Formulation and Evaluation of Loperamide HCl fast dissolving tablets using cross treated Xanthan Gum

Various fast dissolving drug formulations have been recently introduced into the market. This work proposes the design of novel oral fast dissolving tablets (FDT’s) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. The excipients were used for this study was based on the compatibility studies. Optimized orally oral fast dissolving tablets were prepared by the direct compression method from cross xanthan gum development to the industrial scale technique. The results show that loperamide HCl FDT’s  offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured FDT’s complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in-vitro dissolution profile. Drug compatibility with excipients was checked by FTIR studies.