Fueling the cell division cycle

Salazar-Roa, Maria as first author. M.S.R. thanks the Asociación Española contra el Cáncer (AECC) for support. Research in the laboratory of the authors is supported by grants from the Comunidad de Madrid (S2010/BMD-2470), Spanish Ministry of Economy and Competitiveness (BFU2014-52125-REDT, SAF2014-57791-REDC, PCIN-2015-007 and SAF2015-69920-R cofunded by ERDF-EU), Worldwide Cancer Research (WCR no. 15-0278), and the European Commission Seventh Framework Programme (MitoSys project HEALTH-F5-2010-241548 and NEURON8-Full-815-094).
Cell division is a complex process with high energy demands. However, how cells regulate the generation of energy required for DNA synthesis and chromosome segregation is not well understood. Recent data suggest that changes in mitochondrial dynamics and metabolic pathways such as oxidative phosphorylation (OXPHOS) and glycolysis crosstalk with, and are tightly regulated by, the cell division machinery. Alterations in energy availability trigger cell-cycle checkpoints, suggesting a bidirectional connection between cell division and general metabolism. Some of these connections are altered in human disease, and their manipulation may help in designing therapeutic strategies for specific diseases including cancer. We review here recent studies describing the control of metabolism by the cell-cycle machinery.
Depto. de Bioquímica y Biología Molecular
Fac. de Ciencias Biológicas
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