Liver Transplantation with Use of Cyclosporin a and Prednisone

THE difficulties in consistently prolonging survival after orthotopic liver transplantation have been documented by us1 and by Calne.2 In this report we describe a new trial of orthotopic liver transplantation in 14 patients who were scheduled to be treated with cyclosporin A and prednisone. Two patients died during the operation. Ten (83 per cent) of the 12 patients who survived surgery and received the drugs are living after eight to 14 1/2 months; another lived for a year, before dying of a recurrence of cholangiocarcinoma. Although longer follow-up periods and more case studies will be required to establish the safety. . . © 1981, Massachusetts Medical Society. All rights reserved.