Back to Search
Start Over
The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents
- Source :
- ACS Pharmacology & Translational Science 5(2022)11, 1097-1108
- Publication Year :
- 2022
-
Abstract
- The multifactorial nature of Alzheimer’s disease necessitates the development of agents able to interfere with different relevant targets. A series of 22 tailored chromanones was conceptualized, synthesized and subjected to biological evaluation. We identified one representative bearing a linker-connected azepane moiety (compound 19) with balanced pharmacological properties. Compound 19 exhibited inhibitory activities against human acetyl-, butyrylcholinesterase and monoamine oxidase-B, as well as high affinity to both the 1 and 2 receptor. Our study provides a framework for the development of further chromanone-based multineurotarget agents.
Details
- Database :
- OAIster
- Journal :
- ACS Pharmacology & Translational Science 5(2022)11, 1097-1108
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1415626450
- Document Type :
- Electronic Resource