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Solid Implantable Devices for Sustained Drug Delivery

Authors :
Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica
Academy of Medical Sciences
Engineering and Physical Sciences Research Council (UK)
European Union (UE). H2020
Ministerio de Ciencia e Innovación (MICIN). España
Magill, Elizabeth
Demartis, Sara
Gavini, Elisabetta
Permana, Andi Dian
Thakur, Raghu Raj Singh
Adrianto, Muhammad Faris
Waite, David
Glover, Katie
Picco, Camila J.
Korelidou, Anna
Domínguez Robles, Juan
Larrañeta, Eneko
Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica
Academy of Medical Sciences
Engineering and Physical Sciences Research Council (UK)
European Union (UE). H2020
Ministerio de Ciencia e Innovación (MICIN). España
Magill, Elizabeth
Demartis, Sara
Gavini, Elisabetta
Permana, Andi Dian
Thakur, Raghu Raj Singh
Adrianto, Muhammad Faris
Waite, David
Glover, Katie
Picco, Camila J.
Korelidou, Anna
Domínguez Robles, Juan
Larrañeta, Eneko
Publication Year :
2023

Abstract

Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes. Oral and injectable drug administration are the most common routes for drug delivery providing peaks of drug concentrations in blood after administration followed by concentration decay after a few hours. Therefore, constant drug administration is required to keep drug levels within the therapeutic window of the drug. Moreover, oral drug delivery presents alternative challenges due to drug degradation within the gastrointestinal tract or first pass metabolism. IDDS can be used to provide sustained drug delivery for prolonged periods of time. The use of this type of systems is especially interesting for the treatment of chronic conditions where patient adherence to conventional treatments can be challenging. These systems are normally used for systemic drug delivery. However, IDDS can be used for localised administration to maximise the amount of drug delivered within the active site while reducing systemic exposure. This review will cover current applications of IDDS focusing on the materials used to prepare this type of systems and the main therapeutic areas of application.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1428005101
Document Type :
Electronic Resource