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Defining remission in childhood-onset lupus:PReS-endorsed consensus definitions by an international task force
- Source :
- Smith , E M D , Aggarwal , A , Ainsworth , J , on behalf of the International cSLE T2T Task Force , Al-Abadi , E , Avcin , T , Bortey , L , Burnham , J , Ciurtin , C , Hedrich , C M , Kamphuis , S , Lambert , L , Levy , D M , Lewandowski , L , Maxwell , N , Morand , E , Özen , S , Pain , C E , Ravelli , A , Saad Magalhaes , C , Pilkington , C , Schonenberg-Meinema , D , Scott , C , Tullus , K , Beresford , M W , Goilav , B , Goss , N , Oni , L & Marks , S D 2024 , ' Defining remission in childhood-onset lupus : PReS-endorsed consensus definitions by an international task force ' , Clinical Immunology , vol. 263 , 110214 .
- Publication Year :
- 2024
-
Abstract
- Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria.Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.
Details
- Database :
- OAIster
- Journal :
- Smith , E M D , Aggarwal , A , Ainsworth , J , on behalf of the International cSLE T2T Task Force , Al-Abadi , E , Avcin , T , Bortey , L , Burnham , J , Ciurtin , C , Hedrich , C M , Kamphuis , S , Lambert , L , Levy , D M , Lewandowski , L , Maxwell , N , Morand , E , Özen , S , Pain , C E , Ravelli , A , Saad Magalhaes , C , Pilkington , C , Schonenberg-Meinema , D , Scott , C , Tullus , K , Beresford , M W , Goilav , B , Goss , N , Oni , L & Marks , S D 2024 , ' Defining remission in childhood-onset lupus : PReS-endorsed consensus definitions by an international task force ' , Clinical Immunology , vol. 263 , 110214 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1434546474
- Document Type :
- Electronic Resource