Real-time and online adaptive particle therapy in 10 years: a Delphi consensus analysis

Real-time and online adaptive particle therapy in 10 years: a Delphi consensus analysis P. Trnkova1, Y. Zhang2, T. Toshito3, B. Heijmen4, C. Richter5, M. Aznar6, F. Albertini2, A. Bolsi2, J. Daartz7, A. Knopf2,8, J. Bertholet9 1Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria 2Center for Proton Therapy, Paul Scherrer Institute; Villigen, Switzerland 3Nagoya Proton Therapy Center, Nagoya City University West Medical Center, Nagoya, Japan 4Department of Radiotherapy, Erasmus University Medical Center (Erasmus MC), Rotterdam, the Netherlands 5 OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden – Rossendorf, Dresden, Germany 6 Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom 7Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston MA 02114, United States of America 8 Institute for Medical Engineering and Medical Informatics, School of Life Sciences, University for Applied Sciences and Arts Northwestern Switzerland. 9 Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, Bern, Switzerland Purpose/objectives: To collect experts’ opinion on the future of Online Adaptive Particle Therapy (OAPT) and Real Time Motion Management (RRMM) for a vision with a ten-year horizon. Material/Methods: Following the POP-ART PT survey on current status [1], the present 3-round Delphi consensus study addresses the future of OAPT and RRMM with a panel of 11 experts using questionnaires. Second and third rounds were adapted based on the answers from the previous round to generate controlled opinion feedback (Figure 1). Full consensus (FC) or partial consensus (PC) were reached when all experts agreed or only one expert had a different opinion, respectively. R