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Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries
- Source :
- Logroscino , G , Piccininni , M , Graff , C , Hardiman , O , Ludolph , A C , Moreno , F , Otto , M , Remes , A M , Rowe , J B , Seelaar , H , Solje , E , Stefanova , E , Traykov , L , Jelic , V , Rydell , M T , Pender , N , Anderl-Straub , S , Barandiaran , M , Gabilondo , A , Krüger , J , Murley , A G , Rittman , T , Van Der Ende , E L , Van Swieten , J C , Hartikainen , P , Stojmenović , G M , Mehrabian , S , Benussi , L , Alberici , A , Dell'abate , M T , Zecca , C & Borroni , B 2023 , ' Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries ' , JAMA Neurology , vol. 80 , no. 3 , pp. 279-286 .
- Publication Year :
- 2023
-
Abstract
- Importance: Diagnostic incidence data for syndromes associated with frontotemporal lobar degeneration (FTLD) in multinational studies are urgent in light of upcoming therapeutic approaches. Objective: To assess the incidence of FTLD across Europe. Design, Setting, and Participants: The Frontotemporal Dementia Incidence European Research Study (FRONTIERS) was a retrospective cohort study conducted from June 1, 2018, to May 31, 2019, using a population-based registry from 13 tertiary FTLD research clinics from the UK, the Netherlands, Finland, Sweden, Spain, Bulgaria, Serbia, Germany, and Italy and including all new FTLD-associated cases during the study period, with a combined catchment population of 11023643 person-years. Included patients fulfilled criteria for the behavioral variant of frontotemporal dementia (BVFTD), the nonfluent variant or semantic variant of primary progressive aphasia (PPA), unspecified PPA, progressive supranuclear palsy, corticobasal syndrome, or frontotemporal dementia with amyotrophic lateral sclerosis (FTD-ALS). Data were analyzed from July 19 to December 7, 2021. Main Outcomes and Measures: Random-intercept Poisson models were used to obtain estimates of the European FTLD incidence rate accounting for geographic heterogeneity. Results: Based on 267 identified cases (mean [SD] patient age, 66.70 [9.02] years; 156 males [58.43%]), the estimated annual incidence rate for FTLD in Europe was 2.36 cases per 100000 person-years (95% CI, 1.59-3.51 cases per 100000 person-years). There was a progressive increase in FTLD incidence across age, reaching its peak at the age of 71 years, with 13.09 cases per 100 000 person-years (95% CI, 8.46-18.93 cases per 100 000 person-years) among men and 7.88 cases per 100 000 person-years (95% CI, 5.39-11.60 cases per 100 000 person-years) among women. Overall, the incidence was higher among men (2.84 cases per 100000 person-years; 95% CI, 1.88-4.27 cases per 100000 person-years) than among women (1.91 case
Details
- Database :
- OAIster
- Journal :
- Logroscino , G , Piccininni , M , Graff , C , Hardiman , O , Ludolph , A C , Moreno , F , Otto , M , Remes , A M , Rowe , J B , Seelaar , H , Solje , E , Stefanova , E , Traykov , L , Jelic , V , Rydell , M T , Pender , N , Anderl-Straub , S , Barandiaran , M , Gabilondo , A , Krüger , J , Murley , A G , Rittman , T , Van Der Ende , E L , Van Swieten , J C , Hartikainen , P , Stojmenović , G M , Mehrabian , S , Benussi , L , Alberici , A , Dell'abate , M T , Zecca , C & Borroni , B 2023 , ' Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries ' , JAMA Neurology , vol. 80 , no. 3 , pp. 279-286 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1376785613
- Document Type :
- Electronic Resource