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Particle Range Retrieval in Heterogeneous Phantoms with the Prompt Gamma Timing Method at a Clinical Proton Accelerator

Authors :
Hueso-Gonzalez, F.
Golnik, C.
Berthel, M.
Dreyer, A.
Enghardt, W.
Fiedler, F.
Heidel, K.
Janssens, G.
Kormoll, T.
Petzoldt, J.
Prieels, D.
Priegnitz, M.
Roemer, K. E.
Smeets, J.
Sobiella, M.
Vander Stappen, F.
Wagner, A.
Weinberger, D.
Pausch, G.
Hueso-Gonzalez, F.
Golnik, C.
Berthel, M.
Dreyer, A.
Enghardt, W.
Fiedler, F.
Heidel, K.
Janssens, G.
Kormoll, T.
Petzoldt, J.
Prieels, D.
Priegnitz, M.
Roemer, K. E.
Smeets, J.
Sobiella, M.
Vander Stappen, F.
Wagner, A.
Weinberger, D.
Pausch, G.
Source :
2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (2014 NSS/MIC), 08.-15.11.2014, Seattle, USA
Publication Year :
2014

Abstract

The characteristic dose profile of accelerated ions has opened up new horizons in the context of cancer treatment. However, particle range uncertainties strongly constrain the potential of ion beam therapy. Despite of worldwide efforts, a detector system for range and dose delivery assessment in real-time is not yet available for clinical routine. Complementary to the active- and passively collimated prompt gamma ray imaging systems for range assessment under development in several research centers, the prompt gamma ray timing method has been recently proposed. Based on the measurable transit time of ions through matter, the emission times of prompt gamma rays encode essential information about the depth-dose profile. In a collaboration between OncoRay, Helmholtz-Zentrum Dresden-Rossendorf and IBA, the prompt gamma ray timing method was tested for the first time at a clinical proton accelerator (Westdeutsches Protonentherapiezentrum Essen) with different phantoms. Several fast scintillation detectors were used to acquire prompt gamma ray timing distributions at various geometries and proton energies. From the resulting distributions, particle range differences of around 5 millimeters in heterogeneous phantoms were observed. In conclusion, we proved the feasibility of the prompt gamma ray timing method for range verification in a clinical radiation environment and realistic phantoms, which reassures this novel approach as a promising alternative in the field of prompt gamma based in vivo dosimetry.

Details

Database :
OAIster
Journal :
2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (2014 NSS/MIC), 08.-15.11.2014, Seattle, USA
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1415598999
Document Type :
Electronic Resource