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Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study.

Authors :
Weir, Ashley
Weir, Ashley
Kang, Eun-Young
Meagher, Nicola S
Nelson, Gregg S
Ghatage, Prafull
Lee, Cheng-Han
Riggan, Marjorie J
Gentry-Maharaj, Aleksandra
Ryan, Andy
Singh, Naveena
Widschwendter, Martin
Alsop, Jennifer
Anglesio, Michael S
Beckmann, Matthias W
Berger, Jessica
Bisinotto, Christiani
Boros, Jessica
Brand, Alison H
Brenton, James D
Brooks-Wilson, Angela
Carney, Michael E
Cunningham, Julie M
Cushing-Haugen, Kara L
Cybulski, Cezary
Elishaev, Esther
Erber, Ramona
Fereday, Sian
Fischer, Anna
Paz-Ares, Luis
Gayarre, Javier
Gilks, Blake C
Grube, Marcel
Harnett, Paul R
Harris, Holly R
Hartmann, Arndt
Hein, Alexander
Hendley, Joy
Hernandez, Brenda Y
Heublein, Sabine
Huang, Yajue
Huzarski, Tomasz
Jakubowska, Anna
Jimenez-Linan, Mercedes
Kennedy, Catherine J
Kommoss, Felix KF
Koziak, Jennifer M
Kraemer, Bernhard
Le, Nhu D
Lesnock, Jaime
Lester, Jenny
Lubiński, Jan
Menkiszak, Janusz
Ney, Britta
Olawaiye, Alexander
Orsulic, Sandra
Osorio, Ana
Robles-Díaz, Luis
Ruebner, Matthias
Shah, Mitul
Sharma, Raghwa
Shvetsov, Yurii B
Steed, Helen
Talhouk, Aline
Taylor, Sarah E
Traficante, Nadia
Vierkant, Robert A
Wang, Chen
Wilkens, Lynne R
Winham, Stacey J
Benitez, Javier
Berchuck, Andrew
Bowtell, David D
Candido Dos Reis, Francisco J
Cook, Linda S
DeFazio, Anna
AOCs group
Doherty, Jennifer A
Fasching, Peter A
García, María J
Goode, Ellen L
Goodman, Marc T
Gronwald, Jacek
Huntsman, David G
Karlan, Beth Y
Kommoss, Stefan
Modugno, Francesmary
Schildkraut, Joellen M
Sinn, Hans-Peter
Staebler, Annette
Kelemen, Linda E
Ford, Caroline E
Menon, Usha
Pharoah, Paul DP
Köbel, Martin
Ramus, Susan J
Weir, Ashley
Weir, Ashley
Kang, Eun-Young
Meagher, Nicola S
Nelson, Gregg S
Ghatage, Prafull
Lee, Cheng-Han
Riggan, Marjorie J
Gentry-Maharaj, Aleksandra
Ryan, Andy
Singh, Naveena
Widschwendter, Martin
Alsop, Jennifer
Anglesio, Michael S
Beckmann, Matthias W
Berger, Jessica
Bisinotto, Christiani
Boros, Jessica
Brand, Alison H
Brenton, James D
Brooks-Wilson, Angela
Carney, Michael E
Cunningham, Julie M
Cushing-Haugen, Kara L
Cybulski, Cezary
Elishaev, Esther
Erber, Ramona
Fereday, Sian
Fischer, Anna
Paz-Ares, Luis
Gayarre, Javier
Gilks, Blake C
Grube, Marcel
Harnett, Paul R
Harris, Holly R
Hartmann, Arndt
Hein, Alexander
Hendley, Joy
Hernandez, Brenda Y
Heublein, Sabine
Huang, Yajue
Huzarski, Tomasz
Jakubowska, Anna
Jimenez-Linan, Mercedes
Kennedy, Catherine J
Kommoss, Felix KF
Koziak, Jennifer M
Kraemer, Bernhard
Le, Nhu D
Lesnock, Jaime
Lester, Jenny
Lubiński, Jan
Menkiszak, Janusz
Ney, Britta
Olawaiye, Alexander
Orsulic, Sandra
Osorio, Ana
Robles-Díaz, Luis
Ruebner, Matthias
Shah, Mitul
Sharma, Raghwa
Shvetsov, Yurii B
Steed, Helen
Talhouk, Aline
Taylor, Sarah E
Traficante, Nadia
Vierkant, Robert A
Wang, Chen
Wilkens, Lynne R
Winham, Stacey J
Benitez, Javier
Berchuck, Andrew
Bowtell, David D
Candido Dos Reis, Francisco J
Cook, Linda S
DeFazio, Anna
AOCs group
Doherty, Jennifer A
Fasching, Peter A
García, María J
Goode, Ellen L
Goodman, Marc T
Gronwald, Jacek
Huntsman, David G
Karlan, Beth Y
Kommoss, Stefan
Modugno, Francesmary
Schildkraut, Joellen M
Sinn, Hans-Peter
Staebler, Annette
Kelemen, Linda E
Ford, Caroline E
Menon, Usha
Pharoah, Paul DP
Köbel, Martin
Ramus, Susan J
Source :
British journal of cancer; vol 128, iss 1, 137-147; 0007-0920
Publication Year :
2023

Abstract

BackgroundRecently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed to translate prognostic mRNA markers into protein expression assays by immunohistochemistry and validate their survival association in HGSC.MethodsTwo prognostic genes, FOXJ1 and GMNN, were selected based on high-quality antibodies, correlation with protein expression and variation in immunohistochemical scores in a preliminary cohort (n = 134 and n = 80, respectively). Six thousand four hundred and thirty-four (FOXJ1) and 5470 (GMNN) formalin-fixed, paraffin-embedded ovarian neoplasms (4634 and 4185 HGSC, respectively) represented on tissue microarrays from the Ovarian Tumor Tissue Analysis consortium underwent immunohistochemical staining and scoring, then univariate and multivariate survival analysis.ResultsConsistent with mRNA, FOXJ1 protein expression exhibited a linear, increasing association with improved overall survival in HGSC patients. Women with >50% expression had the most favourable outcomes (HR = 0.78, 95% CI 0.67-0.91, p < 0.0001). GMNN protein expression was not significantly associated with overall HSGC patient survival. However, HGSCs with >35% GMNN expression showed a trend for better outcomes, though this was not significant.ConclusionWe provide foundational evidence for the prognostic value of FOXJ1 in HGSC, validating the prior mRNA-based prognostic association by immunohistochemistry.

Details

Database :
OAIster
Journal :
British journal of cancer; vol 128, iss 1, 137-147; 0007-0920
Notes :
application/pdf, British journal of cancer vol 128, iss 1, 137-147 0007-0920
Publication Type :
Electronic Resource
Accession number :
edsoai.on1393988868
Document Type :
Electronic Resource