Noise-induced hearing loss in G6PD transgenic mouse

Oxidative stress is a major triggering factor for noise-induced hearing loss. Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-limiting step in the pentose-phosphate pathway, and is a key molecule in the cellular antioxidant response. G6PD overexpression in the transgenic mouse delays the onset of age-related hearing loss. However, its antioxidant potential against noise has not been explored yet. In this work, it has been shown that G6PD overexpression transiently protects against hearing damage caused by noise exposure, through activation of the antioxidant response mediated by NRF2-NQO1 and SOD