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Alterations in leukocyte DNA methylome are associated to immunosuppression in severe clinical phenotypes of septic patients

Authors :
European Commission
Instituto de Salud Carlos III
Agència Valenciana de la Innovació
Fundación la Caixa
Ministerio de Ciencia e Innovación (España)
Beltrán-García, Jesús [0000-0002-4292-5509]
Casabó-Vallés, Germán [0009-0007-0184-9064]
Osca-Verdegal, Rebeca [0000-0002-0562-5945]
Navarrete-López, Paula [0000-0002-7093-2191]
Rodriguez-Gimillo, María [0000-0003-3766-1948]
Nacher-Sendra, Elena [0000-0002-5929-0431
Ferrando-Sánchez, Carolina [0000-0003-4951-0733]
García-López, Eva [0000-0003-1086-3056]
Pallardó, Federico V. [0000-0003-3715-1980]
Carbonell, Nieves [0000-0002-9149-0310]
Mena-Mollá, Salvador [0000-0002-6423-4741]
García-Giménez, José Luis [0000-0001-7547-7872]
Beltrán-García, Jesús
Casabó-Vallés, Germán
Osca-Verdegal, Rebeca
Navarrete-López, Paula
Rodriguez-Gimillo, María
Nacher-Sendra, Elena
Ferrando-Sánchez, Carolina
García-López, Eva
Pallardó, Federico V.
Carbonell, Nieves
Mena-Mollá, Salvador
García-Giménez, José Luis
European Commission
Instituto de Salud Carlos III
Agència Valenciana de la Innovació
Fundación la Caixa
Ministerio de Ciencia e Innovación (España)
Beltrán-García, Jesús [0000-0002-4292-5509]
Casabó-Vallés, Germán [0009-0007-0184-9064]
Osca-Verdegal, Rebeca [0000-0002-0562-5945]
Navarrete-López, Paula [0000-0002-7093-2191]
Rodriguez-Gimillo, María [0000-0003-3766-1948]
Nacher-Sendra, Elena [0000-0002-5929-0431
Ferrando-Sánchez, Carolina [0000-0003-4951-0733]
García-López, Eva [0000-0003-1086-3056]
Pallardó, Federico V. [0000-0003-3715-1980]
Carbonell, Nieves [0000-0002-9149-0310]
Mena-Mollá, Salvador [0000-0002-6423-4741]
García-Giménez, José Luis [0000-0001-7547-7872]
Beltrán-García, Jesús
Casabó-Vallés, Germán
Osca-Verdegal, Rebeca
Navarrete-López, Paula
Rodriguez-Gimillo, María
Nacher-Sendra, Elena
Ferrando-Sánchez, Carolina
García-López, Eva
Pallardó, Federico V.
Carbonell, Nieves
Mena-Mollá, Salvador
García-Giménez, José Luis
Publication Year :
2023

Abstract

Sepsis patients experience a complex interplay of host pro- and anti-inflammatory processes which compromise the clinical outcome. Despite considering the latest clinical and scientific research, our comprehension of the immunosuppressive events in septic episodes remains incomplete. Additionally, a lack of data exists regarding the role of epigenetics in modulating immunosuppression, subsequently impacting patient survival.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1431964141
Document Type :
Electronic Resource