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Hand eczema and temporal variation of Staphylococcus aureus clonal complexes:A prospective observational study
- Source :
- Nørreslet , L B , Edslev , S M , Clausen , M L , Flachs , E M , Ebbehøj , N E , Andersen , P S & Agner , T 2022 , ' Hand eczema and temporal variation of Staphylococcus aureus clonal complexes : A prospective observational study ' , Journal of the American Academy of Dermatology , vol. 87 , no. 5 , pp. 1006-1013 .
- Publication Year :
- 2022
-
Abstract
- Background: Hand eczema (HE) is frequently associated with Staphylococcus aureus; however, its role in the pathogenesis of HE is poorly understood. Objective: To investigate the temporal variation in S aureus subtypes, ie, clonal complex (CC) types, on the hands and relate it to S aureus colonization in the nose and severity in a cohort of HE patients. Methods: S aureus from the hands and nose of 50 adult HE patients and 50 controls was prospectively identified at 5 visits over 3 weeks. Results: S aureus was identified on the hands of 23 (46%) patients at 2 or more visits and on the hands of 1 control once. Of the HE patients with S aureus colonization, 78% had the same S aureus CC type over time. Twenty-one patients had the same S aureus CC type on the hands and in the nose. Persistent colonization was strongly related to an increased disease severity. Limitations: A relatively small S aureus culture-positive population. Conclusion: The temporal stability of S aureus CC type and high occurrence of the identical subtypes on the hands and in the nose imply that S aureus colonization in patients with HE is of a more permanent nature. Taken together with the finding that persistent colonization and HE severity are clearly related, our results indicate that S aureus may contribute to the perpetuating course of HE.
Details
- Database :
- OAIster
- Journal :
- Nørreslet , L B , Edslev , S M , Clausen , M L , Flachs , E M , Ebbehøj , N E , Andersen , P S & Agner , T 2022 , ' Hand eczema and temporal variation of Staphylococcus aureus clonal complexes : A prospective observational study ' , Journal of the American Academy of Dermatology , vol. 87 , no. 5 , pp. 1006-1013 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1382512143
- Document Type :
- Electronic Resource