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Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light

Authors :
Zmejkoski, Danica
Zdravković, Nemanja M.
Budimir Filimonović, Milica D.
Pavlović, Vladimir B.
Butulija, Svetlana
Milivojević, Dušan
Marković, Zoran M.
Todorović Marković, Biljana
Zmejkoski, Danica
Zdravković, Nemanja M.
Budimir Filimonović, Milica D.
Pavlović, Vladimir B.
Butulija, Svetlana
Milivojević, Dušan
Marković, Zoran M.
Todorović Marković, Biljana
Source :
Journal of Functional Biomaterials
Publication Year :
2024

Abstract

In this study, nanochitosan dots (ChiDs) were synthesized using gamma rays and encapsulated in bacterial cellulose (BC) polymer matrix for antibiofilm potential in photodynamic therapy. The composites were analyzed for structural changes using SEM, AFM, FTIR, XRD, EPR, and porosity measurements. Additionally, ChiD release was assessed. The results showed that the chemical composition remained unaltered, but ChiD agglomerates embedded in BC changed shape (1.5–2.5 µm). Bacterial cellulose fibers became deformed and interconnected, with increased surface roughness and porosity and decreased crystallinity. No singlet oxygen formation was observed, and the total amount of released ChiD was up to 16.10%. Antibiofilm activity was higher under green light, with reductions ranging from 48 to 57% under blue light and 78 to 85% under green light. Methicillin-resistant Staphylococcus aureus was the most sensitive strain. The new photoactive composite hydrogels show promising potential for combating biofilm-related infections.

Details

Database :
OAIster
Journal :
Journal of Functional Biomaterials
Notes :
Journal of Functional Biomaterials
Publication Type :
Electronic Resource
Accession number :
edsoai.on1427433627
Document Type :
Electronic Resource