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Persistence of candida albicans in the oral mucosa induces a curbed inflammatory host response that is independent of immunosuppression

Authors :
Kirchner, Florian R
Littringer, Katharina
Altmeier, Simon
Tran, Van Du Thuong
Schönherr, Franziska
Lemberg, Christina
Pagni, Marco
Sanglard, Dominique
Joller, Nicole
LeibundGut-Landmann, Salomé; https://orcid.org/0000-0002-5724-4837
Kirchner, Florian R
Littringer, Katharina
Altmeier, Simon
Tran, Van Du Thuong
Schönherr, Franziska
Lemberg, Christina
Pagni, Marco
Sanglard, Dominique
Joller, Nicole
LeibundGut-Landmann, Salomé; https://orcid.org/0000-0002-5724-4837
Source :
Kirchner, Florian R; Littringer, Katharina; Altmeier, Simon; Tran, Van Du Thuong; Schönherr, Franziska; Lemberg, Christina; Pagni, Marco; Sanglard, Dominique; Joller, Nicole; LeibundGut-Landmann, Salomé (2019). Persistence of candida albicans in the oral mucosa induces a curbed inflammatory host response that is independent of immunosuppression. Frontiers in Immunology, 10:330.
Publication Year :
2019

Abstract

Controlled immune activation in response to commensal microbes is critical for the maintenance of stable colonization and prevention of microbial overgrowth on epithelial surfaces. Our understanding of the host mechanisms that regulate bacterial commensalism has increased substantially, however, much less data exist regarding host responses to members of the fungal microbiota on colonized surfaces. Using a murine model of oropharyngeal candidiasis, we have recently shown that differences in immune activation in response to diverse natural isolates of Candida albicans are associated with different outcomes of the host-fungal interaction. Here we applied a genome-wide transcriptomic approach to show that rapid induction of a strong inflammatory response characterized by neutrophil-associated genes upon C. albicans colonization inversely correlated with the ability of the fungus to persist in the oral mucosa. Surprisingly, persistent fungal isolates showed no signs of a compensatory regulatory immune response. By combining RNA-seq data, genetic mouse models, and co-infection experiments, we show that attenuation of the inflammatory response at the onset of infection with a persistent isolate is not a consequence of enhanced immunosuppression. Importantly, depletion of regulatory T cells or deletion of the immunoregulatory cytokine IL-10 did not alter host-protective type 17 immunity nor did it impair fungal survival in the oral mucosa, indicating that persistence of C. albicans in the oral mucosa is not a consequence of suppressed antifungal immunity.

Details

Database :
OAIster
Journal :
Kirchner, Florian R; Littringer, Katharina; Altmeier, Simon; Tran, Van Du Thuong; Schönherr, Franziska; Lemberg, Christina; Pagni, Marco; Sanglard, Dominique; Joller, Nicole; LeibundGut-Landmann, Salomé (2019). Persistence of candida albicans in the oral mucosa induces a curbed inflammatory host response that is independent of immunosuppression. Frontiers in Immunology, 10:330.
Notes :
application/pdf, info:doi/10.5167/uzh-169536, English, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1416173767
Document Type :
Electronic Resource