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Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis

Authors :
Hoogman, Martine
Bralten, Janita
Hibar, Derrek P.
Mennes, Maarten
Zwiers, Marcel P.
Schweren, Lizanne S.J.
van Hulzen, Kimm J.E.
Medland, Sarah E.
Shumskaya, Elena
Jahanshad, Neda
Zeeuw, Patrick de
Szekely, Eszter
Sudre, Gustavo
Wolfers, Thomas
Onnink, Alberdingk M.H.
Dammers, Janneke T.
Mostert, Jeanette C.
Vives-Gilabert, Yolanda
Kohls, Gregor
Oberwelland, Eileen
Seitz, Jochen
Schulte-Rüther, Martin
Ambrosino, Sara
Doyle, Alysa E.
Høvik, Marie F.
Dramsdahl, Margaretha
Tamm, Leanne
van Erp, Theo G.M.
Dale, Anders
Schork, Andrew
Conzelmann, Annette
Zierhut, Kathrin
Baur, Ramona
McCarthy, Hazel
Yoncheva, Yuliya N.
Cubillo, Ana
Chantiluke, Kaylita
Mehta, Mitul A.
Paloyelis, Yannis
Hohmann, Sarah
Baumeister, Sarah
Bramati, Ivanei
Mattos, Paulo
Tovar-Moll, Fernanda
Douglas, Pamela
Banaschewski, Tobias
Brandeis, Daniel
Kuntsi, Jonna
Asherson, Philip
Rubia, Katya
Kelly, Clare
Martino, Adriana Di
Milham, Michael P.
Castellanos, Francisco X.
Frodl, Thomas
Zentis, Mariam
Lesch, Klaus Peter
Reif, Andreas
Pauli, Paul
Jernigan, Terry L.
Haavik, Jan
Plessen, Kerstin J.
Lundervold, Astri J.
Hugdahl, Kenneth
Seidman, Larry J.
Biederman, Joseph
Rommelse, Nanda
Heslenfeld, Dirk J.
Hartman, Catharina A.
Hoekstra, Pieter J.
Oosterlaan, Jaap
Polier, Georg von
Konrad, Kerstin
Vilarroya, Oscar
Ramos-Quiroga, Josep Antoni
Soliva, Joan Carles
Durston, Sarah
Buitelaar, Jan K.
Faraone, Stephen V.
Shaw, Philip
Thompson, Paul M.
Franke, Barbara
Hoogman, Martine
Bralten, Janita
Hibar, Derrek P.
Mennes, Maarten
Zwiers, Marcel P.
Schweren, Lizanne S.J.
van Hulzen, Kimm J.E.
Medland, Sarah E.
Shumskaya, Elena
Jahanshad, Neda
Zeeuw, Patrick de
Szekely, Eszter
Sudre, Gustavo
Wolfers, Thomas
Onnink, Alberdingk M.H.
Dammers, Janneke T.
Mostert, Jeanette C.
Vives-Gilabert, Yolanda
Kohls, Gregor
Oberwelland, Eileen
Seitz, Jochen
Schulte-Rüther, Martin
Ambrosino, Sara
Doyle, Alysa E.
Høvik, Marie F.
Dramsdahl, Margaretha
Tamm, Leanne
van Erp, Theo G.M.
Dale, Anders
Schork, Andrew
Conzelmann, Annette
Zierhut, Kathrin
Baur, Ramona
McCarthy, Hazel
Yoncheva, Yuliya N.
Cubillo, Ana
Chantiluke, Kaylita
Mehta, Mitul A.
Paloyelis, Yannis
Hohmann, Sarah
Baumeister, Sarah
Bramati, Ivanei
Mattos, Paulo
Tovar-Moll, Fernanda
Douglas, Pamela
Banaschewski, Tobias
Brandeis, Daniel
Kuntsi, Jonna
Asherson, Philip
Rubia, Katya
Kelly, Clare
Martino, Adriana Di
Milham, Michael P.
Castellanos, Francisco X.
Frodl, Thomas
Zentis, Mariam
Lesch, Klaus Peter
Reif, Andreas
Pauli, Paul
Jernigan, Terry L.
Haavik, Jan
Plessen, Kerstin J.
Lundervold, Astri J.
Hugdahl, Kenneth
Seidman, Larry J.
Biederman, Joseph
Rommelse, Nanda
Heslenfeld, Dirk J.
Hartman, Catharina A.
Hoekstra, Pieter J.
Oosterlaan, Jaap
Polier, Georg von
Konrad, Kerstin
Vilarroya, Oscar
Ramos-Quiroga, Josep Antoni
Soliva, Joan Carles
Durston, Sarah
Buitelaar, Jan K.
Faraone, Stephen V.
Shaw, Philip
Thompson, Paul M.
Franke, Barbara
Source :
Vrije Universiteit Amsterdam Repository
Publication Year :
2017

Abstract

Background Neuroimaging studies have shown structural alterations in several brain regions in children and adults with attention deficit hyperactivity disorder (ADHD). Through the formation of the international ENIGMA ADHD Working Group, we aimed to address weaknesses of previous imaging studies and meta-analyses, namely inadequate sample size and methodological heterogeneity. We aimed to investigate whether there are structural differences in children and adults with ADHD compared with those without this diagnosis. Methods In this cross-sectional mega-analysis, we used the data from the international ENIGMA Working Group collaboration, which in the present analysis was frozen at Feb 8, 2015. Individual sites analysed structural T1-weighted MRI brain scans with harmonised protocols of individuals with ADHD compared with those who do not have this diagnosis. Our primary outcome was to assess case-control differences in subcortical structures and intracranial volume through pooling of all individual data from all cohorts in this collaboration. For this analysis, p values were significant at the false discovery rate corrected threshold of p=0·0156. Findings Our sample comprised 1713 participants with ADHD and 1529 controls from 23 sites with a median age of 14 years (range 4–63 years). The volumes of the accumbens (Cohen's d=−0·15), amygdala (d=−0·19), caudate (d=−0·11), hippocampus (d=−0·11), putamen (d=−0·14), and intracranial volume (d=−0·10) were smaller in individuals with ADHD compared with controls in the mega-analysis. There was no difference in volume size in the pallidum (p=0·95) and thalamus (p=0·39) between people with ADHD and controls. Exploratory lifespan modelling suggested a delay of maturation and a delay of degeneration, as effect sizes were highest in most subgroups of children (<15 years) versus adults (>21 years): in the accumbens (Cohen's d=−0·19 vs −0·10), amygdala (d=−0·18 vs −0·14), caudate (d=−0·13 vs −0·07), hippocampus (d=−0·12 vs

Details

Database :
OAIster
Journal :
Vrije Universiteit Amsterdam Repository
Notes :
The Lancet. Psychiatry vol.4 (2017) nr.4 p.310-319 [ISSN 2215-0366], English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1409138482
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1016.S2215-0366(17)30049-4