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A sleep apnoea questionnaire predicts organ damage in hypertensive patients

Authors :
Bisogni, V
Pengo, M
Maiolino, G
Cesari, M
Lerco, S
Rossitto, G
Concistrè, A
Petramala, L
Letizia, C
Seccia, T
Rossi, G
Bisogni V
Pengo M
Maiolino G
Cesari M
Lerco S
Rossitto G
Concistrè A
Petramala L
Letizia C
Seccia TM
Rossi GP.
Bisogni, V
Pengo, M
Maiolino, G
Cesari, M
Lerco, S
Rossitto, G
Concistrè, A
Petramala, L
Letizia, C
Seccia, T
Rossi, G
Bisogni V
Pengo M
Maiolino G
Cesari M
Lerco S
Rossitto G
Concistrè A
Petramala L
Letizia C
Seccia TM
Rossi GP.
Publication Year :
2019

Abstract

Background: Arterial hypertension is associated with obstructive sleep apnoea, poor quality and duration of sleep, which might contribute to hypertension-mediated organ damage. Methods: We investigated the presence of insomnia, restless legs syndrome, and obstructive sleep apnoea using validated questionnaires (Insomnia Severity Index, Restless Legs Syndrome Rating Scale, and STOP-Bang), and their relationship with hypertension-mediated organ damage, in hypertensive patients. Results: In 159 consecutive consenting hypertensive patients [age 47(11) years, median and (interquartile range), body mass index 25.5(5.9) kg/m 2 , office systolic and diastolic blood pressure 144(23)/92(12) mmHg], the STOP-Bang, but not the other scores, predicted cardiac remodelling: compared to patients with a STOP-Bang score < 3, those at high risk of obstructive sleep apnoea showed higher left ventricular mass index [49.8(11.9) vs. 43.3(11.9) g/m 2.7 , p < 0.0001], left atrium volume [25.7(2.5) vs. 25.0(2.8) ml/m 2 , p = 0.003], and aortic root diameter [33.6(3.0) vs. 33.0(3.7) mm, p < 0.0001]. They did not differ for microalbuminuria and estimated glomerular filtration rate. At multivariate analysis, after adjustment for office systolic blood pressure values, the STOP-Bang score remained a predictor of left ventricular mass index; while the Insomnia Severity Index and restless legs syndrome risk score had no predictive value. However, a significant interaction between STOP-Bang and Restless Legs Syndrome Rating Scale scores in determining left ventricular remodelling was found. Conclusions: In consecutive hypertensive stage I patients the STOP-Bang questionnaire allowed identification of a high-risk cohort featuring a more prominent cardiac damage. Hence, this inexpensive tool can be useful for risk stratification purposes in municipalities with limited access to health care resources.

Details

Database :
OAIster
Notes :
STAMPA, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1383768617
Document Type :
Electronic Resource