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Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Authors :
Lannes, Nils
Eppler, Elisabeth; https://orcid.org/0000-0002-8453-8312
Etemad, Samar
Yotovski, Peter
Filgueira, Luis; https://orcid.org/0000-0002-2266-6650
Lannes, Nils
Eppler, Elisabeth; https://orcid.org/0000-0002-8453-8312
Etemad, Samar
Yotovski, Peter
Filgueira, Luis; https://orcid.org/0000-0002-2266-6650
Source :
Lannes, Nils; Eppler, Elisabeth; Etemad, Samar; Yotovski, Peter; Filgueira, Luis (2017). Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system. OncoTarget, 8(69):114393-114413.
Publication Year :
2017

Abstract

Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the pathogenesis of neurodegenerative diseases and contribute to aging. They play an important role in sustaining and breaking the blood-brain barrier. As innate immune cells, they contribute substantially to the immune response against infectious agents affecting the CNS. They play also a major role in the growth of tumours of the CNS. Microglia are consequently the key cell population linking the nervous and the immune system. This review covers all different aspects of microglia biology and pathology in a comprehensive way.

Details

Database :
OAIster
Journal :
Lannes, Nils; Eppler, Elisabeth; Etemad, Samar; Yotovski, Peter; Filgueira, Luis (2017). Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system. OncoTarget, 8(69):114393-114413.
Notes :
application/pdf, info:doi/10.5167/uzh-162813, English, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1416171655
Document Type :
Electronic Resource