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Global Gene Expression Characterization of Circulating Tumor Cells in Metastasic Castration-Resistant Prostate Cancer Patients

Authors :
Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
León Mateos, Luis
Abalo, Alicia
Casas, Helena
Anido, Urbano
Rapado González, Óscar
Vieito, María
Suárez Cunqueiro, María Mercedes
Gómez Tato, Antonio
Abal Posada, Miguel
López López, Rafael
Muinelo Romay, Laura
Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
León Mateos, Luis
Abalo, Alicia
Casas, Helena
Anido, Urbano
Rapado González, Óscar
Vieito, María
Suárez Cunqueiro, María Mercedes
Gómez Tato, Antonio
Abal Posada, Miguel
López López, Rafael
Muinelo Romay, Laura
Publication Year :
2020

Abstract

Background: Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tumors, including PC, often do not have recent tumor tissue available for analysis. The biomarker characterization in CTCs could provide insights into the current state of the disease and an overall picture of the intra-tumor heterogeneity. Methods: in the present study, we applied a global gene expression characterization of the CTC population from mCRPC (n = 9), with the goal to better understand the biology of these cells and identify the relevant molecules favoring this tumor progression. Results: This analysis allowed the identification of 50 genes specifically expressed in CTCs from patients. Six of these markers (HOXB13, QKI, MAOA, MOSPD1, SDK1, and FGD4), were validated in a cohort of 28 mCRPC, showing clinical interest for the management of these patients. Of note, the activity of this CTC signature was related to the regulation of MYC, a gene strongly implicated in the biology of mCRPC. Conclusions: Overall, our results represent new evidence on the great value of CTCs as a non-invasive biopsy to characterize PC

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1400979042
Document Type :
Electronic Resource