Type XXVIII collagen

The human and murine type XVVIII collagen structurally resembles collagen type VI. Type XXVIII collagen is mainly located in peripheral nerves surrounding most nonmyelinating glial cells and dorsal root ganglia, but it is also present in skin calvaria, at the nodes of Ranvier, and as a component of the peripheral nervous system nodal gap. Interestingly, type XXVIII collagen is overexpressed in bleomycin-induced lung and in mouse hepatocarcinoma, suggesting it is involved in damage repair processes. Moreover, clinical studies have reported an increase in the formation of type XXVIII collagen in patients with heart failure with preserved ejection fraction and in patients with lung cancer. Type XXVIII collagen has been shown to be located in murine lungs associated with basement membranes, although the expression is not restricted to this membrane. The research on type XXVIII collagen is still emerging.