Clinical Data May Be Used to Predict the Development of Heterotopic Ossification in Combat-Related Extremity Trauma at Hospital Admission

*SC2i is a consortium of Walter Reed National Military Medical Center, Naval Medical Research Center, Duke Medicine, Emory University School of Medicine, and Henry M. Jackson Foundation for the Advancement of Military Medicine, and Decision Q The contents of this presentation are the sole responsibility of the author(s) and do not necessarily reflect the views, opinions or policies of Uniformed Services University of the Health Sciences (USUHS), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., the Department of Defense (DoD) or the Departments of the Army, Navy, or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. Government. Heterotopic ossification (HO), an ectopic bone formation (Figure 1), is a common treatment complication associated with combat-related extremity trauma accompanied by hyper- inflammatory systemic response, increased wound bioburden and extremity amputations. Surgical excision is indicated in symptomatic cases, which are frequent. After development, HO becomes a substantial challenge to recovery, functional mobility and return to duty. Estimating the risk of development of HO at hospital admission may help identify patients who should benefit most of early methods of prophylaxis such as the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Here we investigated if the development of HO in patients with combat-related extremity trauma could be predicted at hospital admission based on clinical data. INTRODUCTION METHODS INTRODUCTION Figure 1. Heterotopic ossification in patient with femoral amputation before and after focal excision of symptomatic area. In Clin Orthop Relat Res (2015) 473:2814–2824 RESULTS CONCLUSION Clinical Data May Be Used to Predict the Development of Heterotopic Ossification in Combat-Related Extremity Trauma at Hospital Admission Felipe A. Lisboa, MD1,2,6,7, Benjamin K. Potter, MD1,2,6, Matthew J. Bradley, MD1,2,6, Henry Robertson
RITM0028154
Heterotopic ossification (HO), an ectopic bone formation (Figure 1), is a common treatment complication associated with combatrelated extremity trauma accompanied by hyper- inflammatory systemic response, increased wound bioburden and extremity amputations. Surgical excision is indicated in symptomatic cases, which are frequent. After development, HO becomes a substantial challenge to recovery, functional mobility and return to duty. Estimating the risk of development of HO at hospital admission may help identify patients who should benefit most of early methods of prophylaxis such as the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Here we investigated if the development of HO in patients with combat-related extremity trauma could be predicted at hospital admission based on clinical data.