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Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function

Authors :
Madsen, Helena B.
Peeters, Marlies JW
Straten, Per thor
Desler, Claus
Madsen, Helena B.
Peeters, Marlies JW
Straten, Per thor
Desler, Claus
Source :
Madsen , H B , Peeters , M JW , Straten , P T & Desler , C 2023 , ' Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function ' , Current Opinion in Biotechnology , vol. 84 , 103008 .
Publication Year :
2023

Abstract

Nucleotide metabolism plays a crucial role in the regulation of the tumor microenvironment (TME) and immune cell function. In the TME, limited availability of nucleotide precursors due to increased consumption by tumor cells and T cells affects both tumor development and immune function. Metabolic reprogramming in tumor cells favors pathways supporting growth and proliferation, including nucleotide synthesis. Additionally, extracellular nucleotides, such as ATP and adenosine, exhibit dual roles in modulating immune function and tumor cell survival. ATP stimulates antitumor immunity by activating purinergic receptors, while adenosine acts as a potent immunosuppressor. Targeting nucleotide metabolism in the TME holds immense promise for cancer therapy. Understanding the intricate relationship between nucleotide metabolism, the TME, and immune responses will pave the way for innovative therapeutic interventions.<br />Nucleotide metabolism plays a crucial role in the regulation of the tumor microenvironment (TME) and immune cell function. In the TME, limited availability of nucleotide precursors due to increased consumption by tumor cells and T cells affects both tumor development and immune function. Metabolic reprogramming in tumor cells favors pathways supporting growth and proliferation, including nucleotide synthesis. Additionally, extracellular nucleotides, such as ATP and adenosine, exhibit dual roles in modulating immune function and tumor cell survival. ATP stimulates antitumor immunity by activating purinergic receptors, while adenosine acts as a potent immunosuppressor. Targeting nucleotide metabolism in the TME holds immense promise for cancer therapy. Understanding the intricate relationship between nucleotide metabolism, the TME, and immune responses will pave the way for innovative therapeutic interventions.

Details

Database :
OAIster
Journal :
Madsen , H B , Peeters , M JW , Straten , P T & Desler , C 2023 , ' Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function ' , Current Opinion in Biotechnology , vol. 84 , 103008 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1414369544
Document Type :
Electronic Resource