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Insula-Retrosplenial Cortex Overconnectivity Increases Internalizing via Reduced Insight in Autism.
- Source :
- Biological psychiatry; vol 84, iss 4, 287-294; 0006-3223
- Publication Year :
- 2018
-
Abstract
- BackgroundInternalizing symptoms like anxiety and depression are common and impairing in autism spectrum disorder (ASD). Here, we test the hypothesis that aberrant functional connectivity among three brain networks (salience network [SN], default mode network [DMN], and frontoparietal network [FPN]) plays a role in the pathophysiology of internalizing in ASD.MethodsWe examined the association between resting-state functional connectivity and internalizing in 102 adolescents and young adults with ASD (n = 49) or typical development (n = 53). Seed-to-target functional connectivity was contrasted between adolescents and young adults with ASD and typically developing subjects using a recent parcellation of the human cerebral cortex, and connections that were aberrant in ASD were analyzed dimensionally as a function of parent-reported internalizing symptoms.ResultsThree connections demonstrated robust overconnectivity in ASD: 1) the anterior insula to the retrosplenial cortex (i.e., SN-DMN), 2) the anterior insula to the frontal pole (i.e., SN-FPN), and 3) the dorsolateral prefrontal cortex to the retrosplenial cortex (i.e., FPN-DMN). These differences remained significant after controlling for age, and no age-related effects survived correction. The SN-DMN connection was associated with greater internalizing in ASD, mediated by a bigger difference between self- and parent-reported internalizing. Control analyses found that the other two connections were not associated with internalizing, and SN-DMN connectivity was not associated with a well-matched control measure (externalizing symptoms).ConclusionsThe present findings provide novel evidence for a specific link between SN-DMN overconnectivity and internalizing in ASD. Further, the mediation results suggest that intact anterior insula-retrosplenial connectivity may play a role in an individual's generating insight into his or her own psychopathology.
Details
- Database :
- OAIster
- Journal :
- Biological psychiatry; vol 84, iss 4, 287-294; 0006-3223
- Notes :
- Hogeveen, Jeremy, Krug, Marie K, Elliott, Matthew V, Solomon, Marjorie
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1391611225
- Document Type :
- Electronic Resource