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Fabrication and Physical Evaluation of Gelatin-Coated Carbonate Apatite Foam

Authors :
Hara, Kanae
Fujisawa, Kenji
Nagai, Hirokazu
Takamaru, Natsumi
Ohe, Go
Tsuru, Kanji
Ishikawa, Kunio
Miyamoto, Youji
Hara, Kanae
Fujisawa, Kenji
Nagai, Hirokazu
Takamaru, Natsumi
Ohe, Go
Tsuru, Kanji
Ishikawa, Kunio
Miyamoto, Youji
Publication Year :
2016

Abstract

Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin; however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.

Details

Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1378506409
Document Type :
Electronic Resource