
2024

Abstract

There is a need for effective anti-COVID-19 treatments, mainly for individuals at risk of severe disease such as the elderly and the immunosuppressed. Drug repositioning has proved effective in identifying drugs that can find a new application for the control of coronavirus disease, in particular COVID-19. The purpose of the present study was to find synergistic antiviral combinations for COVID-19 based on lethal mutagenesis.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1442727758
Document Type :
Electronic Resource

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