Efficacy of Psychosocial and Psychological Interventions in Addition to Drug Therapy to Improve Global Functioning of Inpatients with Schizophrenia Spectrum and Mood Disorders: A Real-World Observational Study

Stefania Chiappini,1,2 Francesco Di Carlo,1 Alessio Mosca,1 Giacomo d’Andrea,1 Mariapia Di Paolo,1 Chiara Lorenzini,1 Maria Grazia Lupica,1 Gaia Sampogna,3 Mauro Pettorruso,1 Andrea Fiorillo,3 Giovanni Martinotti1,2 1Department of Neurosciences, Imaging and Clinical Sciences, ‘G. D’Annunzio’ University, Chieti, Italy; 2Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK; 3Department of Psychiatry, University of Campania “L. Vanvitelli”, Naples, ItalyCorrespondence: Stefania Chiappini, Department of Neurosciences, Imaging and Clinical Sciences, ‘G. D’Annunzio’ University, via dei Vestini, 31, Chieti (CH), 66100, Italy, Tel +393331698033, Email stefaniachiappini9@gmail.comIntroduction and Aim: Psychotic and mood disorders are associated with significant functional impairment, premature mortality, physical morbidity, and great social and economic burden. The aim of this study is to evaluate the effectiveness of psychosocial, psychological, and rehabilitative interventions implemented in an Italian psychiatric inpatient facility, with a focus on patients with schizophrenia spectrum versus those with mood disorders.Methods: A retrospective observational study was conducted in the psychiatric hospital Villa Maria Pia in Rome, Italy, during 2022. Patients with an established diagnosis of schizophrenia spectrum and mood disorder (ICD-9-CM) were assessed on admission (T0) and at the end of treatment (T1), using the Brief Psychiatric Rating Scale (BPRS) and the Global Assessment of Functioning (GAF). Interventions involved a multidisciplinary team and included individual and group activities. The t-test for independent samples was used to compare continuous variables between groups and Spearman correlation coefficient to calculate correlations between variables.Results: The study sample consisted of 141 patients, the majority of them being adults (51.3