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Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood:Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits
- Source :
- Verhoef , E , Allegrini , A G , Jansen , P R , EAGLE Working Group , Lange , K , Wang , C A , Morgan , A T , Ahluwalia , T S , Symeonides , C , Andreassen , O A , Bartels , M , Boomsma , D , Dale , P S , Ehli , E , Fernandez-Orth , D , Guxens , M , Hakulinen , C , Harris , K M , Haworth , S , de Hoyos , L , Jaddoe , V , Keltikangas-Järvinen , L , Lehtimäki , T , Middeldorp , C , Min , J L , Mishra , P P , Njølstad , P R , Sunyer , J , Tate , A E , Timpson , N , van der Laan , C , Vrijheid , M , Vuoksimaa , E , Whipp , A , Ystrom , E , ACTION Consortium , C , Barwon Infant Study investigator group , I S I G , Eising , E , Franken , M C , Hypponen , E , Mansell , T , Olislagers , M , Omerovic , E , Rimfeld , K , Schlag , F , Selzam , S , Shapland , C Y , Tiemeier , H , Whitehouse , A J O , Saffery , R & Cecil , C A M 2024 , ' Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood : Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits ' , Biological Psychiatry , vol. 95 , no. 9 , pp. 859-869 .
- Publication Year :
- 2024
-
Abstract
- Background: The number of words children produce (expressive vocabulary) and understand (receptive vocabulary) changes rapidly during early development, partially due to genetic factors. Here, we performed a meta–genome-wide association study of vocabulary acquisition and investigated polygenic overlap with literacy, cognition, developmental phenotypes, and neurodevelopmental conditions, including attention-deficit/hyperactivity disorder (ADHD). Methods: We studied 37,913 parent-reported vocabulary size measures (English, Dutch, Danish) for 17,298 children of European descent. Meta-analyses were performed for early-phase expressive (infancy, 15–18 months), late-phase expressive (toddlerhood, 24–38 months), and late-phase receptive (toddlerhood, 24–38 months) vocabulary. Subsequently, we estimated single nucleotide polymorphism–based heritability (SNP-h2) and genetic correlations (rg) and modeled underlying factor structures with multivariate models. Results: Early-life vocabulary size was modestly heritable (SNP-h2 = 0.08–0.24). Genetic overlap between infant expressive and toddler receptive vocabulary was negligible (rg = 0.07), although each measure was moderately related to toddler expressive vocabulary (rg = 0.69 and rg = 0.67, respectively), suggesting a multifactorial genetic architecture. Both infant and toddler expressive vocabulary were genetically linked to literacy (e.g., spelling: rg = 0.58 and rg = 0.79, respectively), underlining genetic similarity. However, a genetic association of early-life vocabulary with educational attainment and intelligence emerged only during toddlerhood (e.g., receptive vocabulary and intelligence: rg = 0.36). Increased ADHD risk was genetically associated with larger infant expressive vocabulary (rg = 0.23). Multivariate genetic models in the ALSPAC (Avon Longitudinal Study of Parents and Children) cohort confirme
Details
- Database :
- OAIster
- Journal :
- Verhoef , E , Allegrini , A G , Jansen , P R , EAGLE Working Group , Lange , K , Wang , C A , Morgan , A T , Ahluwalia , T S , Symeonides , C , Andreassen , O A , Bartels , M , Boomsma , D , Dale , P S , Ehli , E , Fernandez-Orth , D , Guxens , M , Hakulinen , C , Harris , K M , Haworth , S , de Hoyos , L , Jaddoe , V , Keltikangas-Järvinen , L , Lehtimäki , T , Middeldorp , C , Min , J L , Mishra , P P , Njølstad , P R , Sunyer , J , Tate , A E , Timpson , N , van der Laan , C , Vrijheid , M , Vuoksimaa , E , Whipp , A , Ystrom , E , ACTION Consortium , C , Barwon Infant Study investigator group , I S I G , Eising , E , Franken , M C , Hypponen , E , Mansell , T , Olislagers , M , Omerovic , E , Rimfeld , K , Schlag , F , Selzam , S , Shapland , C Y , Tiemeier , H , Whitehouse , A J O , Saffery , R & Cecil , C A M 2024 , ' Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood : Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits ' , Biological Psychiatry , vol. 95 , no. 9 , pp. 859-869 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1430692922
- Document Type :
- Electronic Resource