Cp*M-Catalyzed Direct Annulation with Terminal Alkynes and Their Surrogates for the Construction of Multi-Ring Systems

Nishii Y., Miura M.. Cp*M-Catalyzed Direct Annulation with Terminal Alkynes and Their Surrogates for the Construction of Multi-Ring Systems. ACS Catalysis. 10(17), 9747-9757, (2020), 4 September 2020; ©2020 American Chemical Society. https://doi.org/10.1021/acscatal.0c02972.
Transition-metal-catalyzed C–H activation followed by oxidative cyclization with unsaturated coupling partners has been a valuable synthetic tool for the multi-ring molecular scaffolds. This Perspective introduces the recent progress on the Cp*M-catalyzed (M = Co, Rh, and Ir) oxidative direct annulation of functionalized arenes with terminal alkynes and their equivalents through C–H bond cleavage. The highlighted examples are categorized according to the ten different types of reagents used in the transfor-mations. The representative conditions, selected examples of the reaction scope, and key mechanistic aspects are briefly summarized.