The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice

Authors :: De Munck, Toon J.
Xu, Pan
Vanderfeesten, Brechtje L. J.
Elizalde, Montserrat
Masclee, Ad A. M.
Nevens, Frederik
Cassiman, David
Schaap, Frank G.
Jonkers, Daisy M. A. E.
Verbeek, Jef
De Munck, Toon J.
Xu, Pan
Vanderfeesten, Brechtje L. J.
Elizalde, Montserrat
Masclee, Ad A. M.
Nevens, Frederik
Cassiman, David
Schaap, Frank G.
Jonkers, Daisy M. A. E.
Verbeek, Jef
Source :: Hormone and Metabolic Research vol.52 (2020) nr.12 p.869-876 [ISSN 0018-5043]
Publication Year :: 2020
Abstract: Brown adipose tissue (BAT) might be a beneficial mediator in the development and treatment of nonalcoholic steatohepatitis (NASH). We aim to evaluate the gene expression of BAT activity-related genes during the development and the dietary and surgical treatment of NASH. BAT was collected from male C57BL/6J mice that received a high fat-high sucrose diet (HF-HSD) or a normal chow diet (NCD) for 4 and 20 weeks (n=8-9 per dietary group and timepoint) and from mice that underwent dietary intervention (return to NCD) (n=8), roux-en-y gastric bypass (RYGB) (n=6), or sham procedure (n=6) after 12 weeks HF-HSD. Expression of BAT genes involved in lipid metabolism (Cd36 and Cpt1b; p

Database :: OAIster
Journal :: Hormone and Metabolic Research vol.52 (2020) nr.12 p.869-876 [ISSN 0018-5043]
Notes :: DOI: 10.1055/a-1301-2378, English
Publication Type :: Electronic Resource
Accession number :: edsoai.on1383763509
Document Type :: Electronic Resource

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